0001326110-22-000011 | 10-K | XBRL Viewer

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Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 181,101	$ 34,915
Marketable securities	136,015	61,146
Due from related parties	1,333	2,003
Prepaid expenses and other current assets (including amounts with related parties)	15,898	13,649
Total current assets	334,347	111,713
Marketable securities, noncurrent	822	950
Property, plant and equipment, net	82,863	72,541
Non-marketable equity investment	0	7,800
Intangible asset, net	1,420	1,463
Convertible note receivable	6,379	6,129
Operating lease right-of-use assets, net (including amounts with related parties)	36,304	18,138
Investment and other assets (including amounts with related parties)	6,775	2,598
Total assets	468,910	221,381
Current liabilities:
Accounts payable	11,418	11,510
Accrued expenses and other liabilities	51,387	36,771
Related-party notes payable	299,236	0
Due to related parties	3,943	14,838
Operating lease liabilities (including amounts with related parties)	3,011	5,015
Total current liabilities	368,995	68,134
Related-party notes payable, less current portion	306,349	254,353
Operating lease liabilities, less current portion (including amounts with related parties)	37,068	16,179
Deferred tax liability	162	170
Other liabilities	249	1,035
Total liabilities	712,823	339,871
Commitments and contingencies (Note 7)
Stockholders’ deficit:
Common stock, $0.0001 par value; 500,000,000 shares authorized; 397,830,044 and 382,243,142 shares issued and outstanding as of December 31, 2021 and 2020, respectively; excluding treasury stock, 163,800 shares outstanding as of December 31, 2021 and 2020, respectively	40	38
Additional paid-in capital	1,719,704	1,495,163
Accumulated deficit	(1,961,921)	(1,615,131)
Accumulated other comprehensive income	4	122
Total ImmunityBio stockholders’ deficit	(242,173)	(119,808)
Noncontrolling interests	(1,740)	1,318
Total stockholders’ deficit	(243,913)	(118,490)
Total liabilities and stockholders’ deficit	$ 468,910	$ 221,381

Consolidated Balance Sheets (Parenthetical) - $ / shares	Dec. 31, 2021	Mar. 09, 2021	Dec. 31, 2020
Statement of Financial Position [Abstract]
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	500,000,000		500,000,000
Common stock, shares issued (in shares)	397,830,044		382,243,142
Common stock, shares outstanding (in shares)	397,830,044		382,243,142
Treasury stock, shares outstanding (in shares)	163,800		163,800

Consolidated Statements of Operations - USD ($)	3 Months Ended	12 Months Ended
Consolidated Statements of Operations - USD ($)	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Statement [Abstract]
Revenue	$ 139,000	$ 934,000	$ 605,000	$ 2,202,000
Operating expenses:
Research and development (including amounts with related parties)	41,128,000	195,958,000	139,507,000	111,997,000
Selling, general and administrative (including amounts with related parties)	45,275,000	135,256,000	71,318,000	46,456,000
Impairment of intangible assets		0	10,660,000	0
Total operating expenses		331,214,000	221,485,000	158,453,000
Loss from operations	(86,264,000)	(330,280,000)	(220,880,000)	(156,251,000)
Other expense, net:
Interest and investment (loss) income, net		(4,100,000)	2,435,000	2,442,000
Interest expense (including amounts with related parties)		(14,849,000)	(9,074,000)	(5,920,000)
Loss on equity method investment		(803,000)	0	0
Other income (expense), net (including amounts with related parties)		193,000	1,486,000	(534,000)
Total other expense, net	5,789,000	(19,559,000)	(5,153,000)	(4,012,000)
Loss before income taxes and noncontrolling interests		(349,839,000)	(226,033,000)	(160,263,000)
Income tax (expense) benefit	(6,000)	(9,000)	1,846,000	105,000
Net loss	$ (80,481,000)	(349,848,000)	(224,187,000)	(160,158,000)
Net loss attributable to noncontrolling interests, net of tax		(3,058,000)	(2,336,000)	(2,381,000)
Net loss attributable to ImmunityBio common stockholders		$ (346,790,000)	$ (221,851,000)	$ (157,777,000)
Net loss per ImmunityBio common share - basic (in dollars per share)		$ (0.89)	$ (0.59)	$ (0.43)
Net loss per ImmunityBio common share - diluted (in dollars per share)		$ (0.89)	$ (0.59)	$ (0.43)
Weighted-average number of common shares used in computing net loss per share – basic (in shares)		389,234,156	377,067,527	366,324,859
Weighted-average number of common shares used in computing net loss per share – diluted (in shares)		389,234,156	377,067,527	366,324,859

Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Statement of Comprehensive Income [Abstract]
Net loss	$ (349,848)	$ (224,187)	$ (160,158)
Other comprehensive (loss) income, net of income taxes:
Net unrealized (losses) gains on available-for-sale securities	(13)	140	158
Reclassification of net realized losses on available-for-sale securities included in net loss	0	9	4
Foreign currency translation adjustments	(105)	60	(35)
Total other comprehensive (loss) income	(118)	209	127
Comprehensive loss	(349,966)	(223,978)	(160,031)
Less: Comprehensive loss attributable to noncontrolling interests	(3,058)	(2,336)	(2,381)
Comprehensive loss attributable to ImmunityBio common stockholders	$ (346,908)	$ (221,642)	$ (157,650)

Consolidated Statements of Stockholders' Deficit - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment	Accumulated Other Comprehensive (Loss) Income	Total ImmunityBio Stockholders’ Equity (Deficit)	Total ImmunityBio Stockholders’ Equity (Deficit) Cumulative Effect, Period of Adoption, Adjustment	Noncontrolling Interests
Beginning balance (in shares) at Dec. 31, 2018			348,677,955
Beginning balance at Dec. 31, 2018	$ 81,943		$ 35	$ 1,326,760	$ (1,232,320)		$ (214)	$ 94,261		$ (12,318)
Increase (Decrease) in Statements of Stockholders’ Deficit [Roll Forward]
Issuance of common stock, net (in shares)			2,047,500
Issuance of common stock, net	30,000		$ 0	30,000				30,000
Stock-based compensation expense	3,421			3,421				3,421
Exercise of warrants (in shares)			19,664,050
Exercise of warrants	41,864		$ 2	41,862				41,864
Exercise of stock options, (in shares)			1,995,120
Exercise of stock options	4,086			4,086				4,086
Vesting of restricted stock units (RSUs) (in shares)			395,051
Net share settlement for RSUs vesting and warrant exercises (in shares)			(124,345)
Net share settlement for RSUs vesting and warrant exercises	(127)			(127)				(127)
Repurchase of common stock (in shares)			(678,336)
Repurchase of common stock	(2,501)				(2,501)			(2,501)
Deconsolidation of Precision Biologics	18,353									18,353
Other comprehensive income (loss), net of tax	127						127	127
Net loss	(160,158)				(157,777)			(157,777)		(2,381)
Ending balance (in shares) at Dec. 31, 2019			371,976,995
Ending balance at Dec. 31, 2019	16,326	$ (682)	$ 37	1,406,002	(1,393,280)	$ (682)	(87)	12,672	$ (682)	3,654
Increase (Decrease) in Statements of Stockholders’ Deficit [Roll Forward]
Issuance of common stock, net (in shares)			8,521,500
Issuance of common stock, net	86,302		$ 1	86,301				86,302
Stock-based compensation expense	2,187			2,187				2,187
Exercise of stock options, (in shares)			1,272,273
Exercise of stock options	1,176			1,176				1,176
Vesting of restricted stock units (RSUs) (in shares)			648,336
Net share settlement for RSUs vesting and warrant exercises (in shares)			(175,962)
Net share settlement for RSUs vesting and warrant exercises	(503)			(503)				(503)
Other comprehensive income (loss), net of tax	209						209	209
Net loss	$ (224,187)				(221,851)			(221,851)		(2,336)
Ending balance (in shares) at Dec. 31, 2020	382,243,142		382,243,142
Ending balance at Dec. 31, 2020	$ (118,490)		$ 38	1,495,163	(1,615,131)		122	(119,808)		1,318
Increase (Decrease) in Statements of Stockholders’ Deficit [Roll Forward]
Issuance of common stock, net (in shares)			13,295,817
Issuance of common stock, net	164,530		$ 2	164,528				164,530
Stock-based compensation expense	$ 57,181			57,181				57,181
Exercise of stock options, (in shares)	1,817,300		1,695,638
Exercise of stock options	$ 5,461			5,461				5,461
Vesting of restricted stock units (RSUs) (in shares)			873,058
Net share settlement for RSUs vesting and warrant exercises (in shares)			(277,611)
Net share settlement for RSUs vesting and warrant exercises	(4,064)			(4,064)				(4,064)
Sales of assets to an entity under common control	1,435			1,435				1,435
Other comprehensive income (loss), net of tax	(118)						(118)	(118)
Net loss	$ (349,848)				(346,790)			(346,790)		(3,058)
Ending balance (in shares) at Dec. 31, 2021	397,830,044		397,830,044
Ending balance at Dec. 31, 2021	$ (243,913)		$ 40	$ 1,719,704	$ (1,961,921)		$ 4	$ (242,173)		$ (1,740)

Consolidated Statements of Stockholders' Deficit Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2018
Accounting Standards Update [Extensible Enumeration]		us-gaap:AccountingStandardsUpdate201602Member
At-the-Market
Stock issuance costs	$ 4,674

- Definition

Indicates amendment to accounting standards.

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+ Details

Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
Consolidated Statements of Cash Flows - USD ($)	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Operating activities:
Net loss	$ (349,848,000)	$ (224,187,000)	$ (160,158,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	57,181,000	2,187,000	3,421,000
Depreciation and amortization	14,238,000	12,739,000	14,042,000
Non-cash interest items, net (including amounts with related parties)	12,479,000	8,531,000	(704,000)
Non-cash lease expense related to operating lease right-of-use assets	4,884,000	5,155,000	4,131,000
Unrealized losses (gains) on equity securities	4,615,000	(2,876,000)	320,000
Unrealized loss on non-marketable equity investment	0	1,405,000	0
Loss on equity method investment	803,000	0	0
Impairment of intangible assets	0	10,660,000	0
Impairment of fixed assets	0	0	1,593,000
Deferred tax	(8,000)	(2,938,000)	(8,000)
Other	349,000	1,240,000	890,000
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(2,249,000)	4,208,000	5,837,000
Investment and other assets	(3,977,000)	(684,000)	(4,009,000)
Accounts payable	(3,717,000)	2,570,000	1,188,000
Accrued expenses and other liabilities	5,182,000	12,495,000	(11,796,000)
Related parties	(10,187,000)	3,378,000	(2,380,000)
Operating lease liabilities	(4,164,000)	(5,607,000)	(4,476,000)
Net cash used in operating activities	(274,419,000)	(171,724,000)	(152,109,000)
Investing activities:
Purchases of property, plant and equipment	(33,563,000)	(1,669,000)	(4,287,000)
Proceeds from sales of property, plant and equipment	20,498,000	0	200,000
Purchases of marketable debt securities, available-for-sale	(141,750,000)	(91,765,000)	(87,189,000)
Maturities of marketable debt securities, available for sale	56,166,000	65,350,000	109,730,000
Proceeds from sales of marketable debt and equity securities	13,763,000	8,272,000	2,601,000
Payment to Precision Biologics to facilitate deconsolidation	0	0	(2,500,000)
Purchase of non-marketable equity investment	0	0	(3,000)
Net cash (used in) provided by investing activities	(84,886,000)	(19,812,000)	18,552,000
Financing activities:
Proceeds from equity offering, net of issuance costs paid	164,530,000	86,302,000	30,000,000
Proceeds from issuance of related-party promissory notes, net of issuance costs paid	338,500,000	63,700,000	47,670,000
Proceeds from exercises of stock options	5,461,000	1,176,000	4,086,000
Sale of assets to an entity under common control	1,435,000	0	0
Net share settlement for RSUs vesting and warrant exercise	(4,064,000)	(503,000)	(127,000)
Payment for contingent consideration	(419,000)	0	0
Proceeds from exercises of warrants	0	0	35,151,000
Repurchase of common stock	0	0	(2,501,000)
Net cash provided by financing activities	505,443,000	150,675,000	114,279,000
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	48,000	(25,000)	(21,000)
Net change in cash, cash equivalents, and restricted cash	146,186,000	(40,886,000)	(19,299,000)
Cash, cash equivalents, and restricted cash, beginning of year	35,094,000	75,980,000	95,279,000
Cash, cash equivalents, and restricted cash, end of year	181,280,000	35,094,000	75,980,000
Reconciliation of cash, cash equivalents, and restricted cash, end of year:
Cash and cash equivalents	181,101,000	34,915,000	75,801,000
Restricted cash (Note 2)	179,000	179,000	179,000
Supplemental disclosure of cash flow information:
Interest	2,106,000	40,000	19,000
Income taxes	9,000	8,000	3,000
Supplemental disclosure of non-cash activities:
Right-of-use assets obtained in exchange for operating lease liabilities	23,069,000	2,394,000	1,968,000
Property and equipment purchases included in accounts payable, accrued expenses and due to related parties	11,654,000	220,000	662,000
Unrealized (losses) gains on marketable debt securities	(13,000)	(17,000)	258,000
Cashless exercise of stock options	1,035,000	1,233,000	29,000
Accrued investment in joint venture	1,000,000	0	0
Issuance of equity for warrant exercise via reduction of related-party promissory notes	0	0	6,713,000
Conversion of convertible notes and accrued interest into non-marketable equity investment	$ 0	$ 0	$ 751,000

Description of Business

12 Months Ended

Dec. 31, 2021

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Description of Business

In these notes to the consolidated financial statements, the terms “ImmunityBio,” “the company,” “the combined company,” “we,” “us,” and “our” refer to ImmunityBio and subsidiaries.

Our Business

ImmunityBio, Inc. is a clinical-stage biotechnology company developing next-generation therapies and vaccines that complement, harness, and amplify the immune system to defeat cancers and infectious diseases. We strive to be a vertically-integrated immunotherapy company designing and manufacturing our products so they are more effective, accessible, more conveniently stored, and more easily administered to patients.

Our broad immunotherapy and cell therapy platforms are designed to attack cancer and infectious pathogens by activating both the innate immune system—natural killer (NK) cells, dendritic cells, and macrophages—and the adaptive immune system—B cells and T cells—in an orchestrated manner. The goal of this potentially best-in-class approach is to generate immunogenic cell death thereby eliminating rogue cells from the body whether they are cancerous or virally infected and to ultimately establish an “immunological memory” that confers long-term benefit for the patient.

Although such designations may not lead to a faster development process or regulatory review and may not increase the likelihood that a product candidate will receive approval, Anktiva™, our novel antibody cytokine fusion protein, has received Breakthrough Therapy and Fast Track designations in combination with BCG from the U.S. Food and Drug Administration (FDA) for bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) carcinoma in situ (CIS). Based on the reported results of the trial, we have initiated discussions with the FDA to file a BLA for Anktiva (to be branded VesAnktiva™ for intravesical administration) plus BCG for BCG-unresponsive NMIBC CIS.

Our platforms, which include 17 first-in-human therapeutic agents, are being studied in 26 actively recruiting clinical trials—17 of which are in Phase 2 or 3 development—across 13 indications in liquid and solid tumors, including bladder, pancreatic and lung cancers. These are among the most frequent and lethal cancer types for which there are high failure rates for existing standards of care or, in some cases, no available effective treatment. In infectious disease, our pipeline currently targets such pathogens as the novel strain of the coronavirus (SARS-CoV-2) and human immunodeficiency virus (HIV).

We have established Good Manufacturing Process (GMP) manufacturing capacity at scale with cutting-edge cell manufacturing expertise and ready-to-scale facilities, as well as extensive and seasoned research and development (R&D), clinical trial, and regulatory operations, and development teams.

The Merger

Under the terms of the Merger Agreement, at the effective time of the Merger (the Effective Time), each share of NantCell common stock, par value $0.001 per share, issued and outstanding immediately prior to the Effective Time, subject to certain exceptions as set forth in the Merger Agreement, was converted automatically into a right to receive 0.8190 (the Exchange Ratio) newly issued shares of common stock, par value $0.0001 per share, of the company (Company Common Stock), with cash paid in lieu of any fractional shares. At the Effective Time, each share of the company’s common stock issued and outstanding immediately prior to the Effective Time, remained an issued and outstanding share of the combined company. At the Effective Time, each outstanding option, warrant or restricted stock unit to purchase NantCell common stock was converted using the Exchange Ratio into an option, warrant or restricted stock unit, respectively, on the same terms and conditions immediately prior to the Effective Time, to purchase shares of Company Common Stock.

Immediately following the Effective Time, the former stockholders of NantCell held approximately 71.5% of the outstanding shares of Company Common Stock and the stockholders of the company as of immediately prior to the Merger held approximately 28.5% of the outstanding shares of Company Common Stock. As a result of the Merger and immediately following the Effective Time, Dr. Patrick Soon-Shiong, our Executive Chairman and Global Chief Scientific and Medical Officer, and his affiliates beneficially owned, in the aggregate, approximately 81.8% of the outstanding shares of Company Common Stock. Following the consummation of the Merger, the symbol for shares of the company’s common stock was changed to “IBRX.”

We incurred costs totaling $23.3 million in connection with the Merger, consisting of financial advisory, legal and other professional fees, of which $13.0 million and $10.3 million were recorded for the years ended December 31, 2021 and 2020, respectively. Merger-related costs are reported in selling, general and administrative expense, on the consolidated statements of operations.

Accounting Treatment of the Merger

The Merger represents a business combination pursuant to Financial Accounting Standards Board (FASB) Accounting Standards Codification (ASC) Topic 805-50, Mergers, which is accounted for as a transaction between entities under common control as Dr. Soon-Shiong and his affiliates were the controlling stockholders of both the company and NantCell for all of the periods presented in this report. As a result, all of the assets and liabilities of NantCell were combined with ours at their historical carrying amounts on the closing date of the Merger. We have recast our prior period financial statements to reflect the conveyance of NantCell’s common shares as if the Merger had occurred as of the earliest date of the financial statements presented. All material intercompany accounts and transactions have been eliminated in consolidation.

The following tables provide the impact of the change in reporting entity on our unaudited condensed consolidated statements of operations for the three months ended March 31, 2021 and our consolidated statements of operations for the years ended December 31, 2020 and 2019, respectively (in thousands):


	Three Months Ended March 31, 2021
	(Unaudited)
	NantCell		NantKwest		Intercompany Eliminations		ImmunityBio, Inc.
Revenue	$	183	$	—	$	(44)	$	139
Operating expenses:
Research and development (including amounts with related parties)	21,509		19,725		(106)		41,128
Selling, general and administrative (including amounts with related parties)	24,382		20,903		(10)		45,275
Loss from operations	(45,708)		(40,628)		72		(86,264)
Other (expense) income, net (including amounts with related parties)	(848)		6,637		—		5,789
Income tax expense	—		(6)		—		(6)
Net loss	$	(46,556)	$	(33,997)	$	72	$	(80,481)


	Year ended December 31, 2020
	(Unaudited)
	NantCell		NantKwest		Intercompany Eliminations		ImmunityBio, Inc.
Revenue	$	1,695	$	111	$	(1,201)	$	605
Operating expenses:
Research and development (including amounts with related parties)	75,763		64,483		(739)		139,507
Selling, general and administrative (including amounts with related parties)	44,099		27,254		(35)		71,318
Impairment of intangible assets	10,660		—		—		10,660
Loss from operations	(128,827)		(91,626)		(427)		(220,880)
Other (expense) income, net (including amounts with related parties)	(4,401)		(752)		—		(5,153)
Income tax benefit (expense)	1,851		(5)		—		1,846
Net loss	$	(131,377)	$	(92,383)	$	(427)	$	(224,187)


	Year ended December 31, 2019
	(Unaudited)
	NantCell		NantKwest		Intercompany Eliminations		ImmunityBio, Inc.
Revenue	$	2,994	$	43	$	(835)	$	2,202
Operating expenses:
Research and development (including amounts with related parties)	62,253		49,785		(41)		111,997
Selling, general and administrative (including amounts with related parties)	28,391		18,065		—		46,456
Loss from operations	(87,650)		(67,807)		(794)		(156,251)
Other (expense) income, net (including amounts with related parties)	(6,162)		1,921		229		(4,012)
Income tax benefit	8		97		—		105
Net loss	$	(93,804)	$	(65,789)	$	(565)	$	(160,158)

Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2021

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

Basis of Presentation

The consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (U.S. GAAP) and pursuant to the rules and regulations of the SEC. The consolidated financial statements reflect all adjustments which are, in the opinion of management, necessary for a fair presentation of our financial position and results of operations.

As of December 31, 2021, the company had an accumulated deficit of $2.0 billion. We also had negative cash flows from operations of $274.4 million for the year ended December 31, 2021. The company will likely need additional capital to further fund the development of, and seek regulatory approvals for, our product candidates, and to begin to commercialize any approved products.

The consolidated financial statements have been prepared assuming the company will continue as a going concern, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of business, and do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or amounts and classification of liabilities that may result from the outcome of the uncertainty of our ability to continue as a going concern. As a result of continuing anticipated operating cash outflows, we believe that substantial doubt exists regarding our ability to continue as a going concern without additional funding or financial support. However, we believe our existing cash, cash equivalents, and investments in marketable securities, together with capital to be raised through equity offerings (including but not limited to the offering, issuance and sale by us of our common stock that may be issued and sold under an “at-the-market” sales agreement with Jefferies LLC (the ATM), of which we had $330.8 million available for future issuance as of December 31, 2021), and our potential ability to borrow from affiliated entities, will be sufficient to fund our operations through at least the next 12 months following the issuance date of the consolidated financial statements based primarily upon our Executive Chairman and Global Chief Scientific and Medical Officer’s intent and ability to support our operations with additional funds, including loans from affiliated entities, as required, which we believe alleviates such doubt. We may also seek to sell additional equity, through one or more follow-on public offerings, or in separate financings, or obtain a credit facility. However, we may not be able to secure such external financing in a timely manner or on favorable terms. Without additional funds, we may choose to delay or reduce our operating or investment expenditures. Further, because of the risk and uncertainties associated with the potential commercialization of our product candidates in development, we may need additional funds to meet our needs sooner than planned.

Principles of Consolidation

The consolidated financial statements include the accounts of the company and its subsidiaries in which the company has a controlling financial interest. The consolidated financial statements also include certain variable interest entities in which we are the primary beneficiary (as described in more detail below). For consolidated entities where we have less than 100% of ownership, we record net loss attributable to noncontrolling interest on the consolidated statements of operations equal to the percentage of the ownership interest retained in such entities by the respective noncontrolling parties. Any material intercompany transactions and balances have been eliminated upon consolidation.

If the entity is within the scope of the variable interest model and meets the definition of a variable interest entity (VIE), we consider whether we must consolidate the VIE or provide additional disclosures regarding our involvement with the VIE. If we determine that we are the primary beneficiary of the VIE, we will consolidate the VIE. This analysis is performed at the initial investment in the entity or upon any reconsideration event.

For entities we hold as an equity investment that are not consolidated under the VIE model, we consider whether our investment constitutes a controlling financial interest in the entity and therefore should be considered for consolidation under the voting interest model.

Use of Estimates

The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make certain estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. On an ongoing basis, we evaluate our estimates, including those related to the valuation of equity-based awards, deferred income taxes and related valuation allowances, preclinical and clinical trial accruals, impairment assessments, contingent value right measurement and assessments, the measurement of right-of-use assets and lease liabilities, useful lives of long-lived assets, loss contingencies, fair value measurements, and the assessment of our ability to fund our operations for at least the next 12 months from the date of issuance of these consolidated financial statements. We base our estimates on historical experience and on various other market-specific and relevant assumptions that we believe to be reasonable under the circumstances. Estimates are assessed each period and updated to reflect current information, such as the economic considerations related to the impact that the ongoing coronavirus pandemic could have on our significant accounting estimates. Actual results could differ from those estimates.

Contingencies

We record accruals for loss contingencies to the extent that we conclude it is probable that a liability has been incurred and the amount of the related loss can be reasonably estimated. We accrue for the best estimate of a loss within a range; however, if no estimate in the range is better than any other, then we accrue the minimum amount in the range. If we determine that a material loss is reasonably possible, we disclose the possible loss or range of loss, or that the amount of loss cannot be estimated at this time. We evaluate, on a quarterly basis, developments in legal proceedings and other matters that could cause a change in the potential amount of the liability recorded or of the range of potential losses disclosed. Moreover, we record gain contingencies only when they are realizable and the amount is known. Additionally, we record our rights to insurance recoveries, limited to the extent of incurred or probable losses, as a receivable when such recoveries have been agreed to with our third-party insurers and when receipt is deemed probable. This includes instances when our third-party insurers have agreed to pay, on our behalf, certain legal defense costs and settlement amounts directly to applicable law firms and a settlement fund.

Concentration of Credit Risk and Other Risks and Uncertainties

Financial instruments that potentially subject us to concentrations of risk consist principally of cash and cash equivalents, marketable securities, and a convertible note receivable.

We attempt to minimize credit risk associated with our cash and cash equivalents by periodically evaluating the credit quality of our primary financial institutions. Our investment portfolio is maintained in accordance with our investment policy. While we maintain cash deposits in FDIC insured financial institutions in excess of federally insured limits, we do not believe that we are exposed to significant credit risk due to the financial position of the depository institutions in which those deposits are held. We have not experienced any losses on such accounts.

We also monitor the creditworthiness of the borrower of the convertible promissory note. We believe that any concentration of credit risk in its convertible note receivable was mitigated in part by our ability to convert, if necessary, at the qualifying financing event or upon a payment default into shares of the senior class of equity securities of the borrower.

Product candidates developed by us will require approvals or clearances from the FDA or international regulatory agencies prior to commercial sales. There can be no assurance that any of our product candidates will receive any of the required approvals or clearances. If we were to be denied approval or clearance or any such approval or clearance was to be delayed, it would have a material adverse impact on us.

Cash, Cash Equivalents and Restricted Cash

Cash equivalents include highly liquid investments with an original maturity of three months or less from the date of purchase.

Restricted cash includes a certificate of deposit held as a substitute letter of credit for one of our leased properties. This certificate of deposit is included in other assets, on the consolidated balance sheets as the landlord is the beneficiary of the account and we are not able to access the funds during the term of the lease.

A reconciliation of cash, cash equivalents, and restricted cash is included on the consolidated statements of cash flows as of December 31, 2021, 2020 and 2019.

Marketable Securities and Other Investments

Marketable Debt Securities

We invest our excess funds in investment grade short- to intermediate-term corporate debt securities, government-sponsored securities, and foreign government bonds and classify these investments as available-for-sale. Marketable debt securities with remaining maturities of 12 months or less are classified as short-term and marketable securities with remaining maturities greater than 12 months are classified as long-term. All marketable debt securities are reported at fair value and any unrealized gains and losses are reported as a component of accumulated other comprehensive loss, on the consolidated statements of stockholders’ deficit, with the exception of unrealized losses believed to be other-than-temporary, which are recorded in interest and investment income, net, on the consolidated statements of operations. Realized gains and losses from sales of securities and the amounts, net of tax, reclassified out of accumulated other comprehensive loss, if any, are determined on a specific identification basis.

Marketable Equity Securities

Investments in mutual funds and equity securities, other than equity method investments, are recorded at fair market value, if fair value is readily determinable and any unrealized gains and losses are included in other income (expense), net, on the consolidated statements of operations. Realized gains and losses from the sale of the securities are determined on a specific identification basis and the amounts are included in other income (expense), net, on the consolidated statement of operations.

Non-Marketable Equity Securities

Prior to March 31, 2021, we owned non-marketable equity securities that were accounted for using the measurement alternative under ASC Topic 321, Investments—Equity Securities (ASC 321), because the preferred stock held by us was not considered in-substance common stock and such preferred stock did not have a readily determinable fair value. We measured the non-marketable equity investment at cost, less impairment, adjusted for observable price changes in an orderly market for an identical or similar investment of the same issuer, with such changes recognized on the consolidated statements of operations. Some factors we may consider in the impairment analysis include the extent to which the security has been in an unrealized loss position, the change in the financial condition and near-term prospects of the issuer, as well as security and industry-specific economic conditions.

Evaluating Investments for Other-than-Temporary Impairments

We periodically evaluate whether declines in fair values of our investments below their book value are other-than-temporary. This evaluation consists of several qualitative and quantitative factors regarding the severity and duration of the unrealized loss, as well as our ability and intent to hold the investment until a forecasted recovery occurs. Additionally, we assess whether we have plans to sell the security or whether it is more likely than not we will be required to sell any investment before recovery of its amortized cost basis. Factors considered include quoted market prices, recent financial results and operating trends, implied values from any recent transactions or offers of investee securities, credit quality of debt instrument issuers, other publicly available information that may affect the value of our investments, duration and severity of the decline in value, and our strategy and intentions for holding the investment. There were no other-than-temporary impairments recorded during the years ended December 31, 2021, 2020 and 2019.

Equity Method of Accounting

In circumstances where we have the ability to exercise significant influence over the operating and financial policies of a company in which we have an investment, we utilize the equity method of accounting for recording investment activity. In assessing whether we exercise significant influence, we consider the nature and magnitude of our investment, the voting and protective rights we hold, any participation in the governance of the other company and other relevant factors such as the presence of a collaborative or other business relationship. Under the equity method of accounting, we record our share of the income or loss of the other company as gain (loss) on equity method investment, in our consolidated statements of operations.

Property, Plant and Equipment, Net

Property, plant and equipment are stated at historical cost less accumulated depreciation. Historical cost includes expenditures that are directly attributable to the acquisition of the items. All repairs and maintenance are charged to net loss during the financial period in which they are incurred. Depreciation of property, plant and equipment is calculated using the straight-line method over the estimated useful lives of the assets, as follows:


Buildings						39 years
Software						3 years
Laboratory equipment						5 to 7 years
Furniture & fixtures						5 years
IT equipment						3 years
Leasehold improvements						The lesser of the lease term or life of the asset

Upon disposal of property, plant and equipment, the cost and related accumulated depreciation are removed from the consolidated financial statements and the net amount, less any proceeds, is included in other income (expense), net, on the consolidated statements of operations.

We review impairment of property, plant and equipment for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. Recoverability is measured by a comparison of the carrying amount to the future net cash flows that the assets are expected to generate. If such assets are considered to be impaired, the impairment to be recognized is measured by the amount by which the carrying amount of the assets exceeds the projected undiscounted future cash flows arising from the assets using a discount rate determined by management to be commensurate with the risk inherent to our current business model.

Business Combinations

Business combinations are accounted for using the acquisition method of accounting in accordance with ASC Topic 805, Business Combinations (ASC 805). These standards require that the total cost of acquisition be allocated to the tangible and intangible assets acquired and liabilities assumed based on their respective fair values at the date of acquisition, with the excess purchase price recorded as goodwill. The allocation of the purchase price is dependent upon certain valuations and other studies. Acquisition costs are expensed as incurred.

Contingent consideration incurred in connection with a business combination are recorded at their fair values on the acquisition date and re-measured at their fair values each subsequent reporting period until the related contingencies are resolved. The resulting changes in fair value are recorded as research and development expense, on the consolidated statements of operations and comprehensive loss. Changes in fair value reflect changes to our assumptions regarding probabilities of successful achievement of related milestones, the timing in which the milestones are expected to be achieved, and the discount rate used to estimate the fair value of the obligation.

Common Control Transactions

Transactions between us and entities where Dr. Soon-Shiong and his affiliates are the controlling stockholders are accounted for as common control transactions whereby the net assets acquired or transferred are accounted at their carrying value. Any difference between the carrying value and consideration recognized is treated as a capital transaction. Cash consideration up to the carrying value of the net assets acquired or transferred is presented as an investing activity in our consolidated statements of cash flows. Cash consideration in excess of the carrying value of the net assets acquired or transferred is presented as a financing activity in our consolidated statements of cash flows.

Intangible Assets, Net

Intangible assets acquired in a business combination are initially recognized at their fair value on the acquisition date. The in-process research and development (IPR&D) assets are required to be classified as indefinite-lived assets and are not amortized until they become definite-lived assets, upon the successful completion of the associated research and development effort. At that time, we will evaluate whether recorded amounts are impaired and make any necessary adjustments, and then determine the useful life of the asset and begin amortization. If the associated research and development effort is abandoned, the related IPR&D assets will be written-off and an impairment charge recorded. Intangible assets are tested for impairment at least annually or more frequently if indicators of potential impairment exist.

Acquired definite-lived intangible assets are amortized using the straight-line method over their respective estimated useful lives. Intangible assets, which consisted of the cost of reacquiring a technology license during 2015, were amortized using the straight-line method over an estimated useful life of 4 years. As of December 31, 2019, our definite-lived intangible assets were fully amortized.

Patents

Patent costs, including related legal costs, are expensed as incurred and recorded in selling, general and administrative expense on the consolidated statements of operations.

Fair Value of Financial Instruments

Fair value is defined as an exit price that would be received from the sale of an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. We use a three-tier fair value hierarchy to classify and disclose all assets and liabilities measured at fair value on a recurring basis, as well as assets and liabilities measured at fair value on a non-recurring basis, in periods subsequent to their initial measurement. The hierarchy requires us to use observable inputs when available, and to minimize the use of unobservable inputs, when determining fair value.

The three tiers are defined as follows:

•Level 1—Observable inputs that reflect quoted market prices (unadjusted) for identical assets or liabilities in active markets at the measurement date. Since valuations are based on quoted prices that are readily and regularly available in an active market, the valuation of these products does not entail a significant degree of judgment. Our Level 1 assets consist of bank deposits, money market funds, and marketable equity securities.

•Level 2—Observable inputs other than quoted prices in active markets that are observable either directly or indirectly in the marketplace for identical or similar assets and liabilities. Our Level 2 assets consist of corporate debt securities including commercial paper, government-sponsored securities and corporate bonds, as well as foreign municipal securities.

•Level 3—Valuations based on inputs that are unobservable and significant to the overall fair value measurement.

We utilize a third-party pricing service to assist in obtaining fair value pricing for our investments in marketable debt securities. Inputs are documented in accordance with the fair value disclosure hierarchy. The fair values of financial instruments other than marketable securities and cash and cash equivalents are determined through a combination of management estimates and third-party valuations.

During the years ended December 31, 2021, 2020 and 2019, no transfers were made into or out of the Level 1, 2 or 3 categories. We will continue to review the fair value inputs on a quarterly basis.

Collaboration Arrangements

We analyze our collaboration arrangements to assess whether they are within the scope of ASC Topic 808, Collaborative Arrangements (ASC 808). A collaborative arrangement is a contractual arrangement that involves a joint operating activity. These arrangements involve two or more parties who are active participants in the activity, and are exposed to significant risks and rewards dependent on the commercial success of the activity. This assessment is performed throughout the life of the arrangement based on changes in the responsibilities of all parties in the arrangement. To the extent the collaboration agreement is within the scope of ASC 808, we also assess whether the arrangement contains multiple elements that are within the scope of other accounting literature. If we conclude that some or all aspects of the agreement are distinct and represent a transaction with a customer, we account for those aspects of the arrangement within the scope of ASC Topic 606, Revenue from Contracts with Customers (ASC 606). Amounts that are owed by collaboration partners within the scope of ASC 808 are recognized as an offset to research and development expense as such amounts are incurred by the collaboration partner. The amounts owed to a collaboration partner are classified as research and development expense.

Our collaboration arrangements require us to acquire certain equipment for exclusive use in the joint operating activities. These equipment purchases do not have an alternative use and are therefore expensed as incurred within research and development expense.

Our collaboration arrangements are further discussed in Note 6, Collaboration and License Agreements.

Preclinical and Clinical Trial Accruals

As part of the process of preparing the consolidated financial statements, we are required to estimate expenses resulting from obligations under contracts with vendors, clinical research organizations and consultants. The financial terms of these contracts vary and may result in payment flows that do not match the periods over which materials or services are provided under such contracts.

We estimate clinical trial and research agreement-related expenses based on the services performed, pursuant to contracts with research institutions and clinical research organizations and other vendors that conduct clinical trials and research on our behalf. In accruing clinical and research-related fees, we estimate the time period over which services will be performed and activity expended in each period. If the actual timing of the performance of services or the level of effort varies from the estimate, we will adjust the accrual accordingly. Payments made under these arrangements in advance of the receipt of the related services are recorded as prepaid expenses until the services are rendered.

Transactions with Related Parties

As outlined in Note 8, Related-Party Agreements, we have various agreements with related parties. Some are billed and settled in cash monthly. Others are billed quarterly and settled in cash the following month. Monthly accruals are made for all quarterly billing arrangements.

Lease Obligations

For all leases other than short-term leases, at the lease commencement date, a right-of-use asset and a lease liability are recognized and included in operating lease right-of-use assets, net, and current and non-current operating lease liabilities, respectively, on the consolidated balance sheets. The right-of-use asset represents the right to use the leased asset for the lease term. At the commencement date, operating lease right-of-use assets and operating lease liabilities are determined based on the present value of lease payments to be made over the lease term. Leases are classified as either finance leases or operating leases. We do not currently have any leases classified as finance leases.

As the rate implicit in lease contracts are not readily determinable, we utilize its incremental borrowing rate as a discount rate for purposes of determining the present value of lease payments, which is based on the estimated interest rate at which we could borrow on a collateralized basis the amount of the lease payments in the same currency, for a similar term, in a similar economic environment. Prospectively, we will remeasure the lease liability at the net present value of the remaining lease payments using the same incremental borrowing rate that was in effect as of the lease commencement or transition date.

Operating lease right-of-use assets also include any rent paid prior to the commencement date, less any lease incentives received, and initial direct costs incurred. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. We determine the lease term by assuming the exercise of renewal options that are reasonably assured. The exercise of lease renewal options is at our sole discretion. Several of our leases have renewal options, however, the exercise of renewal is only assured for five of our current Good Manufacturing Practices (cGMP) facilities where we have made significant improvements or extended the lease.

We combine our lease components (e.g., fixed payments including rent, real estate taxes and insurance costs) with non-lease components (e.g., common-area maintenance costs and equipment maintenance costs) and as such, we account for lease and non-lease components as a single component. Lease expense also includes amounts relating to variable lease payments. Variable lease payments include amounts relating to common area maintenance and real estate taxes.

We do not recognize right-of-use assets and lease liabilities for qualifying short-term leases with an initial lease term of 12 months or less at lease inception. Such leases are expensed on a straight-line basis over the lease term. The lease term includes the non-cancellable period of the lease and any additional periods covered by either options to renew or not to terminate when the company is reasonably certain to exercise.

The depreciable life of operating right-of-use-assets and leasehold improvements is limited by the expected lease term.

Income Taxes

We recognize deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the financial reporting and tax basis of assets and liabilities, as well as for operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using the tax rates that are expected to apply to taxable income for the years in which those tax assets and liabilities are expected to be realized or settled. We record valuation allowances to reduce deferred tax assets to the amount we believe is more likely than not to be realized.

We recognize uncertain tax positions when the position will more likely than not be upheld on examination by the taxing authorities based solely upon the technical merits of the positions. We recognize interest and penalties, if any, related to unrecognized income tax uncertainties in income tax (expense) benefit, on the consolidated statement of operations. We did not have any accrued interest or penalties associated with uncertain tax positions as of December 31, 2021 and 2020.

Stock Repurchases

In 2015, the Board of Directors approved a share repurchase program (the 2015 Share Repurchase Program). As it is our intent for the repurchased shares to be retired, we have elected to account for the shares repurchased using the constructive retirement method. For shares repurchased in excess of par, we record the purchase price in excess of par value in accumulated deficit, on the consolidated balance sheet.

Revenue Recognition

We have primarily generated revenues from non-exclusive license agreements related to our cell lines, the sale of our bioreactors and related consumables and grant programs. The nonexclusive license agreements with a limited number of pharmaceutical and biotechnology companies grant them the right to use our cell lines and intellectual property for non-clinical use. These agreements generally include upfront fees and annual research license fees for such use, as well as commercial license fees for sales of the licensee products developed or manufactured using our intellectual property and cell lines. We have generated revenues from product sales of our proprietary GMP-in-a-Box bioreactors and related consumables to related parties. Additionally, we also generated revenues from grant programs.

A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account in ASC 606. A contract’s transaction price is allocated to each distinct performance obligation based on relative standalone selling price and recognized as revenue when, or as, the performance obligation is satisfied.

Under our license agreements with customers, we typically promise to provide a license to use certain cell lines and related patents, the related know-how, and future research and development data that affect the license. We have concluded that these promises represent one performance obligation due to the highly interrelated nature of the promises. We provide the cell lines and know-how immediately upon entering into the contracts. Research and development data are provided throughout the term of the contract when and if available.

The license agreements may include non-refundable upfront payments, event-based milestone payments, sales-based royalty payments, or some combination of these. The event-based milestone payments represent variable consideration and we use the most likely amount method to estimate this variable consideration. Given the high degree of uncertainly around the achievement of these milestones, we do not recognize revenue from these milestone payments until the uncertainty associated with these payments is resolved. We currently estimate variable consideration related to milestone payments to be zero and, as such, no revenue has been recognized for milestone payments. We recognize revenue from sales-based royalty payments when or as the sales occur. On a quarterly basis, we re-evaluate our estimate of milestone variable consideration to determine whether any amount should be included in the transaction price and recorded in revenue prospectively.

We also have sold our proprietary GMP-in-a-Box bioreactors and related consumables to affiliated companies. The arrangements typically include delivery of bioreactors, consumables, and providing installation service and perpetual software licenses for using the equipment. We recognize revenue when customers obtain control and can benefit from the promised goods or services, generally upon installation of the bioreactors, in an amount that reflects the consideration that we expect to receive in exchange for those goods or services. Upfront payments and fees are recorded as deferred revenue upon receipt and recognized as revenue when we satisfy our performance obligations under these arrangements.

Grant revenue is typically paid for reimbursable costs incurred over the duration of the associated research project or clinical trial and is recognized when expenses reimbursable under the grants have been incurred and payments under the grants become contractually due.

From inception through December 31, 2021, we have generated minimal revenue from non-exclusive license agreements related to our cell lines, the sale of our bioreactors and related consumables, and grant programs. We have no clinical products approved for commercial sale and have not generated any revenue from therapeutic and vaccine product candidates that are under development.

Research and Development Costs

Major components of research and development costs include cash compensation and other personnel-related expenses, stock-based compensation, depreciation and amortization expense on research and development property and equipment and intangible assets, costs of preclinical studies, clinical trials costs, including contract research organizations (CROs) and related clinical manufacturing, including contract manufacturing organizations (CMOs), costs of drug development, costs of materials and supplies, facilities cost, overhead costs, regulatory and compliance costs, and fees paid to consultants and other entities that conduct certain research and development activities on our behalf. Costs incurred in research and development are expensed as incurred.

Included in research and development costs are clinical trial and research expenses based on the services performed pursuant to contracts with research institutions and clinical research organizations and other vendors that conduct clinical trials and research on our behalf. We record accruals for estimated costs under these contracts. When evaluating the adequacy of the accrued liabilities, we analyze the progress of the preclinical studies or clinical trials, including the phase or completion of events, invoices received, contracted costs and purchase orders. Significant judgments and estimates are made in determining the accrued balances at the end of any reporting period based on the facts and circumstances known at that time. Although we do not expect the estimates to be materially different from the amounts actually incurred, if the estimates of the status and timing of services performed differ from the actual status and timing of services performed, we may report amounts that are too high or too low in any particular period. Actual results could differ from our estimates. We adjust the accruals in the period when actual costs become known.

Stock-Based Compensation

We account for stock-based compensation under the provisions of ASC Topic 718, Compensation—Stock Compensation (ASC 718). We estimate fair value of each stock option award on the date of grant using the Black-Scholes option pricing model. The Black-Scholes model requires the use of highly subjective assumptions, including, but not limited to, expected stock price volatility over the term of the awards and the expected term of the stock options. We measure the fair value of an equity-classified award at the grant date and recognize the stock-based compensation expense over the period of vesting on the straight-line basis for our outstanding share awards that do not contain a performance condition. For awards subject to performance-based vesting conditions, we assess the probability of the individual milestones under the award being achieved and stock-based compensation expense is recognized over the service period using the graded vesting method once management believes the performance criteria is probable of being met. For awards with service or performance conditions, we recognize the effect of forfeitures in compensation cost in the period that the award was forfeited. See Note 10, Stock-Based Compensation.

Sale-Leaseback Transaction

A sale-leaseback transaction occurs when an entity sells an asset it owns and immediately leases the asset back from the buyer. The seller then becomes the lessee and the buyer becomes the lessor. When entering into a sale-leaseback transaction as a seller-lessee, the requirements in ASC Topic 606, Revenue from Contracts with Customers, and all related accounting standards updates to such Topic are applied in determining whether the transfer of an asset shall be accounted for as a sale of the asset by assessing whether it satisfies a performance obligation under the contract by transferring control of an asset. If the company transfers control of an asset to the buyer-lessor, the transfer is accounted for as a sale and the company derecognizes the transferred asset. The subsequent leaseback of the asset is accounted for in accordance with ASC Topic 842, Leases, in the same manner as any third-party lease. If the company does not transfer control of an asset to the buyer-lessor, the sale-leaseback transaction is accounted for as a financing arrangement.

In September 2021, we entered into a sale transaction with Nant Capital, LLC (Nant Capital), a related party, for a building located at 557 South Douglas Street, El Segundo, California. We subsequently leased back the building for an initial seven-year lease term with an option to extend the lease for two additional seven-year periods. There is no purchase option at the end of the lease term. Since we transferred the legal title and all benefits and risks incidental to the ownership of the property to Nant Capital, we accounted for the transfer as a sale. We have classified the leaseback of the building as an operating lease and accordingly, a right-of-use asset and an operating lease liability were established on the lease commencement date that will be amortized through the end of the lease term. See Note 8, Related-Party Agreements, for further information.

Comprehensive Income (Loss)

Comprehensive income (loss) is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner sources. Comprehensive income or loss is composed of net income (loss) and other comprehensive income (loss). Our other comprehensive income or loss consists of net unrealized gains (losses) on marketable debt securities classified as available-for-sale, net of income taxes. and foreign currency translation adjustments.

Noncontrolling Interests

Noncontrolling interests are recorded for the entities that we consolidate but are not wholly-owned by the company. Noncontrolling interests are classified as a separate component of equity on the consolidated balance sheets and consolidated statements of stockholders’ deficit. Additionally, net loss attributable to noncontrolling interests is reflected separately from consolidated net loss on the consolidated statements of operations and the consolidated statements of stockholders’ deficit. We record the noncontrolling interests’ share of loss based on the percentage of ownership interest retained by the respective noncontrolling interest holders. Noncontrolling interests recorded on the consolidated financial statements result from the company’s share of GlobeImmune, Inc. (GlobeImmune), of which we controlled 69.1%, and Immunotherapy NANTibody, LLC (NANTibody), of which we controlled 60.0% as of December 31, 2021, 2020 and 2019. Noncontrolling interest stockholders are common stockholders.

GlobeImmune was determined to be a VIE as it does not have sufficient equity investment at risk to finance its operations without additional subordinated financial support and we are deemed the primary beneficiary of GlobeImmune and, accordingly, consolidates GlobeImmune into the consolidated financial statements under the VIE model. The company also supports GlobeImmune through a promissory note agreement, in which the company provides advances to GlobeImmune from time to time up to $6.0 million with a per annum interest rate of five percent (5%). As of December 31, 2021 and 2020, there were no outstanding advances due from GlobeImmune under the promissory note agreement.

GlobeImmune recognized $0.2 million of revenues for the year ended December 31, 2019, and recognized $0.7 million, $2.0 million and $7.7 million of operating expenses for the years ended December 31, 2021, 2020 and 2019, respectively. The consolidated balance sheets include approximately $0.8 million and $0.5 million of total assets and $0.0 million and $0.3 million of total liabilities as of December 31, 2021 and 2020, respectively, related to GlobeImmune.

In addition, the company held a 68.5% ownership interest in Precision Biologics, Inc. (Precision) arising from a preferred stock investment. The company ended its investment in Precision pursuant to a final settlement agreement approved by the court in 2019. Under the terms of the settlement agreement, the company deconsolidated the related assets, liabilities and noncontrolling interests of Precision. The disposition of this investment resulted in a reduction of $18.4 million in noncontrolling interests for the year ended December 31, 2019. See Note 7, Commitments and Contingencies—Litigation, for additional information.

Foreign Currencies

We have operations and holds assets in Italy and South Korea. The functional currency of the subsidiary in Italy is the Euro, based on the nature of the transactions occurring within this entity, and accordingly, assets and liabilities of this subsidiary are translated into U.S. dollars at exchange rates prevailing as of the balance sheet dates, while the operating results are translated into U.S. dollars using the average exchange rates for the period correlating with those operating results. Adjustments resulting from translating the financial statements of the foreign subsidiary into U.S. dollars are recorded as a component of other comprehensive income (loss), on the consolidated statements of comprehensive loss. Transaction gains and losses are recorded in other income (expense), net, on the consolidated statements of operations.

Basic and Diluted Net Loss per Share of Common Stock

Basic net loss per share is calculated by dividing the net loss attributable to ImmunityBio common stockholders by the weighted-average number of common shares outstanding for the period. Diluted loss per share is computed by dividing net loss attributable to ImmunityBio common stockholders by the weighted-average number of common shares, including the number of additional shares that would have been outstanding if the potential common shares had been issued and if the additional common shares were dilutive.

For all periods presented, potentially dilutive securities are excluded from the computation of fully diluted loss per share as their effect is anti-dilutive. The following table details those securities that have been excluded from the computation of potentially dilutive securities:


	As of December 31,
	2021	2020	2019
Outstanding stock options	4,124,930	4,996,284	6,080,483
Outstanding RSUs	6,515,889	466,842	1,155,808
Outstanding related-party warrants	1,638,000	1,638,000	1,638,000
Total	12,278,819	7,101,126	8,874,291

Amounts in the table above reflect the common stock equivalents of the noted instruments, including awards issued under the NantKwest 2015 Equity Incentive Plan (the 2015 Plan), the NantKwest 2014 Equity Incentive Plan (the 2014 Plan), and awards issued under the NantCell, Inc. 2015 Stock Incentive Plan (the NC 2015 Plan) that, in the case of December 31, 2021, were outstanding immediately prior to the Effective Time of the Merger and in the case of December 31, 2020 and 2019 have been adjusted to include the combined NC 2015 Plan and NantCell warrants then outstanding (in both cases adjusted using the Exchange Ratio of 0.8190). See Note 10, Stock-Based Compensation, for further information.

Segment and Geographic Information

We operate in one reporting segment focused on creating the next generation of immunotherapies to address serious unmet needs within oncology and infectious diseases. Our chief executive officer (CEO) is the chief operating decision-maker (CODM) of the company, and manages and allocates resources to our operations on a company-wide basis. Consistent with this decision-making process, our CEO uses consolidated, single-segment financial information for purposes of evaluating performance, forecasting future-period financial results, allocating resources and setting incentive targets.

We generate a portion of its revenues from outside of the U.S. Information about our revenues from the different geographic regions is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
United States	$	373	$	513	$	1,997
Europe	561		92		205
Total segment revenue	$	934	$	605	$	2,202

Recent Accounting Pronouncements

Application of New or Revised Accounting Standards – Adopted

In November 2018, the FASB issued Accounting Standards Update, or ASU, No. 2018-18, Collaborative Arrangements (Topic 808): Clarifying the Interaction between Topic 808 and Topic 606 (ASU 2018-18), which clarifies when certain transactions between collaborative arrangement participants should be accounted for as revenue under Topic 606, “Revenue from Contracts with Customers” when the counterparty is a customer. In addition, the update precludes an entity from presenting consideration from a transaction in a collaborative arrangement as customer revenue if the counterparty is not a customer for that transaction. We adopted ASU 2018-18 in the quarter ended March 31, 2020 on a prospective basis. The adoption did not have an impact on our consolidated financial statements.

In December 2019, the FASB issued ASU 2019‑12, Simplifying the Accounting for Income Taxes, or ASU 2019‑12. The amendments removed the exception to the incremental approach for intraperiod tax allocation when there is a loss from continuing operations and income or a gain from other items (e.g., discontinued operations or other comprehensive income), and the exception to the general methodology for calculating income taxes in an interim period when a year-to-date loss exceeds the anticipated loss for the year. ASU 2019‑12 also amends other aspects of accounting for income taxes to help simplify and promote consistent application of U.S. GAAP. We early adopted ASU 2019‑12 effective January 1, 2020, and it did not have a material impact on our consolidated financial statements

In June 2016, the FASB issued Accounting Standards Update (ASU) 2016‑13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments (ASU 2016-13), which requires credit losses on most financial instruments measured at amortized cost and certain other financial instruments be measured using an expected credit loss model. Under this model, entities are required to estimate credit losses over the entire contractual term of the financial instrument from the date of initial recognition of the instrument. The company adopted this guidance on the first day of the company’s fourth quarter of fiscal 2021. The adoption of ASU 2016-13 did not have any impact on our consolidated financial statements.

Application of New or Revised Accounting Standards – Not Yet Adopted

In August 2020, the FASB issued ASU 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity, which simplifies the accounting for certain financial instruments with characteristics of liabilities and equity, including convertible instruments and contracts in an entity’s own equity. Among other changes, ASU 2020-06 removes the separation models for convertible instruments with cash or beneficial conversion features. Instead, entities will account for convertible debt instruments wholly as debt, unless certain other conditions are met. ASU 2020-06 is effective for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. The adoption of the new standard is not expected to have a material impact on the company’s financial position or results of operations upon adoption.

Other recent authoritative guidance issued by the FASB (including technical corrections to the ASC), the American Institute of Certified Public Accountants, and the SEC during the three months ended December 31, 2021 did not, or are not expected to, have a material effect on our consolidated financial statements.

Financial Statement Details

12 Months Ended

Dec. 31, 2021

Financial Statement Details [Abstract]

Financial Statement Details

Property, Plant and Equipment, Net

Property, plant and equipment, net, consist of the following (in thousands):




	As of December 31,
	2021		2020
Leasehold improvements	$	62,482	$	52,251
Equipment	54,284		34,738
Construction in progress	16,575		1,333
Software	1,544		2,376
Furniture & fixtures	1,052		1,015
Building	—		22,690
Gross property, plant and equipment	135,937		114,403
Less: Accumulated depreciation and amortization	53,074		41,862
Property, plant and equipment, net	$	82,863	$	72,541

In September 2021, we entered into a sale transaction with Nant Capital, a related party, for a building located at 557 South Douglas Street, El Segundo, California. We subsequently leased back the building for an initial seven-year lease term with an option to extend the lease for two additional seven-year periods. The net proceeds from the transaction totaled $21.9 million and the net carrying value of the building was $20.5 million at the time of the transaction. We accounted for the transfer as a sale of an asset to an entity under common control, recorded the transfer at book value and recognized the excess of net consideration over carrying book value of $1.4 million as a capital contribution received from Nant Capital. See Note 8, Related-Party Agreements, for further information.

Depreciation and amortization expense related to property, plant and equipment totaled $14.2 million, $12.7 million and $14.0 million for the years ended December 31, 2021, 2020 and 2019, respectively.

Intangible Assets, Net

As of December 31, 2021 and 2020, the company only had indefinite-lived IPR&D intangible assets, which were obtained from business acquisitions. During 2020, we determined to discontinue the LMP1 and LMP/IPS programs based on the results gathered from the preclinical data during the third quarter of 2020. As a result, the carrying value of the IPR&D relating to the LMP1 and LMP/IPS program was written down to zero and we recorded an impairment charge of $10.7 million on the consolidated statement of operations. No such charges were recorded during the years ended December 31, 2021 and 2019.

Convertible Note Receivable

In 2016, we executed a convertible promissory note with Riptide Bioscience, Inc., or Riptide, and advanced Riptide a principal amount of $5.0 million. The note bears interest at a per annum rate of five percent (5%). The original term of the promissory note requires that the entire unpaid principal amount and all unpaid accrued interest shall become fully due and payable upon the earlier of (i) the three (3) year anniversary of the issuance date, and (ii) when we accelerate the maturity of the note upon the occurrence of an event of default. In the event of qualified financing, the outstanding principal amount and unpaid accrued interest automatically convert into the most senior class of preferred stock sold in such qualified financing at a 25% discount to the price per share paid for such preferred stock. In addition, in the event of a change in control, we have the option to be paid in cash or to convert, immediately prior to the closing of such transaction, the outstanding indebtedness into Riptide’s most senior class of equity securities at a 25% discount to the price per share paid for such equity securities in such transaction.

Concurrent with the transaction, we entered into an exclusive license agreement with Riptide to obtain worldwide exclusive rights, with the right to sublicense, certain know-how related to RP-182, RP-233 and RP-183. We are required to pay a single-digit royalty on net sales of the licensed products on a country-by-country basis. Pursuant to the license agreement, we are also required to make cash milestone payments upon successful completion of certain clinical, regulatory and commercial milestones up to an aggregate amount of $47.0 million for the first three indications of the licensed product with a maximum payment amount of $100.0 million.

In 2019, we and Riptide entered into a first amendment to the convertible promissory note. Under the agreement, we extended the maturity of the promissory note to the earlier of, a) the later of, i) the completion of non-clinical IND enabling studies by the company, or ii) December 31, 2020; and b) when we accelerate the maturity of the note upon the occurrence of an event of default. No other terms and conditions of the promissory note were modified. Concurrently, we also entered into a first amendment to the exclusive license agreement with Riptide and extended the achievement dates for certain clinical trial milestones related to the licensed products. This option for receiving a 25% discount was determined to have an immaterial value at inception and life to date of the note, as the probability of a future qualifying event is remote. All other terms and conditions of the license agreement continued in full force and effect. This promissory note is still outstanding as of December 31, 2021. The convertible note receivable balance was $6.4 million and $6.1 million, which included accrued interest of $1.4 million and $1.1 million as of December 31, 2021 and 2020, respectively

Accrued Expenses and Other Liabilities

Accrued expenses and other liabilities consist of the following (in thousands):




	As of December 31,
	2021		2020
Accrued bonus	$	8,316	$	5,288
Accrued construction costs	8,145		—
Accrued dissenting shares (Note 7)	7,118		6,769
Accrued professional and service fees	6,909		7,668
Accrued preclinical and clinical trial costs	5,842		4,339

Accrued compensation	5,613		3,891








Other	9,444		8,816
Accrued expenses and other liabilities	$	51,387	$	36,771

Interest and Investment (Loss) Income, Net

Interest and investment (loss) income, net consists of the following (in thousands):


	Year Ended December 31,
	2021		2020		2019
Unrealized (losses) gains from equity securities	$	(4,615)	$	1,577	$	(321)
Interest income	836		1,725		2,764
Investment (amortization expense) accretion income, net	(488)		(858)		3
Net realized gains (losses) on investments	167		(9)		(4)
Interest and investment (loss) income, net	$	(4,100)	$	2,435	$	2,442

Interest income includes interest from marketable securities, convertible notes receivable, other assets, and on bank deposits.

Financial Instruments

12 Months Ended

Dec. 31, 2021

Investments, Debt and Equity Securities [Abstract]

Financial Instruments

Investments in Marketable Debt Securities

As of December 31, 2021, the weighted-average remaining contractual life, amortized cost, gross unrealized gains, gross unrealized losses and fair value of marketable debt securities, which were considered as available-for-sale, by type of security were as follows (in thousands):


	December 31, 2021
	Weighted- Average Remaining Contractual Life (in years)	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Current:
Corporate debt securities	0.5	$	129,190	$	10	$	(36)	$	129,164
Foreign bonds	0.4	116		—		(1)		115
Mutual funds		35		3		—		38
Current portion		129,341		13		(37)		129,317
Noncurrent:
Foreign bonds	5.0	719		103		—		822
Noncurrent portion		719		103		—		822
Total		$	130,060	$	116	$	(37)	$	130,139

As of December 31, 2020, the amortized cost, gross unrealized gains, gross unrealized losses and fair value of marketable debt securities, which were considered as available-for-sale, by type of security were as follows (in thousands):


	December 31, 2020
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Current:
Corporate debt securities	$	54,789	$	2	$	(19)	$	54,772
Mutual funds	35		2		—		37
Current portion	54,824		4		(19)		54,809
Noncurrent:
Foreign bonds	861		89		—		950
Noncurrent portion	861		89		—		950
Total	$	55,685	$	93	$	(19)	$	55,759

Accumulated unrealized losses on marketable debt securities that have been in a continuous loss position for less than 12 months and more than 12 months were as follows (in thousands):


	December 31, 2021
	Less than 12 months				More than 12 months
	Estimated Fair Value		Gross Unrealized Losses		Estimated Fair Value		Gross Unrealized Losses
Corporate debt securities	$	86,158	$	(36)	$	—	$	—
Mutual funds	—		—		34		(2)
Foreign bonds	115		(1)		113		(1)
Total	$	86,273	$	(37)	$	147	$	(3)


	December 31, 2020
	Less than 12 months				More than 12 months
	Estimated Fair Value		Gross Unrealized Losses		Estimated Fair Value		Gross Unrealized Losses
Corporate debt securities	$	42,762	$	(19)	$	—	$	—
Total	$	42,762	$	(19)	$	—	$	—

We evaluated our securities for other-than-temporary impairment, and we did not recognize any other-than-temporary impairment losses for the years ended December 31, 2021, 2020 and 2019.

Realized gains and losses on sales of available-for-sale marketable debt securities were not significant for the years ended December 31, 2021, 2020 and 2019.

Marketable Equity Securities

We held investments in marketable equity securities with readily determinable fair values of $6.7 million and $6.3 million as of December 31, 2021 and 2020, respectively. Unrealized losses recorded on these securities totaled $4.6 million and $0.3 million for the years ended December 31, 2021 and 2019, and an unrealized gain recorded on these securities totaled $1.6 million for the year ended December 31, 2020, respectively, in interest and investment (loss) income, net, on the consolidated statements of operations. We recorded a realized gain totaling $0.2 million from sales of marketable equity securities in interest and investment (loss) income, net, on the consolidated statement of operations for the year ended December 31, 2021.

Non-Marketable Equity Securities

In 2017, we participated in a Series B convertible preferred stock financing and invested $8.5 million in Viracta Therapeutics, Inc. (Viracta), a clinical-stage drug development company with whom we have an exclusive worldwide license to develop and commercialize one of their proprietary drug candidates, which was initially recorded at cost. In 2018, we purchased additional convertibles notes totaling $0.7 million, which could be converted into preferred stock of Viracta under certain circumstances. Effective in early 2019, the notes, together with accrued interest then outstanding, were converted to Series B preferred stock resulting in an increase to our investment in Viracta’s Series B convertible preferred stock of $0.8 million. In 2019, we exercised warrants to acquire 253,120 shares of Viracta common stock.

We have elected to apply the measurement alternative under ASC 321, pursuant to which we measure our investment in Viracta at cost, less impairment, adjusted for observable price changes in an orderly market for an identical or similar investment of the same issuer, with such changes recognized on the consolidated statements of operations.

On December 31, 2020, we reduced the carrying value by $1.4 million due to the observable price change, which was included in other income (expense), net, on the consolidated statements of operations. As of December 31, 2020, the carrying value of our investment in Viracta, which is reflected in non-marketable equity investment, on the consolidated balance sheets, totaled $7.8 million.

In February 2021, Viracta merged with Sunesis Pharmaceuticals, Inc. (Sunesis), a public company. In connection with this transaction, our preferred stock investment in Viracta was converted into 1,562,604 shares of Viracta common stock effective February 25, 2021. The fair value of investment is accounted as marketable equity securities and is reflected in marketable securities, on the consolidated balance sheets, totaled $5.7 million as of December 31, 2021.

Fair Value Measurements

12 Months Ended

Dec. 31, 2021

Fair Value Disclosures [Abstract]

Fair Value Measurements

Recurring Valuations

Financial assets and liabilities measured at fair value on a recurring basis are summarized below (in thousands):


	Fair Value Measurements at December 31, 2021
	Total			Level 1		Level 2		Level 3
Assets:
Current:
Cash and cash equivalents	$	181,101	(1)	$	51,421	$	129,680	$	—
Equity securities	6,698		(2)	6,698		—		—
Corporate debt securities	129,164			—		129,164		—
Foreign bonds	115			115		—		—
Mutual funds	38			38		—		—
Noncurrent:
Foreign bonds	822			822		—		—
Total assets measured at fair value	$	317,938		$	59,094	$	258,844	$	—
Liabilities:
Contingent consideration	$	(409)	(3)	$	(388)	$	—	$	(21)


	Fair Value Measurements at December 31, 2020
	Total			Level 1		Level 2		Level 3
Assets:
Current:
Cash and cash equivalents	$	34,915		$	34,915	$	—	$	—
Corporate debt securities	54,772			—		54,772		—
Equity securities	6,337			6,337		—		—
Mutual funds	37			37		—		—
Noncurrent:
Foreign bonds	950			950		—		—
Total assets measured at fair value	$	97,011		$	42,239	$	54,772	$	—
Liabilities:
Contingent consideration	$	(972)	(3)	$	—	$	—	$	(972)

_______________


(1)			Amounts shown as a Level 2 measurement include government-sponsored securities of $75.0 million, corporate debt securities of $54.2 million, and commercial paper of $0.5 million with original maturities of less than 90 days.


(2)			Our equity securities include a $5.7 million investment in Viracta. As of December 31, 2020, the carrying value of our investment in Viracta, which was reflected in non-marketable equity investment, on the consolidated balance sheets, was $7.8 million.


(3)			Contingent consideration is recorded at estimated fair value and revalued each reporting period until the related contingency is resolved. The fair value measurement is based on inputs that are unobservable and significant to the overall fair value measurement (i.e., a Level 3 measurement within the fair value hierarchy) and are reviewed periodically by management. See Note 7, Commitments and Contingencies—Contingent Consideration Related to Business Combinations, for further information.

Changes in the carrying amount of contingent consideration were as follows (in thousands):


	For the Year Ended December 31,
	2021		2020		2019
Fair value, beginning of year	$	(972)	$	(1,725)	$	(1,004)
Consideration paid	419		—		(786)
Net decrease in fair value	144		753		65
Fair value, end of year	$	(409)	$	(972)	$	(1,725)

Non-Recurring Valuations

Non-financial assets and liabilities are recognized at fair value subsequent to initial recognition when they are deemed to be other-than-temporarily impaired. There were no material non-financial assets and liabilities deemed to be other-than-temporarily impaired and measured at fair value on a non-recurring basis for the years ended December 31, 2021, 2020 and 2019.

Collaboration and License Agreements	12 Months Ended
Collaboration and License Agreements	Dec. 31, 2021
Research and Development [Abstract]
Collaboration and License Agreements	Collaboration and License Agreements Collaboration Agreements National Cancer Institute 2015 NCI CRADA In May 2015, Etubics Corporation (Etubics) entered into a Cooperative Research and Development Agreement (CRADA) with the U.S. Department of Health and Human Services (HHS) as represented by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to collaborate on the preclinical and clinical development of an adenovirus technology expressing tumor-associated antigens for cancer immunotherapy. In January 2016, we acquired all of the outstanding equity interests in Etubics and Etubics became a wholly-owned subsidiary. Effective January 2018, our subsidiary NantCell assumed the CRADA and it was amended to cover a collaboration for the preclinical and clinical development of our proprietary yeast-based Tarmogens expressing tumor-associated antigens and proprietary adenovirus technology expressing tumor-associated antigens for cancer immunotherapy. Pursuant to the CRADA, the NCI provides scientific staff and other support necessary to conduct research and related activities as described in the CRADA. During the term of the CRADA, we were required to make annual payments of $0.6 million to the NCI for support of research activities. We made payments of $0.6 million in each of the years ended December 31, 2021 and 2020, respectively, and recorded $0.6 million in research and development expense, on the consolidated statements of operations for the years ended December 31, 2021 and 2020. In November 2021, NantCell entered into a third amendment to the CRADA, which was effective as of March 16, 2021. The principal changes effected by the third amendment are the following: (i) assignment of the CRADA from NantCell to ImmunityBio; (ii) modification of the research plan; (iii) extension of the CRADA term through May 2026; and (iv) an increase in funding for a total of $1.3 million per year, payable in semi-annual installments from 2022 through 2025. Pursuant to the updated CRADA research plan, NCI and ImmunityBio will collaborate on the preclinical and clinical development of ImmunityBio’s proprietary adenovirus platform expressing tumor-associated antigens; proprietary yeast platform expressing tumor-associated antigens; proprietary agent Anktiva and derivatives, agent N-808 and derivatives, and/or TxM product candidates; proprietary recombinant NK cells and mAbs; proprietary RNA vaccines and adjuvants; and other proprietary agents owned or controlled by ImmunityBio as contemplated in the research plan, for cancer immunotherapy. In accordance with the terms of the amended CRADA, the company is required to make an additional $0.7 million payment within 30 days of the execution date in addition to a $0.6 million payment to the NCI for support of research activities during 2021. We made a payment of $0.7 million and recorded an additional $0.5 million for the third amendment in research and development expense, on the consolidated statement of operations for the year ended December 31, 2021. National Institute of Deafness and Communication Disorders 2021 NIDCD CRADA In February 2021, we entered into a CRADA with HHS as represented by the National Institute of Deafness and Communication Disorders (NIDCD) of the NIH to conduct collaborative analysis of human clinical trial samples from clinical trials using our proprietary recombinant NK cells and/or mAbs for preclinical development in monotherapy and in combination immunotherapies. The CRADA has a two-year term commencing on February 22, 2021 and expiring on February 22, 2023. During the term of the agreement, we are required to provide $0.1 million per year to the NIDCD for support of the research activities. We made a payment of $0.1 million during the year ended December 31, 2021. Under any of the CRADAs, any party may unilaterally terminate the agreement by providing timely advance written notice to the other party before the desired termination date. Pursuant to the terms of the CRADAs, we have an option to elect to negotiate an exclusive or non-exclusive commercialization license to any inventions discovered in the performance of any of the CRADAs. The parties jointly own any inventions and materials that are jointly produced by employees of both parties in the course of performing activities under the CRADAs. Amyris Joint Venture In December 2021, ImmunityBio and Amyris, Inc. (Amyris) entered into a 50:50 joint venture arrangement and formed a new limited liability company to conduct the business of the joint venture, to accelerate the commercialization of a next-generation COVID-19 vaccine utilizing IDRI’s RNA vaccine platform to which Amyris holds a license. As part of the limited liability agreement, we agreed to contribute $1.0 million in cash and priority access to our manufacturing capacity for the joint venture product. Amyris contributed $1.0 million in cash and rights to its license agreement with IDRI for the IDRI RNA platform for the field of COVID-19. The value of the manufacturing access right and the license right was determined by the board of directors of the joint venture to be $9.0 million, respectively. Both parties agreed to enter into a separate manufacturing and supply agreement and a sublicense agreement within 90 days of the execution of the joint venture agreement. Both parties agreed to make additional capital contributions in cash, in proportion to their respective interests, as determined by the board of directors of the joint venture (two members appointed by us and two members appointed by Amyris). The joint venture agreement stipulates the initial terms for equal representation in the management of the newly-formed joint venture. We considered the joint venture entity as a VIE and determined that we are not the primary beneficiary of the VIE. We accounted for the joint venture using the equity method of accounting, and recorded our 50% share of the net loss from the joint venture totaling $0.8 million in other expense, net, on the consolidated statement of operations for the year ended December 31, 2021. License Agreements EnGeneIC Licensing Agreement During the fourth quarter of 2021, we signed a binding term sheet with EnGeneIC for an exclusive, worldwide license to develop, manufacture and commercialize their patented EDV nanocell technology as a single agent in certain cancer fields and with respect to the treatment and prevention of COVID-19 and in combination with our COVID-19 vaccine and anti-cancer drugs in a more broadly defined field of use. The companies have agreed to a 50:50 split of the net profit from worldwide sales of EDV-based products, and we have agreed to pay certain periodic license fees. Infectious Disease Research Institute In May 2021, we entered into two license agreements with the Infectious Disease Research Institute (IDRI) pursuant to which we received a license to certain patents and know-how relating to IDRI’s (i) adjuvant formulations for the treatment, prevention and/or diagnosis of SARS-CoV-2 (the IDRI Adjuvant Formulation License Agreement) and (ii) RNA vaccine platform as further described below (the IDRI RNA License Agreement). Under both agreements, we were obligated to pay one-time, non-creditable, non-refundable upfront cash payments totaling $2.0 million. In addition, under the IDRI Adjuvant Formulation License Agreement we owe IDRI milestone payments to a total of up to $2.5 million based on the achievement of certain development and regulatory milestones for the first licensed product and royalties on annual net sales of licensed products on a country-by-country and product-by-product basis of a low-single digit percentage, subject to certain royalty-reduction provisions. Under these agreements, we made a $2.0 million upfront payment and recognized $2.0 million in research and development expense, on the consolidated statement of operations, and no milestone fees were incurred for the year ended December 31, 2021. In September 2021, we amended and restated the IDRI RNA License Agreement, pursuant to which IDRI granted us an exclusive, worldwide, sublicensable license to IDRI’s rights to an RNA vaccine platform for the development and commercialization of certain therapeutic, diagnostic or prophylactic products for the prevention, treatment or diagnosis of any indication, other than those subject to pre-existing third-party license grants, including, without limitation, SARS-CoV-2. Pursuant to the terms of the amended and restated IDRI RNA License Agreement, we were required to make an additional one-time, non-creditable, non-refundable, upfront payment to IDRI of $1.5 million. The company is also required to pay license maintenance fees to IDRI as follows: $3.0 million in 2022 and $5.5 million annually from 2023 through 2030. The company may terminate the restated agreement without cause by paying IDRI a $10.0 million one-time early termination fee. In addition, the milestone payments to IDRI based on the achievement of certain development and regulatory milestones for the first licensed product were amended to a total of up to $4.0 million. We are required to pay royalties on annual net sales of licensed products on a country-by-country and product-by-product basis of a low to mid-single digit percentage. We made a payment of $1.5 million and recorded in research and development expense, on the consolidated statement of operations for the year ended December 31, 2021. In connection with the license agreements, in May 2021 we also entered into a sponsored research agreement (SRA) with IDRI pursuant to which we will fund continued research of at least $2.0 million per year, payable in four equal quarterly installments each year until May 2024, or such year of earlier termination. For the year ended December 31, 2021, we recorded $1.2 million in research and development expense, on the consolidated statement of operations related to the SRA. Viracta License Agreement In 2017, we entered into an agreement with Viracta under which we were granted exclusive worldwide rights to Viracta’s Phase 2 drug candidate, VRx-3996 (nanatinostat), for use in combination with our platform of NK cell therapies. In consideration for the license, we are obligated to pay Viracta mid-single digit percentage royalties on net sales of licensed products for therapeutic use and milestone payments ranging from $10.0 million to $25.0 million up to an aggregate maximum of $100.0 million for various regulatory approvals and cumulative net sales levels. We may terminate the agreement, at our sole discretion, in whole or on a product by product and/or country by country basis, at any time upon 90 days’ prior written notice. In addition, either party may terminate the agreement in the event of a material breach or for bankruptcy of the other party. To date, we have not had incurred any royalty or milestone payment obligations under this agreement, including during the years ended December 31, 2021, 2020 and 2019.

Commitments and Contingencies

12 Months Ended

Dec. 31, 2021

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

Contingent Consideration Related to Business Combinations

VivaBioCell, S.p.A.

In April 2015, NantWorks, LLC (NantWorks), a related party, acquired a 100% interest in VivaBioCell, S.p.A. (VivaBioCell) through its wholly-owned subsidiary, VBC Holdings, LLC, (VBC Holdings) for $0.7 million, less working capital adjustments. In June 2015, NantWorks contributed its equity interest in VBC Holdings to the company, in exchange for cash consideration equal to its cost basis in the investment. VivaBioCell develops bioreactors and products based on cell culture and tissue engineering in Italy.

In connection with our acquisition of VBC, we are obligated to pay the former owners contingent consideration upon the achievement of certain milestones related to the GMP-in-a-Box technology. A clinical milestone totaling $0.8 million was earned by the former owners of VivaBioCell, of which $0.4 million was paid during the year ended December 31, 2021. The remaining $0.4 million was accrued as of December 31, 2021 and is expected to be paid in 2022. If the regulatory milestone is achieved, we are obligated to pay approximately $2.3 million.

Altor BioScience Corporation

In connection with the 2017 acquisition of Altor BioScience Corporation (Altor), we issued contingent value rights (CVRs) under which we agreed to pay the prior stockholders of Altor approximately $304.0 million upon successful approval of the Biologics License Application (BLA) or foreign equivalent, for Anktiva by December 31, 2022 and approximately $304.0 million upon the first calendar year before December 31, 2026 in which worldwide net sales of Anktiva exceed $1.0 billion (with amounts payable in cash or shares of our common stock or a combination thereof). Dr. Soon-Shiong and his related party hold approximately $279.5 million in the aggregate of CVRs and they have both irrevocably agreed to receive shares of the company’s common stock in satisfaction of their CVRs. We may be required to pay the other prior Altor stockholders up to $164.2 million in settlement of the CVRs relating to the regulatory milestone and up to $164.2 million of the CVRs relating to the sales milestone should they choose to have the CVRs paid in cash instead of common stock. As the transaction was recorded as an asset acquisition, future CVR payments will be recorded when the corresponding events are probable of achievement or the consideration becomes payable.

Litigation

From time to time, we may be involved in various claims and legal proceedings relating to claims arising out of our operations. We are not currently a party to any legal proceedings that, in the opinion of our management, are likely to have a material adverse effect on our business. We are aware of complaints that have been filed regarding the Merger, but we have not been served with any of such complaints. If we are served with any such complaints, we will assess at that time any contingencies for which we may need to reserve. Regardless of the outcome, litigation can have an adverse impact on us because of defense and settlement costs, diversion of management resources and other factors.

Altor BioScience, LLC Litigation

In 2017, NantCell announced it had entered into a definitive merger agreement to acquire Altor BioScience Corporation. An action captioned Gray v. Soon-Shiong, et al. was filed in Delaware Chancery Court by plaintiffs Clayland Boyden Gray (Gray) and Adam R. Waldman. The plaintiffs, two minority stockholders, asserted claims against the company and other defendants for (1) breach of fiduciary duty and (2) aiding and abetting breach of fiduciary duty and filed a motion to enjoin the merger. The court denied the motion and permitted the merger to close.

Subsequent to the close of the merger, in 2017 the plaintiffs (joined by two additional minority stockholders, Barbara Sturm Waldman and Douglas E. Henderson (Henderson)) filed a second amended complaint, asserting claims for (1) appraisal; (2) quasi-appraisal; (3) breach of fiduciary duty; and (4) aiding and abetting breach of fiduciary duty. The defendants moved to dismiss the second amended complaint, raising grounds that included a “standstill” agreement under which defendants maintained that Gray and Adam R. Waldman and Barbara Strum Waldman (the Waldmans) agreed not to bring the lawsuit.

In a second action, Dyad Pharmaceutical Corporation (Dyad) filed a petition in Delaware Chancery Court for appraisal in connection with the merger. Respondent moved to dismiss the appraisal petition in 2018, arguing in part that the petition was barred by the same “standstill” agreement. In 2018, the court heard oral arguments on the motions to dismiss in both consolidated cases and converted the motions to dismiss into motions for summary judgment with regard to the “standstill” agreement argument (the Converted Motions).

The court issued an oral ruling in 2019 that dismissed certain claims and dismissed Altor BioScience from the action. The following claims remained: (a) the appraisal claims by all plaintiffs and Dyad (against Altor BioScience, LLC), and (b) Henderson’s claims for breach of fiduciary duty and aiding and abetting breach of fiduciary duty.

In 2019, the court issued a written order implementing its ruling on the Converted Motions (the Implementing Order). In the Implementing Order, the court confirmed that all fiduciary duty claims brought by Gray, both individually and as trustee of the Gordon Gray Trust f/b/o C. Boyden Gray, were dismissed. Gray and the Waldmans filed answers denying the counterclaims and asserting defenses. The plaintiffs then moved for leave to file a third amended complaint to add two former Altor stockholders as plaintiffs and a fiduciary duty claim on behalf of a purported class of former Altor stockholders, which the defendants opposed.

In 2020, the court granted the plaintiffs’ motion, and the plaintiffs filed the third amended complaint. In 2020, the defendants answered the third amended complaint and asserted counter claims against the plaintiffs. The defendants are seeking damages for attorneys’ fees and costs incurred as a result of the breaches of the “standstill” agreements discussed above and of stockholder releases. The plaintiffs filed an answer denying the counterclaims and asserting defenses. Trial was set to commence on August 8, 2022, but the parties have received notice that the Vice Chancellor assigned to the case is retiring, and there may be a new trial date.

The shares of the former Altor stockholders seeking appraisal met the definition of dissenting shares under the merger agreement and were not entitled to receive any portion of the merger consideration at the closing date. However, these dissenting shares will automatically be converted to receive the portion of the merger consideration they were entitled to, on the later of the closing date or when the stockholder withdraws or loses the right to demand appraisal rights. Payment for dissenting shares will be on the same terms and conditions originally stated in the merger agreement.

As of December 31, 2021 and 2020, we had accrued $7.1 million and $6.8 million, respectively, related to the dissenting share obligations. The accrued amount represents the estimated low-end of the range of currently estimated payout amounts in accordance with ASC Topic 450, Contingencies, after considering the reasonable outcomes for settling the dissenting stockholder dispute along with any accrued statutory interest. We cannot reasonably estimate a range of loss or likelihood of loss beyond the amounts recorded for dissenting shares as of December 31, 2021, as the dissenting stockholders have not yet provided a quantified value of their claim and, therefore, an upper end of the range of loss cannot be determined. Discovery is ongoing, and the class certification motion relating to the putative class has not yet been decided. We reassess the reasonableness of the recorded amount at each reporting period. We believe the claims lack merit and intend to continue defending the case vigorously.

Sorrento Therapeutics, Inc. Litigation

Sorrento Therapeutics, Inc. (Sorrento), derivatively on behalf of NANTibody, filed an action in the Superior Court of California, Los Angeles County (the Superior Court) against the company, Dr. Soon-Shiong and Charles Kim. The action alleged that the defendants improperly caused NANTibody to acquire IgDraSol, Inc. from our affiliate NantPharma, LLC (NantPharma) and sought to have the transaction undone and the purchase amount returned to NANTibody. In 2019, we filed a demurrer to several causes of action alleged in the Superior Court action, and Sorrento filed an amended complaint, eliminating Mr. Kim as a defendant and dropping the causes of action we had challenged in our demurrer.

Sorrento filed a related arbitration proceeding (the Cynviloq arbitration) against Dr. Soon-Shiong and NantPharma; the company is not named in the Cynviloq arbitration. In 2020, the Superior Court granted Dr. Soon-Shiong’s request for a preliminary injunction barring Sorrento from pursuing claims against him in the Cynviloq arbitration. Sorrento then filed the claims it had previously asserted in arbitration against Dr. Soon-Shiong in the Superior Court, and at Sorrento’s request, the arbitrator entered an order dismissing Sorrento’s claims against Dr. Soon-Shiong in the Cynviloq arbitration. The hearing in the Cynviloq arbitration commenced in June 2021, and continued with breaks until early October 2021. The parties are now engaged in post-hearing briefing, and it is expected that summations will be scheduled in mid-July 2022.

Also in 2019, the company and Dr. Soon-Shiong filed cross-claims in the Superior Court action against Sorrento and its Chief Executive Officer Henry Ji, asserting claims for fraud, breach of contract, breach of the covenant of good faith and fair dealing, tortious interference with contract, unjust enrichment, and declaratory relief. Our claims allege that Dr. Ji and Sorrento breached the terms of an exclusive license agreement between the company and Sorrento related to Sorrento’s antibody library and that Sorrento did not perform its obligations under the exclusive license agreement. The Superior Court ruled that the company’s claims should be pursued in arbitration and that Dr. Soon-Shiong’s claims could be pursued in Superior Court.

In 2019, the company, along with NANTibody, filed an arbitration against Sorrento and Dr. Ji asserting our claims relating to the exclusive license agreement. In 2020, Sorrento sent letters purporting to terminate the exclusive license agreement with the company, and an exclusive license agreement with NANTibody and demanding the return of its confidential information and transfer of all regulatory filings and related materials. As required pursuant to the exclusive license agreements, both parties must engage in good-faith negotiations before attempting to invoke any termination provision contained in the agreement. Notwithstanding such negotiations, Sorrento sent a letter purporting to terminate the exclusive license agreements, maintaining the negotiations did not reach a successful resolution. We believe we have cured any perceived breaches during the 90-day contractual cure period provided under the agreements. Sorrento filed counterclaims against the company and NANTibody in the arbitration and requested leave to file a dispositive motion. The hearings in the NANTibody arbitration commenced in April 2021 and concluded in early August 2021. After post-hearing briefing was concluded, the parties were notified on November 30, 2021 that the arbitrator in the NANTibody arbitration had passed away. A substitute arbitrator was appointed on February 25, 2022, and the parties will work with the substitute arbitrator to conclude the proceedings. We intend to prosecute our claims, and to defend the claims asserted against us, vigorously. An estimate of the possible loss or range of loss cannot be made at this time.

Shenzhen Beike Biotechnology Co. Ltd. Arbitration

In 2020, we received a Request for Arbitration before the International Chamber of Commerce, International Court of Arbitration. The arbitration relates to a license, development, and commercialization agreement that Altor entered into with Beike in 2014, which agreement was amended and restated in 2017, pursuant to which Altor granted to Beike an exclusive license to use, research, develop and commercialize products based on Anktiva in China for human therapeutic uses. In the arbitration, Beike is asserting a claim for breach of contract under the license agreement. Among other things, Beike alleges that we failed to use commercially reasonable efforts to deliver to Beike materials and data related to Anktiva. Beike is seeking specific performance, or in the alternative, damages for the alleged breaches. On September 25, 2020, the parties entered into a standstill and tolling agreement under which, among other things, the parties affirmed they will perform certain of their obligations under the license agreement by specified dates and agreed that all deadlines in the arbitration are indefinitely extended. The standstill agreement may be terminated by any party on ten calendar days’ notice, and upon termination, the parties will have the right to pursue claims arising from the license agreement in any appropriate tribunal. The parties have been providing periodic updates to the International Chamber of Commerce confirming a stay of all proceedings during the standstill. Given that this action remains at the pleading stage and no discovery has occurred, it remains too early to evaluate the likely outcome of the case or to estimate any range of potential loss. We believe the claims lack merit and intend to defend the case vigorously and that we may have counterclaims.

Fox Chase Cancer Center Foundation Litigation

In, 2020, ImmunityBio filed a declaratory judgment lawsuit in the Superior Court for San Diego County, California, naming Fox Chase Cancer Center Foundation and Institute for Cancer Research (ICR) as the defendants (hereafter collectively Fox Chase). This litigation relates to the license with Fox Chase and includes various intellectual property rights (the 2004 License). Our initial court filing requested the Court to find that we have not breached material obligations under the 2004 License and that Fox Chase has not and cannot terminate the 2004 License. Fox Chase filed a Cross-Complaint raising a patent inventorship challenge and moved the case to federal court. On June 4, 2021, the federal court separated the parties’ claims, and returned ImmunityBio’s declaratory judgment claims back to the San Diego County court but retained the patent inventorship challenge. On November 18, 2021, we reached a settlement with Fox Chase related to the 2004 License and agreed to a mechanism for addressing the patent inventorship dispute. There was no financial impact to the company with respect to this settlement.

Litigation Related to the Merger with ImmunityBio, Inc.

In connection with the Merger with NantCell, Inc. (formerly known as ImmunityBio, Inc., a private company), a Delaware corporation, via a wholly-owned subsidiary of NantKwest (the Merger Sub), seven complaints have been filed as individual actions in United States District Courts. Three complaints have been filed in the United States District Court for the District of Delaware against NantKwest and its directors and are captioned Hargett v. NantKwest, Inc., et al., 1:21‑cv‑00197 (filed February 11, 2021) (the Hargett Complaint), Franchi v. NantKwest, Inc., et al., 1:21‑cv‑00218 (filed February 16, 2021) (the Franchi Complaint), and Gross v. NantKwest, Inc., et al., 1:21‑cv‑00223 (filed February 17, 2021) (the Gross Complaint). One complaint has been filed in the United States District Court for the Southern District of New York and is captioned Leaman v. NantKwest, Inc., et al., 1:21‑cv‑01351 (filed February 16, 2021) (the Leaman Complaint). Two complaints have been filed in the United States District Court for the Southern District of California and are captioned Weiss v. NantKwest, Inc., et al., 3:21‑cv‑00280 (filed February 16, 2021) (the Weiss Complaint) and Carlisle v. NantKwest, Inc., et al., 3:21‑cv‑00304 (filed February 19, 2021) (the Carlisle Complaint). One complaint has been filed in the United States District Court for the Eastern District of New York and was captioned Shenk v. NantKwest, Inc., et al., 1:21‑cv‑00871 (filed February 18, 2021) (the Shenk Complaint, and collectively with the Hargett Complaint, the Franchi Complaint, the Gross Complaint, the Leaman Complaint, the Weiss Complaint, and the Carlisle Complaint, the Merger Actions). The Shenk Complaint was voluntarily dismissed on March 10, 2021. The Franchi Complaint was voluntarily dismissed on May 6, 2021. The Leaman Complaint was voluntarily dismissed on May 7, 2021. The Hargett Complaint and the Gross Complaint were both voluntarily dismissed on May 18, 2021. The Hargett Complaint and the Gross Complaint also brought claims against ImmunityBio, Inc. and Merger Sub. The Merger Actions generally allege that the Definitive Proxy Statement filed with the SEC on February 2, 2021 misrepresents and/or omits certain purportedly material information relating to financial projections, analysis performed by the financial advisor to NantKwest’s Special Committee, alleged past engagements of the Special Committee’s financial advisor and industry consultant, and the terms of the engagement of such consultant. The Merger Actions assert violations of Section 14(a) of the Securities Exchange Act of 1934, as amended (the Exchange Act), and Rule 14a-9 promulgated thereunder against all defendants and violations of Section 20(a) of the Exchange Act against NantKwest’s directors. The Merger Actions seek, among other things, an injunction enjoining the stockholder vote on the Merger and the consummation of the Merger unless and until certain additional information is disclosed to NantKwest’s stockholders, costs of the action, including plaintiffs’ attorneys’ fees and experts’ fees, and other relief the Court may deem just and proper. Neither the stockholder vote on the Merger nor the Merger were enjoined and occurred on March 8 and March 9, 2021, respectively. The company cannot predict the outcome of the Merger Actions. The company believes the Merger Actions are without merit and the company and the individual defendants intend to vigorously defend against the Merger Actions and any subsequently filed similar actions. If additional similar complaints are filed, absent new or significantly different allegations, the company will not necessarily disclose such additional filings.

Securities Litigation

In 2016, a putative securities class action complaint captioned Sudunagunta v. NantKwest, Inc., et al., 16-cv-01947 was filed in federal district court for the Central District of California related to our restatement of certain interim financial statements for the periods ended June 30, 2015 and September 30, 2015. A number of similar putative class actions were filed in federal and state courts in California. The plaintiffs asserted causes of action for alleged violations of Sections 11 and 15 of the Securities Act of 1933 and Sections 10(b) and 20(a) of the Exchange Act, and Rule 10b-5 promulgated thereunder. The plaintiffs sought unspecified damages, costs and attorneys’ fees, and equitable/injunctive or other relief on behalf of putative classes of persons who purchased or acquired our securities during various time periods from July 28, 2015 through March 11, 2016.

In 2018, the district court granted the plaintiffs’ motions for class certification and to strike plaintiffs’ claims under the Exchange Act and Rule 10b-5. The parties informed the Ninth Circuit that they had reached a settlement in principle, moved to stay in appellate proceedings, and notified the district court that they had reached a settlement in principle. The plaintiffs then filed an unopposed motion for preliminary approval of the settlement and notice to class members.

A final approval hearing was held, and the district court granted final approval and entered judgment on May 31, 2019. Under the terms of the settlement, we paid $12.0 million to the plaintiffs as a full and complete settlement of the litigation. The company was responsible for $1.2 million of the settlement amount, which was recognized in selling, general and administrative expense, on the consolidated statement of operations for the year ended December 31, 2018, while the remaining $10.8 million was funded by our insurance carriers under our directors’ and officers’ insurance policy. The settlement amount was deposited into a settlement fund during the year ended December 31, 2019.

Stipulation of Settlement

In 2019, following approval by our Board of Directors, we entered into a settlement agreement (the Stipulation of Settlement) with three stockholders of the company, each of whom had submitted a stockholder demand for the Board of Directors to take action to remedy purported harm to the company resulting from certain alleged wrongful conduct concerning, among other things, disclosures about Dr. Soon-Shiong’s compensation and a related-party lease agreement. The Stipulation of Settlement called for us to adopt certain governance changes, and for the three stockholders to file a stockholder derivative action in the Superior Court of the State of California, County of San Diego, followed by an application for court approval of the Stipulation of Settlement. The court entered an order preliminarily approving the Stipulation of Settlement. Pursuant to the Stipulation of Settlement, we provided stockholders with notice of the settlement and the final settlement hearing.

Under the terms of the Stipulation of Settlement, which received final approval by the court on August 9, 2019, the company paid attorney fees of $0.5 million to the plaintiffs as part of the settlement. Of that amount, we were responsible for half, which was recognized in selling, general and administrative expense, on the consolidated statement of operations for the year ended December 31, 2019, while the other half was funded by our insurance carrier. The settlement amount was deposited into a settlement fund during the year ended December 31, 2019.

Precision Biologics, Inc. Settlement

In 2015, the company invested $50.0 million in cash in Precision in exchange for 41.0 million shares of Precision’s series A preferred stock (representing a 68.5% ownership interest in Precision at the time of the investment). In 2017, a Precision stockholder filed a complaint captioned Feldman v. Soon-Shiong, et al. (individually and derivatively on behalf of Precision), and filed an amended complaint against the company and other defendants asserting claims for breach of contract (including the implied covenant of good faith and fair dealing), tortious interference with contract, breach of the fiduciary duty of loyalty, the appointment of a custodian, fraud in the inducement, and violation of state “Blue Sky” laws. The defendants moved to dismiss the amended complaint. In 2018, the court heard oral arguments and issued an opinion granting in part, and denying in part, defendants’ motion.

In 2019, the parties completed fact discovery other than depositions (and certain document discovery subsequently ordered by the court). The parties agreed in principle to the terms of a settlement and filed a settlement stipulation with the court. A settlement hearing before the court was held, and the court approved the settlement, which was finalized on July 20, 2019. Under the terms of the settlement, the company ended its investment in Precision. As part of the deconsolidation, we withdrew $29.3 million in cash from the investment on our books and transferred $2.5 million to Precision. In addition to $20.2 million of accumulated losses recorded in prior years, which represented the expected losses associated with giving up our preferred stock ownership and absorbing losses arising from the deconsolidation, we recorded a $0.9 million loss associated with the final settlement for the year ended December 31, 2019.

Lease Arrangements

We lease property in multiple facilities across the U.S. and Italy, including facilities located in El Segundo and Culver City, CA that are leased from related parties. Substantially all of our operating lease right-of-use assets and operating lease liabilities relate to facilities leases. See Note 8, Related-Party Agreements, for additional information about our related-party leases.

Our leases generally have initial terms ranging from two to ten years and often include one or more options to renew. These renewal terms can extend the lease term from one to seven years, and are included in the lease term when it is reasonably certain that we will exercise the option.

Information regarding our leases is as follows:


	As of December 31,
	2021		2020
Weighted average remaining lease term	7.8 years		3.9 years
Weighted average discount rate	9.6	%	9.0	%

The components of lease expense consist of the following (in thousands):


	Year Ended December 31,
	2021		2020		2019
Operating lease costs	$	7,977	$	5,668	$	5,795
Variable lease costs	2,862		3,564		2,764
Total lease costs	$	10,839	$	9,232	$	8,559

Cash paid for amounts included in the measurement of lease liabilities is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
Cash paid for operating leases (excluding variable lease costs)	$	9,034	$	7,843	$	7,571

Future minimum lease payments as of December 31, 2021, including $24.1 million related to options to extend lease terms that are reasonably certain of being exercised, are presented in the following table (in thousands). Common area maintenance costs and taxes are not included in these payments.


Years ending December 31:	Operating Leases
2022	$	8,962
2023	8,316
2024	7,768
2025	7,214
2026	5,259
Thereafter	26,098
Total future minimum lease payments	63,617
Less: Interest	20,597
Less: Tenant improvement allowance receivable	2,941
Present value of operating lease liabilities	$	40,079

In February 2021, but effective on January 1, 2021, we entered into a lease agreement with 605 Nash, LLC, a related party, for a facility primarily used for pharmaceutical development and manufacturing purposes. In May 2021, but effective on April 1, 2021, we entered into an amendment to our lease agreement with 605 Nash, LLC. See Note 8, Related-Party Agreements, for further information.

Unconditional Purchase Obligations

Unconditional purchase obligations are defined as an agreement to purchase goods or services that are enforceable and legally binding (non-cancelable, or cancelable only in certain circumstances). In the normal course of business, we enter into unconditional purchase obligation arrangements with a CMO to reserve manufacturing slots in its cGMP manufacturing facility for the manufacture and supply of cGMP batches per FDA and European Medicines Agency (EMA) regulations for commercial use. The total amount of future non-cancelable purchase commitments related to the manufacture of cGMP batches is $3.5 million and $3.5 million for the years ending December 31, 2022 and 2023, respectively.

We estimate our total unconditional purchase obligation commitment (for contracts with terms in excess of one year) as of December 31, 2021, at $2.6 million. Payments by year are estimated as follows: 2022 ($2.1 million) and 2023 ($0.5 million). These commitments relate primarily to hosted software license subscription fees and related implementation costs and our pro-rata share is passed-through to us without any markup under the shared services agreement with NantWorks, as further discussed in Note 8, Related-Party Agreements. The purchase obligation amounts do not represent the entire anticipated purchases in the future, but represent only those items for which we are contractually obligated. The majority of our goods and services are purchased as needed, with no unconditional commitment. For this reason, these amounts do not provide an indication of our expected future cash outflows related to purchases.

Commitments

We did not enter into any significant contracts or material unconditional purchase commitments during the year ended December 31, 2021, other than those disclosed in these consolidated financial statements.

Related-Party Agreements

12 Months Ended

Dec. 31, 2021

Related Party Agreements

Related-Party Agreements

We conduct business with several affiliates under written agreements and informal arrangements. Below is a summary of outstanding balances and a description of significant relationships (in thousands):




	As of December 31,
	2021		2020
Due from related party–NantBio, Inc.	$	1,294	$	1,294
Due from related party–NantOmics LLC	—		591
Due from related parties–Various	39		118
Total due from related parties	$	1,333	$	2,003

Due to related party–NantWorks	$	1,113	$	10,650
Due to related party–Duley Road, LLC	1,380		2,787
Due to related party–NantBio, Inc.	943		943
Due to related party–605 Nash, LLC	—		—
Due to related party–Immuno-Oncology Clinic, Inc.	507		271
Due to related party–Various	—		187
Total due to related parties	$	3,943	$	14,838

Our Executive Chairman, Global Chief Scientific and Medical Officer, and principal stockholder founded and has a controlling interest in NantWorks, which is a collection of companies in the healthcare and technology space. As described below, we have entered into arrangements with NantWorks, and certain affiliates of NantWorks, to facilitate the development of new genetically modified NK cells for our product pipeline. Affiliates of NantWorks are also affiliates of the company due to the common control by and/or common ownership interest of our Executive Chairman and Global Chief Scientific and Medical Officer.

NantWorks

Under the NantWorks shared services agreement executed in November 2015, but effective August 2015, NantWorks, a related party, provides corporate, general and administrative, manufacturing strategy, research and development, regulatory and clinical trial strategy, and other support services. We are charged for the services at cost plus reasonable allocations of employee benefits, facilities and other direct or fairly allocated indirect costs that relate to the employees providing the services. For the years ended December 31, 2021, 2020 and 2019, we recorded $4.4 million, $6.0 million and $6.8 million, respectively, in selling, general and administrative expense, and $0.4 million, $2.0 million and $1.5 million, respectively, of expense reimbursements under this arrangement in research and development expense, on the consolidated statements of operations. These amounts exclude certain general and administrative expenses provided by third-party vendors directly for our benefit, which were reimbursed to NantWorks based on those vendors’ invoiced amounts without markup by NantWorks.

As of December 31, 2021 and 2020, we owed NantWorks a net amount of $1.1 million and $10.7 million, respectively, for all agreements between the two affiliates, which is included in due to related parties, on the consolidated balance sheets. We also recorded $2.2 million and $1.0 million of prepaid expenses for services that have been passed through to the company from NantWorks as of December 31, 2021 and 2020, respectively, which are included in prepaid expenses and other current assets, on the consolidated balance sheets.

In November 2015, we entered into a facility license agreement with NantWorks for approximately 9,500 rentable square feet of office space in Culver City, California, which was converted to a research and development laboratory and a cGMP manufacturing facility. The initial license was effective from May 2015 through December 2020. The base rent for the initial lease term was $47,000 per month, with annual increases of 3% beginning in January 2017. In September 2020, we amended this agreement to extend the term of this lease through December 31, 2021. Commencing January 1, 2021, the base rent increased by 3% to approximately $54,500 per month. Subsequent to December 31, 2021, the lease term will automatically renew on a month-to-month basis, terminable by either party with at least 30 days’ prior written notice to the other party. Lease expense for this facility totaling $0.7 million, $0.6 million and $0.6 million for the years ended December 31, 2021, 2020 and 2019, respectively, was recorded in research and development expense, on the consolidated statements of operations.

Immuno-Oncology Clinic, Inc.

Beginning in 2017, we entered into multiple agreements with Immuno-Oncology Clinic, Inc. (the Clinic) to conduct clinical trials related to certain of our product candidates. The Clinic is a related party as it is owned by an officer of the company and NantWorks manages the administrative operations of the Clinic. Prior to June 30, 2019, one of our officers was an investigator or sub-investigator for all of our trials conducted at the Clinic.

In July 2019, we entered into a new agreement with the Clinic (the Clinic Agreement), which became effective on July 1, 2019. The Clinic Agreement, as amended on March 31, 2020, covers clinical trial and research-related activities on a non-exclusive basis relating to existing clinical trials, commenced prior to July 1, 2019, and prospective clinical trials and research projects. The Clinic Agreement also specifies certain services and related costs that are excluded from the Clinic Agreement. Prior to commencing any work under the Clinic Agreement, the parties have agreed to execute written work orders setting forth the terms and conditions related to specific services to be performed, including financial terms. For clinical trials that commenced prior to July 1, 2019, excluding certain NantCell trials not covered by the agreement, fees incurred for services performed after July 1, 2019 are covered under the Clinic Agreement and applied towards the below-mentioned prepayments. The Clinic Agreement allows for automatic renewal and additional extensions beyond the initial one-year term.

In consideration of the services to be performed under the Clinic Agreement, as amended on March 31, 2020, we agreed to make payments of up to $7.5 million to the Clinic, of which $3.8 million and $1.9 million were paid in July 2019 and October 2019, respectively. As amended, a conditional payment of $1.9 million shall be due and payable at such time, if any, that the payments made in July 2019 and October 2019 have been earned by the Clinic through the performance of services. On a quarterly basis, our prepayment is increased by a nominal interest credit computed in accordance with terms specified in the Clinic Agreement.

The Clinic may terminate this agreement upon each anniversary date upon 60 days prior written notice and reimbursement in full to us of any outstanding unearned balance of the prepayments, provided that any such termination by the Clinic will not apply with respect to any work orders still in effect at the time of such termination.

We executed a clinical trial work order under the Clinic Agreement for an open-label, Phase 1 study of PD‑L1 t‑haNK™ for infusion in subjects with locally advanced or metastatic solid cancers. In July 2020, but effective on June 22, 2020, we and NantCell executed a clinical trial work order under our existing master agreement with the Clinic for an open-label, randomized, comparative Phase 2 study of our proprietary IL‑15 superagonist (Anktiva) and aldoxorubicin hydrochloride (aldoxorubicin) and our PD‑L1 t‑haNK with standard-of-care chemotherapy versus standard-of-care chemotherapy for patients with locally advanced or metastatic pancreatic cancer treated as first-line, second-line, or third-line or greater, in three separate cohorts, respectively.

During the year ended December 31, 2021, ImmunityBio executed multiple work orders under an existing master agreement with the Clinic. Under these work orders, the parties agreed that the Clinic would serve as a site for the following multi-site clinical trials:

•A Phase 1B open-label study of the safety, reactogenicity, and immunogenicity of prophylactic vaccination with second-generation E1/E2B/E3-deleted adenoviral-COVID-19 in normal healthy volunteers;

•A Phase 1B open-label study of the safety, reactogenicity, and immunogenicity of subcutaneously and orally administered prophylactic vaccination with second-generation E1/E2B/E3-deleted adenoviral-COVID-19 in normal healthy volunteers;

•A Phase 1 study of the safety, reactogenicity, and immunogenicity of subcutaneously- and orally-administered supplemental spike & nucleocapsid-targeted COVID‑19 vaccine to enhance T cell-based immunogenicity in participants who have already received a vaccine authorized for emergency use;

•A Phase 1 study of the safety, reactogenicity, and immunogenicity of a supplemental spike & nucleocapsid-targeted COVID‑19 vaccine to enhance T cell-based immunogenicity in participants who have already received a vaccine authorized for emergency use; and

•A Phase 1 open-label study of M‑ceNK cells in subjects with locally advanced or metastatic solid tumors.

In the second quarter of 2021, based on a review of our then updated clinical trial programs post-Merger, we updated our estimates of the investigator fees for the clinical trials that were underway or planned at the Clinic. As certain programs costs are excluded from and certain services are subject to credit adjustments under the Clinic agreements, we determined the expected future fees for services to be performed were less than the carrying value of the prepaid asset on the consolidated balance sheets. As a result, we partially wrote down the value of our prepayments under the Clinic agreements and recorded approximately $1.9 million in research and development expense, on the consolidated statement of operations for the three months ended June 30, 2021. In November 2021, we completed a review of alternative structures that could support our more complex clinical trial requirements and made a decision to explore a potential transition of clinical trials at the Clinic to a new structure (including contracting with a new, non-affiliated professional corporation) to be determined and agreed upon by all parties and currently planned for the first half of 2022. Based on this decision to explore a potential transition, we determined that it was more likely than not that the previously recorded prepaid asset would not result in the collection of fees for services performed by the Clinic as contemplated in the original agreements. As a result, we wrote down the remaining value of our prepaid asset and recorded approximately $2.5 million in research and development expense, on the consolidated statement of operations for the three months ended December 31, 2021.

For the years ended December 31, 2021, 2020 and 2019, we incurred $1.6 million, $0.9 million and $1.1 million in research and development expense, on the consolidated statements of operations related to the Clinic Agreement. As of December 31, 2021 and 2020, we owed the Clinic $0.5 million and $0.3 million, respectively, for services excluded from the Clinic Agreement. As of December 31, 2020, we had prepaid balances related to the Clinic Agreement of $4.7 million.

Brink Biologics, Inc.

In 2015, we entered into an agreement with Brink Biologics, Inc. (Brink) whereby we granted to Brink worldwide exclusive licenses to the use of certain cell lines and intellectual property for non-clinical laboratory testing. Brink is a related party as our Executive Chairman, Global Chief Scientific and Medical Officer and our principal stockholder, and our Chief Corporate Affairs Officer and member of our board of directors, collectively own more than 50% of Brink’s outstanding shares. We recognized revenue of $0.4 million for the year ended December 31, 2021 related to this license.

NantBio, Inc.

In March 2016, NantBio and the NCI entered into a CRADA. The initial five-year agreement covered NantBio and its affiliates, including us. Under the agreement, the parties collaborated on the preclinical and clinical development of proprietary recombinant NK cells and mAbs in monotherapy and combination immunotherapies. In each of the contractual years under the agreement, we paid $0.6 million to the NCI for services under the agreement. We recognized expenses related to this agreement ratably over a 12-month period for each funding year. This CRADA expired in March 2021. In November 2021, we entered into a third amendment to the 2015 NCI CRADA, which was effective as of March 16, 2021, and transferred the research plan from this expired CRADA into the research plan of the amended 2015 NCI CRADA. We made a payment of $0.7 million and recorded $0.5 million in research and development expense, on the consolidated statements of operations related to the third amendment for the year ended December 31, 2021. See Note 6, Collaboration and License Agreements—National Cancer Institute, for further information.

In August 2018, we entered into a supply agreement with NantCancerStemCell, LLC (NCSC), a 60% owned subsidiary of NantBio (with the other 40% owned by Sorrento). Under this agreement, we agreed to supply VivaBioCell’s proprietary GMP-in-a-Box bioreactors and related consumables, made according to specifications mutually agreed to with both companies. The agreement has an initial term of five years and renews automatically for successive one-year terms unless terminated by either party in the event of material default upon prior written notice of such default and the failure of the defaulting party to remedy the default within 30 days of the delivery of such notice, or upon 90 days’ prior written notice by NCSC. We recognized revenue of $0.3 million for the year ended December 31, 2021. We recorded $0.1 million and $0.3 million of deferred revenue for bioreactors that were delivered but not installed as of December 31, 2021 and 2020, respectively. As of December 31, 2021 and 2020, we recorded $0.9 million in due to related parties, on the consolidated balance sheets related to this agreement.

In 2018, we entered into a shared service agreement pursuant to which we are charged for services at cost, without mark-up or profit by NantBio, but including reasonable allocations of employee benefits that relate to the employees providing the services. In April 2019, we agreed with NantBio to transfer certain NantBio employees and associated research and development projects, comprising the majority of NantBio’s business, to the company. After the transfer, we settled certain employee bonuses and benefits that were accrued by NantBio for 2018. As of December 31, 2021 and 2020, we recorded a net receivable from NantBio of $1.3 million, which included $1.0 million for employee bonuses and $0.3 million for vendor costs we paid on behalf of NantBio.

NantOmics, LLC

In 2019, we made a strategic decision and transferred certain employees from NantOmics, a related party that is controlled by our Executive Chairman and Global Chief Scientific and Medical Officer, to the company. After the transfer, we settled certain employee bonuses and benefits that were accrued by NantOmics for the year ended December 31, 2020. We recorded no receivable and a $0.6 million receivable from NantOmics as of December 31, 2021 and 2020, respectively.

605 Doug St, LLC

In September 2016, we entered into a lease agreement with 605 Doug St, LLC, an entity owned by our Executive Chairman and Global Chief Scientific and Medical Officer, for approximately 24,250 rentable square feet in El Segundo, California, which has been converted to a research and development laboratory and a cGMP manufacturing facility. The lease runs from July 2016 through July 2023. We have the option to extend the lease for one additional three-year term through July 2026. We have included the first option to extend the lease term for three years as part of the initial lease term as it is reasonably certain that we will exercise the option, which implies lease expiration in July 2026. The base rent is approximately $72,385 per month, with annual increases of 3% that began in July 2017. Lease expense for this facility totaling $0.9 million for the years ended December 31, 2021, 2020 and 2019, respectively, was recorded in research and development expense, on the consolidated statements of operations.

Duley Road, LLC

In February 2017, Altor BioScience Corporation (succeeded by our wholly-owned subsidiary Altor BioScience, LLC), through its wholly-owned subsidiary, entered into a lease agreement with Duley Road, a related party that is indirectly controlled by our Executive Chairman and Global Chief Scientific and Medical Officer, for approximately 12,000 rentable square feet of office and cGMP manufacturing facility space in El Segundo, California. The lease term is from February 2017 through October 2024. We have the option to extend the initial term for two consecutive five-year periods through October 2034. The base rent is approximately $40,700 per month, with annual increases of 3% that began in November 2018. As of December 31, 2021 and 2020, we recorded rent payable to Duley Road of $0.2 million and $1.3 million, respectively. For the years ended December 31, 2021 and 2020, we recorded rent expense of $0.6 million and $0.5 million, respectively, which is reflected in research and development expense, on the consolidated statements of operations.

Effective in January 2019, we entered into two lease agreements with Duley Road for a second building located in El Segundo, California. The first lease is for the first floor of the building with approximately 5,650 rentable square feet. The lease has a seven-year term commencing in September 2019. The second lease is for the second floor of the building with approximately 6,488 rentable square feet. The lease has a seven-year term commencing in July 2019. Both floors of the building are used for research and development and office space. We have options to extend the initial terms of both leases for two consecutive five-year periods through 2036. The base rent for the two leases is approximately $35,800 per month that increases at a rate of 3% per year.

As of December 31, 2021 and 2020, we recorded $0.9 million and $0.9 million of leasehold improvement payables, respectively, and $0.3 million and $0.6 million of lease-related payables to Duley Road, which were included in due to related parties, on the consolidated balance sheets. For the years ended December 31, 2021 and 2020, we recorded $0.4 million and $0.3 million of rent expense for the two leases, respectively, which was included in research and development expense, on the consolidated statements of operations.

605 Nash, LLC

In February 2021, but effective on January 1, 2021, we entered into a lease agreement with 605 Nash, a related party, whereby we leased approximately 6,883 rentable square feet (the Initial Premises) in a two story mixed use building containing approximately 64,643 rentable square feet on 605-607 Nash Street in El Segundo, California. This facility is used primarily for pharmaceutical development and manufacturing purposes. The lease term commenced in January 2021 and expires in December 2027, and includes an option to extend the lease for one three-year term through December 2030. The base rent is approximately $20,300 per month with an annual increase of 3% on January 1 of each year during the lease term. In addition, under the agreement, we are required to pay our share of estimated property taxes and operating expenses. We have included the first option to extend the lease term for three years as part of the initial lease term as it is reasonably certain that we will exercise the option. We will receive a rent abatement for the first seven months, and a tenant improvement incentive of $0.3 million from the landlord for costs and expenses associated with the construction of tenant improvements for the Initial Premises. During the year ended December 31, 2021, we recorded rent expense of $0.2 million, which is reflected in research and development expense, on the consolidated statement of operations.

In May 2021, but effective on April 1, 2021, we entered into an amendment to our Initial Premises lease with 605 Nash. The amendment expanded the leased square feet by approximately 57,760 rentable square feet (the Expansion Premises). The lease term of the Expansion Premises commenced in April 2021 and expires in March 2028, whereby the company has the option to extend the initial term for three years. Per the terms of the amendment, the term of the Initial Premises lease was extended for an additional three months and now expires in March 2031. Base rent for the Expansion Premises is approximately $170,400 per month with annual increases of 3% on April 1 of each year. We are responsible for the build out of the facility space and associated costs. The amended lease provides for a rent abatement for the first seven months, and for a tenant improvement allowance of approximately $2.6 million for costs and expenses related to improvements made by us to the Expansion Premises. During the year ended December 31, 2021, we incurred $1.5 million of rent expense related to the Expansion Premises lease agreement.

557 Doug St, LLC

On September 27, 2021, we entered into a Membership Interest Purchase Agreement with Nant Capital (the Purchase Agreement). Nant Capital is a related party controlled by Dr. Soon-Shiong. The Purchase Agreement transferred all outstanding membership interests in 557 Doug St, LLC from the company to Nant Capital. The only asset owned by 557 Doug St, LLC is the improved property located at 557 South Douglas Street, El Segundo, California with a building area of approximately 36,434 rentable square feet (the Douglas Property).

The purchase price under the Purchase Agreement was $22.0 million, and after the offset prorated property taxes of $0.1 million, the net proceeds from the sale were $21.9 million. An independent appraisal of the Douglas Property (the Appraisal) assigned the Douglas Property a value of $22.0 million. The net carrying value of the property was $20.5 million as of the closing date. We accounted for the transfer as a sale of an asset to an entity under common control, recorded the transfer at book value and recognized the excess of net consideration over carrying book value of $1.4 million as a capital contribution received from Nant Capital in additional paid-in capital, on the consolidated statement of stockholders’ deficit for the year ended December 31, 2021.

In September 2021, we entered into a lease agreement with Nant Capital under which we leased back 557 South Douglas Street for an initial lease term of seven years, which commenced on September 27, 2021. The monthly base rent under the lease is approximately $81,976 per month with an annual increase of 3% on October 1 of each year beginning in 2022 during the initial term and, if applicable, during the option term. For the first two years under the lease we will not be charged rent; we will begin paying rent on October 1, 2023 at the current monthly base rent. We prepaid the first month rent and security deposit totaling $0.2 million upon the execution of the lease. We have an option to extend the lease for two additional seven-year periods when the prior term expires. We have included the first option to extend the lease term for seven years as part of the initial lease term as it is reasonably certain that we will exercise the option, which implies lease expiration on September 30, 2035. The lease is classified as an operating lease. As of December 31, 2021, we recorded $0.3 million of rent expense for the lease, which was included in research and development expense, on the consolidated statements of operations.

420 Nash, LLC

On September 27, 2021, we entered into a lease agreement with 420 Nash, LLC, a related party, whereby we leased an approximately 19,125 rentable square foot property located at 420 Nash Street, El Segundo, California, to be used primarily for the warehousing and storage of drug manufacturing supplies, products and equipment and ancillary office space.

Under the terms of the lease agreement, the lease term began on October 1, 2021 and expires on September 30, 2026. The base rent is approximately $38,250 per month with an annual increase of 3% on October 1 of each year beginning in 2022 during the initial term. The company is responsible for the payment of real property taxes, repairs and maintenance, improvements, insurance and operating expenses during the term of the lease. We will receive a rent abatement for the first month of the lease, and a one-time improvement allowance of $15,000 from the landlord that will be credited against base rent obligations for the second month of the lease.

The company has options to extend the lease term for two additional consecutive periods of five years each. At the beginning of each option term, the initial monthly base rent will be adjusted to market rent (as defined in the lease agreement) with an annual increase of 3% during the option term. We have included the first option to extend the lease term for five years as part of the initial term of the lease as it is reasonably certain that we will exercise the option, which implies lease expiration in September 2031. As of December 31, 2021, we recorded $0.1 million of rent expense for the lease, which was included in research and development expense, on the consolidated statement of operations.

Related-Party Notes Payable

Our related-party notes payable consist of the following (in thousands):


						Total Notes and Interest Payable as of December 31,
Related-Party Notes Payable	Note Year	Outstanding Advances		Interest Rate		2021			2020

Nant Capital (1)	2021	$	300,000	SOFR + 5.4%		$	299,236	(1)	$	—
Nant Capital (2)	2015	55,226		5.0	%	61,367		(3)	58,482		(3)
Nant Capital (2)	2020	50,000		6.0	%	53,810		(4)	50,764		(4)
Nant Capital (5)	2021	40,000		6.0	%	40,000		(5)	—
NantMobile (2)	2019	55,000		3.0	%	58,359		(6)	56,660		(6)
NantWorks (2)	2017	43,418		5.0	%	54,067		(7)	51,546		(7)
NCSC (2)	2018	33,000		5.0	%	38,746		(8)	36,901		(8)
Total related-party notes payable		$	576,644			$	605,585		$	254,353

_______________


(1)			The outstanding advance is due and payable on December 17, 2022. This loan bears interest at Term SOFR + 5.4%, which is compounded annually and payable quarterly commencing on March 17, 2022. As of December 31, 2021, the interest rate on this loan was 5.47%. Accrued and unpaid interest on this note totaled $0.7 million as of December 31, 2021. In the event of a default on the loan (as defined in the promissory note), including if we do not repay the loan at maturity, the company has the right, at its sole option, to convert the outstanding principal amount and accrued and unpaid interest due under this note into fully paid and non-assessable shares of the company’s common stock at a price per share equal to $5.67. Debt issuance cost of $1.5 million paid to the lender in December 31, 2021 was recorded as a reduction of the principal amount of the note.

(2)			All outstanding advances and accrued and unpaid interest is due and payable on September 30, 2025. Interest on related-party notes payable is compounded annually. We may prepay the outstanding principal at any time without premium, penalty or the prior consent of the issuer. All outstanding amounts under the notes become due and payable upon certain bankruptcy and insolvency-related events. There are no equity or equity-linked convertible rights related to these promissory notes.

(3)			Accrued and unpaid interest on this note totaled $6.1 million and $3.3 million as of December 31, 2021 and 2020, respectively.

(4)			Accrued and unpaid interest on this note totaled $3.8 million and $0.8 million as of December 31, 2021 and 2020, respectively.

(5)			The outstanding principal is due and payable on September 30, 2025. Interest on this related-party note is compounded annually and payable quarterly commencing on June 30, 2021. We paid $2.0 million in interest on this loan during the year ended December 31, 2021. All outstanding amounts under the note become due and payable upon certain bankruptcy and insolvency-related events. There are no equity or equity-linked convertible rights related to this promissory note.

(6)			Accrued and unpaid interest on this note totaled $3.4 million and $1.7 million as of December 31, 2021 and 2020, respectively.

(7)			Accrued and unpaid interest on this note totaled $10.6 million and $8.1 million as of December 31, 2021 and 2020, respectively.

(8)			Accrued and unpaid interest on this note totaled $5.7 million and $3.9 million as of December 31, 2021 and 2020, respectively.

The following table summarizes our estimated future contractual obligations for related-party notes payable as of December 31, 2021 (in thousands):


	Principal Payments		Interest Payments (1)			Total
2022	$	300,000	$	18,808	(2)	$	318,808
2023	—		2,400			2,400
2024	—		2,407			2,407
2025	276,644		85,823		(3)	362,467
Total principal and estimated interest due on related-party notes	$	576,644	$	109,438		$	686,082

_______________


(1)			Interest payments on our fixed-rate debt are calculated based on contractual interest rates and scheduled maturity dates. Interest payments on our variable-rate debt are calculated based on schedule maturity dates and the Term SOFR rate plus the contractual spread per the loan agreement. The rate on this debt as of December 31, 2021 was 5.47%.

(2)			Interest shown includes $0.7 million of accrued and unpaid interest as of December 31, 2021 related to the $300.0 million variable-rate loan. Interest on our $300.0 million variable-rate loan and our $40.0 million fixed-rate loan are payable on a monthly and quarterly basis, respectively.

(3)			Interest shown includes $29.7 million of accrued and unpaid interest of December 31, 2021. Interest on these notes is payable at maturity on September 30, 2025.

Stockholders’ Deficit	12 Months Ended
Stockholders’ Deficit	Dec. 31, 2021
Equity [Abstract]
Stockholders’ Deficit	Stockholders’ Deficit Stock Authorized for Issuance As of December 31, 2021, the company was authorized to issue up to 500,000,000 shares of its common stock, par value $0.0001 per share, and 20,000,000 shares of our preferred stock, par value $0.0001 per share. As of December 31, 2021, there were 397,830,044 shares of our common stock outstanding (excluding 163,800 shares held by a majority owned subsidiary of the company that are treated as treasury shares for accounting purposes). Effective February 1, 2022, ImmunityBio amended and restated its Amended and Restated Certificate of Incorporation to increase the number of shares of common stock that the company is authorized to issue from 500,000,000 shares to 900,000,000 shares. The number of shares of preferred stock that the company is authorized to issue remains unchanged at 20,000,000 shares. See Note 13, Subsequent Events. Common Stock Issued in Connection with the Merger Under the terms of the Merger Agreement, at the Effective Time of the Merger, each share of NantCell common stock, par value $0.001 per share, issued and outstanding immediately prior to the Effective Time, subject to certain exceptions as set forth in the Merger Agreement, was converted automatically into a right to receive 0.8190 newly issued shares of common stock, par value $0.0001 per share, resulting in the issuance of approximately 273.7 million shares of Company Common Stock. From and after the Effective Time, all of such NantCell shares ceased to be outstanding, were canceled and ceased to exist. At the Effective Time, each share of our common stock issued and outstanding immediately prior to the Effective Time, remained an issued and outstanding share of the combined company. Since the Merger was accounted for as a transaction between entities under common control, the outstanding shares presented on the consolidated financial statements assume that NantCell outstanding common stock was converted into shares of Company Common Stock for all periods presented, and in connection with the conversion, those shares of common stock were recorded at the company’s par value of $0.0001 per share. Stock Repurchases 2015 Share Repurchase Program In 2015, the Board of Directors approved the 2015 Share Repurchase Program, which allows our CEO or chief financial officer (CFO), to repurchase on behalf of the company, from time to time in the open market or in privately negotiated transactions, up to $50.0 million of our outstanding shares of common stock, exclusive of any commissions, markups or expenses. The timing and amounts of any purchases were and will continue to be based on market conditions and other factors, including price, regulatory requirements and other corporate considerations. The 2015 Share Repurchase Program does not require the purchase of any minimum number of shares and may be suspended, modified, or discontinued at any time without prior notice. We have financed, and expect to continue to finance, the purchases with existing cash balances. Shares repurchased under this program are formally retired through approval of the Board of Directors upon repurchase. No shares of our common stock were repurchased during the years ended December 31, 2021 and 2020 under the program. During the year ended December 31, 2019, we repurchased 473,586 shares at a cost of $0.5 million. Since the plan’s inception, we have repurchased a total of 6,403,489 shares at a total cost of $31.7 million. As of December 31, 2021, $18.3 million remained authorized for repurchase under the program. Other Repurchase During the year ended December 31, 2019, we entered into a stock transfer agreement with a stockholder and purchased 204,750 shares of our common stock at a price of $9.77 per share for an aggregate purchase price of $2.0 million in cash. All shares repurchased in this transaction were retired and reduced the number of shares issued and outstanding. Open Market Sale Agreement On April 30, 2021, we entered into an Open Market Sale Agreement (the Sale Agreement) with respect to an ATM offering program under which we may offer and sell, from time to time at our sole discretion, shares of our common stock, having an aggregate offering price of up to $500.0 million through our sales agent. We pay our sales agent a commission of up to 3.0% of the gross sales proceeds of any shares of our common stock sold through them under the Sale Agreement, and also have provided them with customary indemnification and contribution rights. During the year ended December 31, 2021, we received net proceeds totaling $164.5 million from the issuance of 13,295,817 shares under the ATM, which we expect to use for general corporate purposes, including to progress our clinical development programs, fund other research and development activities, make capital expenditures and fund working capital. We may also use a portion of the net proceeds to license intellectual property or to make acquisitions or investments. As of December 31, 2021, we had $330.8 million available for future stock issuances under the ATM. We are not obligated to sell any shares and may at any time suspend solicitation and offers under the Sale Agreement. The Sale Agreement may be terminated by us at any time given written notice to the sales agent for any reason or by the sales agent at any time by giving written notice to us for any reason or immediately under certain circumstances, and shall automatically terminate upon the issuance and sale of all of the shares. Other Sales of Common Stock During the year ended December 31, 2020, the company closed an underwritten public offering of an aggregate of 8,521,500 shares of common stock, which included 4,811,500 shares issued to the public at a price of $9.50 per share (including 1,111,500 shares sold to the public upon full exercise of the underwriters’ option to purchase additional shares at a public offering price of $9.50 per share), less underwriting discounts and commissions, and 3,710,000 shares issued to Dr. Soon-Shiong, our Executive Chairman and Global Chief Scientific and Medical Officer, at a price of $12.12 per share, less underwriting discounts and commissions. All of the shares were offered by the company. Including the underwriters’ option exercise, the aggregate gross proceeds from the offering were $90.7 million, before deducting underwriting discounts, commissions and other offering costs of $4.4 million. During the year ended December 31, 2019, the company sold 2,047,500 shares of common stock at a price of $14.66 per share to a private party and received net proceeds totaling $30.0 million.

- Definition

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

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+ Details

Stock-Based Compensation

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Stock-Based Compensation

2015 Equity Incentive Plan

In 2015, the Board of Directors adopted, and our stockholders approved, the 2015 Plan. The 2015 Plan, as amended, permits the grant of incentive stock options to the company’s employees, and the grant of non-statutory stock options, restricted stock, RSUs, stock appreciation rights, performance units and performance shares to the company’s employees, directors and consultants. In addition, the number of shares reserved for future grant under the 2015 Plan include shares subject to stock options granted under the 2014 Plan that expire or terminate without having been exercised in full and shares issued pursuant to awards granted under the 2014 Plan that are forfeited to or repurchased by us (provided that the maximum number of shares that may be added to the 2015 Plan pursuant to this provision is approximately 503,493 shares as of December 31, 2021). Pursuant to the Merger, we assumed 7,121,110 RSUs (adjusted for the Exchange Ratio of 0.8190) issued under the 2015 NC Plan.

As of December 31, 2021, the 2015 Plan is the only equity plan available for grant of equity awards to employees, directors and consultants of the company. As of December 31, 2021, a total of approximately 5.0 million shares were available for future grants under the 2015 Plan.

Stock-Based Compensation

The following table presents stock-based compensation included on the consolidated statements of operations (in thousands):


	Year Ended December 31,
	2021		2020		2019
Stock-based compensation expense:
Stock options	$	11,623	$	1,426	$	2,053
RSUs	45,558		761		1,368
	$	57,181	$	2,187	$	3,421
Stock-based compensation expense in operating expenses:
Research and development	$	18,819	$	261	$	1,288
Selling, general and administrative	38,362		1,926		2,133
	$	57,181	$	2,187	$	3,421

On March 18, 2021, the Board of Directors approved to modify certain non-qualified stock options that were assumed in the Merger and otherwise would have expired during a period when the grantees were legally restricted from exercising these awards. The expiration date of these options was extended to thirty (30) days following the effective date of Post-Effective Amendment No. 1 on Form S-3 to our Form S-4 Registration Statement. We recorded an incremental stock-based compensation expense of approximately $2.7 million for this stock option modification.

On March 29, 2021, in connection with the resignation of two former independent directors, the Board of Directors approved the acceleration of vesting of 83,333 shares of unvested stock options of the former directors on the date of their respective resignations. The modified options are exercisable for ninety (90) days after the date of the modification. We recorded an incremental stock-based compensation expense of approximately $2.3 million for this stock option modification.

The stock option modifications were measured as the excess of the fair value of the modified awards over the fair value of the original awards immediately before the modifications. The incremental stock-based compensation was recorded in selling, general and administrative expense, on the consolidated statement of operations for the year ended December 31, 2021.

Stock Options

The following table summarizes stock option activity and related information for the year ended December 31, 2021:


	Number of Options	Weighted- Average Exercise Price		Aggregate Intrinsic Value (in thousands)		Weighted- Average Remaining Contractual Life (in years)
Outstanding at December 31, 2020	4,996,284	$	9.96	$	29,746	4.7
Granted	1,069,940	$	21.38
Exercised	(1,817,300)	$	3.95
Expired/forfeited	(123,994)	$	10.10
Outstanding at December 31, 2021	4,124,930	$	15.62	$	4,178	5.3
Vested and exercisable at December 31, 2021	3,038,322	$	13.89	$	3,978	3.9

On February 5, 2021, the Compensation Committee of the Board of Directors granted Richard Adcock, our chief executive officer, a stock option award (the Option Grant) to purchase 750,000 shares of our common stock pursuant to our 2015 Plan. The Option Grant has an exercise price of $23.72 per share, the closing price as reported on the Nasdaq on the date of grant. In addition, the Option Grant shall vest according to the following vesting schedule: one-third of the Option Grant (i.e., 250,000 options) shall vest in equal installments on each of the first, second, and third anniversaries of the date of grant, such that all shares shall be fully vested on the third anniversary of the date of grant, subject to Mr. Adcock remaining in continuous service as defined in the 2015 Plan through the applicable vesting dates. This grant of equity awards to Mr. Adcock was made in connection with his appointment as chief executive officer of the company, which was effective as of October 26, 2020, and was modified from the recommended equity grant described in Mr. Adcock’s offer of employment as of that date.

On May 3, 2021, the Compensation Committee of the Board of Directors granted each of our newly-appointed independent directors a non-qualified stock option award to purchase 21,873 shares of our common stock pursuant to the 2015 Plan at an exercise price of $17.24 per share, the closing price as reported on the Nasdaq on the date of grant. The shares subject to the award will vest in three (3) equal installments on each of the first, second and third anniversary date of their appointment to the Board of Directors, such that the award will be fully vested on the third anniversary date in 2024, subject to the director continuing to be a service provider as defined in the 2015 Plan through the applicable vesting dates.

On June 10, 2021, the Compensation Committee of the Board of Directors granted our Chairman and each of the independent members of our Board of Directors a non-qualified stock option award to purchase 26,064 shares of our common stock pursuant to the 2015 Plan at an exercise price of $14.91 per share, the closing price as reported on the Nasdaq on the date of grant. The shares subject to the award will vest 100% on the earlier to occur of June 10, 2022 or the date immediately preceding the 2022 annual meeting of stockholders, subject to the recipient continuing to be a service provider as defined in the 2015 Plan through the applicable vesting date. These grants were made in connection with the re-election of our Executive Chairman (who then later also became our Global Chief Scientific and Medical Officer), and independent directors to the Board of Directors at the 2021 Annual Meeting of Stockholders.

As of December 31, 2021, the unrecognized compensation cost related to outstanding stock options was $11.8 million, which is expected to be recognized over a remaining weighted-average period of 2.0 years.

The total intrinsic value of stock options exercised during the year ended December 31, 2021 was $21.3 million. Cash proceeds received from stock option exercises during the year ended December 31, 2021 was $5.4 million.

As of December 31, 2020, a total of 4,345,497 vested and exercisable shares were outstanding.

The fair value of stock options issued was estimated at the date of grant using the Black-Scholes option pricing model with the following weighted-average assumptions:


	Year Ended December 31,
	2021			2020			2019
Expected life (in years)	5.9 years			5.5 years			N/A
Risk-free interest rate	0.7		%	0.4		%	N/A
Volatility factor	101.0		%	96.8		%	N/A
Dividend yield	0.0		%	0.0		%	N/A
Weighted-average grant date fair value	$	16.80		$	4.64		N/A

The expected term was estimated using the average of the contractual term and the weighted-average vesting term of the options. The risk-free interest rate was based on the U.S. Treasury’s rates for U.S. Treasury zero-coupon bonds with maturities similar to those of the expected term of the award being valued. The expected volatility was estimated based on the historical volatility of our common stock. The assumed dividend yield was based on our expectation of not paying dividends for the foreseeable future.

Restricted Stock Units

The following table summarizes RSU activity during the year ended December 31, 2021:


	Number of Units	Weighted- Average Grant Date Fair Value
Nonvested balance at December 31, 2020	466,842	$	2.52
Granted	8,665,942	$	23.27
Vested	(873,058)	$	19.61
Forfeited/canceled	(1,743,837)	$	24.77
Nonvested balance at December 31, 2021	6,515,889	$	21.88

As of December 31, 2021, there was $112.1 million of unrecognized stock-based compensation expense related to RSUs that is expected to be recognized over a weighted-average period of 3.5 years. The total intrinsic value of RSUs vested during the year ended December 31, 2021 was $12.2 million.

We may grant RSUs to both employees and directors of the company and to employees of related parties that provide shared services to the company under our shared services agreement with NantWorks as discussed in Note 8, Related-Party Agreements. The grant date fair value of an RSU equals the closing price of our common stock on the date of grant.

On February 5, 2021, the Compensation Committee of the Board of Directors granted Mr. Adcock two awards totaling 400,000 RSUs (each an RSU Award and collectively, the RSU Awards) of our common stock pursuant to the 2015 Plan. The RSU Awards are comprised of two separate awards, one settled by issuing 150,000 shares of our common stock and the other to be settled by issuing 250,000 shares of our common stock upon vesting. The first RSU Award vested immediately on the date of grant with the company retaining shares equal in value to the company’s tax withholding obligations. The second RSU Award will vest according to the following schedule: one-third (i.e., 83,333) of the shares subject to the RSU Award shall vest in equal annual installments on each of the first, second and third anniversaries of the date of grant, such that all shares shall be fully vested on the third anniversary of the date of grant, subject to Mr. Adcock remaining in continuous service as defined in the 2015 Plan through the applicable vesting dates. This grant of equity awards to Mr. Adcock was made in connection with his appointment as chief executive officer of the company, which was effective as of October 26, 2020, and was modified from the recommended equity grant described in Mr. Adcock’s offer of employment as of that date.

On March 4, 2021, prior to the Merger, NantCell awarded 7,121,110 RSUs (adjusted for the Exchange Ratio of 0.8190) to certain employees, consultants and/or service providers of NantCell and its affiliates, pursuant to the NC 2015 Plan. These RSU awards were subject to a performance condition in connection with a “Liquidity Event”, defined as either (i) NantCell’s registration of shares for issuance on a securities offering or (ii) the closing of a corporate transaction. In addition, the vesting of certain performance-based RSU grants accelerates upon obtaining approval by the FDA of a BLA or equivalent application for approval of Anktiva for use in the treatment of non-muscle-invasive bladder cancer. These performance-based RSUs are also subject to service conditions and are scheduled to cliff vest on the last date of each tranche as defined by the individual grant agreements. On March 9, 2021, we completed the Merger with NantCell, and the performance condition related to the Liquidity Event was met.

The fair value of the RSUs was estimated based on a third-party valuation as of the grant date of March 4, 2021 and was derived primarily from the estimated probabilities of the Merger close on March 9, 2021 and the other exit assumptions. Once the liquidity event related performance condition was met as of March 9, 2021 due to the Merger, compensation expense for these RSUs began to be recognized on a graded vesting attribution approach over the requisite service period for each participant, which ranges from six-month to seventy (70)-month vesting periods. During the year ended December 31, 2021, we recorded approximately $40.5 million of stock-based compensation expense related to these awards, of which approximately $18.9 million was recorded in research and development expense and approximately $21.6 million was recorded in selling, general and administrative expense, on the consolidated statement of operations.

The RSUs awarded to employees and consultants of affiliated companies were accounted for as stock-based compensation in accordance with ASU 2018-07, Compensation—Stock Compensation (Topic 718), as the compensation was in exchange for continued support or services expected to be provided to the company over the vesting periods under the NantWorks shared services agreement discussed in Note 8, Related-Party Agreements. We have evaluated the associated benefit of these awards to the affiliated companies under common control and determined that the benefit is limited to the retention of their employees. We estimated such benefit at the grant date fair value of $4.0 million and recorded $0.9 million of deemed dividends for the year ended December 31, 2021 in additional paid-in capital, on the consolidated balance sheets, with a corresponding credit to stock-based compensation expense.

Warrants

In connection with the Merger, warrants issued to NantWorks, a related party, in connection with NantCell’s acquisition of Altor were assumed by the company. After applying the Exchange Ratio at the Effective Time of the Merger, a total of 1,638,000 warrants with an exercise price of $3.24 per share were outstanding as of December 31, 2021. The fair value of $18.0 million assigned to the warrants will be recognized in equity upon achievement of a performance-based vesting condition pertaining to building manufacturing capacity to support supply requirements for one of our product candidates.

Income Taxes

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Income Taxes

We are subject to U.S. federal income tax, as well as income tax in Italy, South Korea, California and other states. From inception through December 31, 2021, we have not been required to pay U.S. federal and state income taxes because of current and accumulated net operating losses. Our federal returns for tax years 2018 through 2020 remain open to examination, and our state returns remain subject to examination for tax years 2017 through 2020. The Italian and South Korea returns for tax years 2016 through 2020 remain open to examination. Carryforward attributes that were generated in years where the statute of limitations is closed may still be adjusted upon examination by the Internal Revenue Service (IRS) or other respective tax authorities. No income tax returns are currently under examination by taxing authorities. There are no cumulative earnings in our Italian and South Korean subsidiaries as of December 31, 2021 that would be subject to U.S. income tax or foreign withholding tax. We plan to indefinitely reinvest any future earnings of our foreign subsidiaries.

On March 9, 2021, the company completed the Merger with NantCell. The Merger is accounted for as a transaction between entities under common control, and is considered a nontaxable transaction for U.S. income tax purposes, as it is intended to qualify as a “reorganization” within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended (the Code).

Our loss before taxes is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
U.S. loss before taxes	$	(347,226)	$	(223,519)	$	(159,089)
Foreign loss before taxes	(2,613)		(2,514)		(1,174)
Loss before income taxes	$	(349,839)	$	(226,033)	$	(160,263)

Income tax (expense) benefit consists of the following (in thousands):


	Year Ended December 31,
	2021		2020		2019
Current:
Federal	$	—	$	—	$	—
State	(9)		(5)		(3)
Foreign	—		—		—
Total current	(9)		(5)		(3)
Deferred:
Federal	—		1,187		77
State	—		664		31
Foreign	—		—		—
Total deferred	—		1,851		108
Total income tax (expense) benefit	$	(9)	$	1,846	$	105

The components that comprise our net deferred tax assets consist of the following (in thousands):


	As of December 31,
	2021		2020
Deferred tax assets:
Net operating loss carryforwards	$	314,612	$	223,123
Stock-based compensation	23,116		13,305
Research and development credits	17,716		21
Operating lease liabilities	10,316		5,456
Interest expense	8,531		5,055
Amortization	4,407		5,860
Depreciation	—		5,523
Investments	3,227		2,490
Accrued compensation	2,525		1,527
Other accrued liabilities	905		418
Other	2,055		3,334
Total deferred tax assets	387,410		266,112
Deferred tax liabilities:
Operating lease right-of-use assets	(9,345)		(4,668)
Depreciation	(2,905)		—
Indefinite-lived intangible assets	(162)		(170)
Total deferred tax liabilities	(12,412)		(4,838)
Net deferred tax assets	374,998		261,274
Valuation allowance	(375,160)		(261,444)
Net deferred tax liability	$	(162)	$	(170)

As of December 31, 2021, we have federal net operating losses (NOLs) of $1.3 billion, state NOLs of $1.2 billion, and foreign NOLs of $8.0 million. Of the $1.3 billion in federal NOLs, $850.3 million do not expire and will be able to be used to offset 80% of taxable income in future years. Of the $1.2 billion in state NOLs, $50.4 million do not expire and will be able to be used to offset 80% of taxable income in future years. The remaining federal NOL carryforwards expire beginning in 2022, the remaining state NOL carryforwards expire beginning in 2022, the South Korean NOL carryforwards expire beginning in 2022 and the Italian NOLs do not expire.

In assessing the realization of deferred tax assets, management considers whether it is more likely than not that some or all of our deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the periods in which those temporary differences become deductible. Management considers the scheduled reversal of deferred tax liabilities, projected future taxable income and tax planning strategies in making this assessment. Based on the level of historical operating results and the uncertainty of economic conditions, we have recorded a valuation allowance of $375.1 million and $261.4 million as of December 31, 2021 and 2020, respectively. The change in the valuation allowance for the years ended December 31, 2021 and 2020 were increases of $113.7 million and $63.4 million, respectively, which were mainly driven by losses from which we cannot benefit. The portion of the valuation allowance for deferred tax assets for which subsequently recognized tax benefits will be credited directly to contributed capital is $0.2 million.

A reconciliation of the federal statutory income tax rate to our effective income tax rate is as follows:


	Year Ended December 31,
	2021		2020		2019
Federal statutory tax rate	21.0	%	21.0	%	21.0	%
State income taxes, net of federal tax benefit	7.0	%	7.2	%	(0.8)	%
Other permanent items	(0.1)	%	(0.1)	%	1.6	%
Tax rate adjustment	1.5	%	(0.3)	%	0.2	%
Research and development credits	3.7	%	0.1	%	0.1	%
Stock-based compensation	0.5	%	1.3	%	(33.9)	%
Other	(0.9)	%	(0.2)	%	0.2	%
Valuation allowance	(32.7)	%	(28.2)	%	11.7	%
Effective income tax rate	0.0	%	0.8	%	0.1	%

Pursuant to Code Sections 382 and 383, annual use of our net operating loss and research and development credit carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period. We have not recognized the deferred tax assets for federal and state NOLs and credits of $274.2 million from our deferred tax asset schedules as of December 31, 2021 due to Section 382/383 limitations. There is no impact to tax expense for the derecognition of net operating losses, and federal and state research and development credits due to the valuation allowance recorded against our deferred tax assets.

As of December 31, 2021, we also had federal research tax credit carryforwards of $22.6 million and state research tax credits of $8.4 million. The federal research tax credit carryforwards expire beginning in 2032 and certain state research tax credit carryforwards expire beginning in 2030. Our California research tax credits can be carried forward indefinitely.

Net operating losses and tax credits also are limited when there is a separate return limitation year (SRLY). These rules generally limit the use of the acquired or departing members’ net operating loss and tax credit carryovers to the amount of taxable income such entity contributes to consolidated taxable income. The 80% limitation also applies to SRLY NOL carryovers and tax credits. Therefore, any SRLY NOLs and tax credits will be subject to this limitation, as well as Section 382 and 383 limitations.

As of December 31, 2021 and 2020, we have $33.1 million and $19.6 million of interest, respectively, that is temporarily disallowed pursuant to IRC Section 163(j). This interest can be carried forward indefinitely and will be deductible when the company generates sufficient adjusted taxable income.

On March 27, 2020, the U.S. enacted the Coronavirus Aid, Relief and Economic Security Act (the CARES Act). The Cares Act is an emergency economic stimulus package that includes spending and tax breaks to strengthen the U.S. economy and fund a nationwide effort to curtail the effect of COVID-19. The CARES Act provides sweeping tax changes in response to the COVID-19 pandemic. Under the CARES Act, some of the more significant provisions are NOL carrybacks for five years to offset previous years’ income, or can be carried forward indefinitely to offset 100% of taxable income for the tax year beginning before 2021 and 80% of taxable income for tax years 2021 and thereafter, increasing the ability to deduct interest expense, as well as amending certain provisions of the previously enacted Tax Cuts and Jobs Act. As of December 31, 2021 and 2020, we did not record any income tax (provision) benefit resulting from the CARES Act, mainly due to our history of net operating losses generated and the maintenance of a full valuation allowance against our net deferred tax assets. There was no material impact from the provisions of the Cares Act for the years ended December 31, 2021 and 2020.

On June 29, 2020, the state of California enacted Assembly Bill No. 85 (AB 85) suspending California NOL utilization and imposing a cap on the amount of business incentive tax credits companies can utilize, effective for tax years 2020, 2021 and 2022. There was no material impact from the provisions of AB 85 for the years ended December 31, 2021 and 2020. On February 9, 2022, Senate Bill No. 113 was enacted that removed the limitations on the use of NOLs and the cap on the business incentive tax credits that were suspended in accordance with AB 85 effective for tax year 2022.

A summary of changes to the amount of unrecognized tax benefits is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
Unrecognized tax benefits, beginning of year	$	20,413	$	15,656	$	11,983
Additions based on tax positions related to the current year	536		4,763		3,680

Reductions for tax positions of prior years	(7,445)		(6)		(7)

Unrecognized tax benefits, end of year	$	13,504	$	20,413	$	15,656

Included in the balance of unrecognized tax benefits as of December 31, 2021 is $11.4 million that, if recognized, would not impact our income tax benefit or effective tax rate as long as the deferred tax asset remains subject to a full valuation allowance. We do not expect that the unrecognized tax benefits will change within 12 months of December 31, 2021. Due to the existence of the valuation allowance, future changes in our unrecognized tax benefits will not impact our effective tax rate. We have not incurred any material interest or penalties as of the current reporting date with respect to income tax matters.

Prior to the adoption of ASU 2019‑12 in the first quarter of 2020, intra-period tax allocation rules required us to allocate the provision for income taxes between continuing operations and other categories of earnings, such as other comprehensive (loss) income. In periods in which we had a year-to-date pre-tax loss from continuing operations and pre-tax income in other categories of earnings, such as other comprehensive (loss) income, we had to allocate the tax provision to the other categories of earnings. We then recorded a related tax benefit in continuing operations. However, with the adoption of ASU 2019‑12, we are no longer required to allocate the tax provision to the other categories of earnings and related benefits to continuing operations under these circumstances.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 21
-URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32857-109319

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 11.C)
-URI http://asc.fasb.org/extlink&oid=122134291&loc=d3e330215-122817

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 17
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32809-109319

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 6.I.5.Q1)
-URI http://asc.fasb.org/extlink&oid=122134291&loc=d3e330036-122817

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 14
-URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32705-109319

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 270
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6424409&loc=d3e44925-109338

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-URI http://asc.fasb.org/topic&trid=2144680

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 30
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=6424122&loc=d3e41874-109331

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h)(2))
-URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

+ Details

Employee Benefits	12 Months Ended
Employee Benefits	Dec. 31, 2021
Compensation Related Costs [Abstract]
Employee Benefits	Employee Benefits Defined Contribution Benefit Plan In December 2015, we adopted a 401(k) retirement and savings plan (the 401(k) Plan) covering all employees. The 401(k) Plan allows employees to make pre- and post-tax contributions up to the maximum allowable amount set by the IRS. The company, at its discretion, may make certain contributions to the 401(k) Plan. We made contributions totaling $1.7 million, $1.1 million and $0.9 million to the 401(k) Plan for the years ended December 31, 2021, 2020 and 2019, respectively. Compensated Absences Under our vacation policy, salaried employees are provided unlimited vacation leave. Therefore, we do not record an accrual for paid leave related to these employees since we are unable to reasonably estimate the compensated absences that these employees will take.

Subsequent Events	12 Months Ended
Subsequent Events	Dec. 31, 2021
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events Increase in Shares of Common Stock Authorized for Issuance Effective February 1, 2022, ImmunityBio amended its Amended and Restated Certificate of Incorporation to increase the number of shares that the company is authorized to issue from 500,000,000 shares of common stock, $0.0001 par value per share, to 900,000,000 shares of common stock, $0.0001 par value per share. The number of shares of preferred stock, $0.0001 par value per share, that the company is authorized to issue remained unchanged at 20,000,000 shares. Acquisition of cGMP ISO Class 5 Manufacturing Facility On February 14, 2022, we acquired a leasehold interest in approximately 409,000 rentable square feet of cGMP ISO Class 5 pharmaceutical manufacturing space in western New York (the Dunkirk Facility) from Athenex, Inc. (Athenex). This facility provides us with a state-of-the-art biotech production center that substantially expands and diversifies our existing manufacturing capacity in the U.S. We paid approximately $40.0 million to Athenex, and the leasehold interest in the Dunkirk Facility was transferred to us. Our annual lease payment will be $2.00 per year for an initial 10-year term, with an option to renew the lease under substantially the same terms and conditions for an additional 10-year term. As part of the transaction, we assumed obligations under various third-party agreements, and committed to spend $1.52 billion on operational expenses during the initial term, and an additional $1.50 billion on operational expenses if we elect to renew the lease for the additional 10-year term. We also committed to hiring 450 employees at the Dunkirk Facility within the first five years of operations, with 300 such employees to be hired within the first 2.5 years of operations. We are eligible for certain sales-tax exemption savings during the development of the Dunkirk Facility, and certain property tax savings over the next 20 years, subject to certain terms and conditions, including performance of certain of the obligations described above.

Summary of Significant Accounting Policies (Policies)

12 Months Ended

Dec. 31, 2021

Accounting Policies [Abstract]

Accounting Treatment of the Merger

Basis of Presentation

Principles of Consolidation

Use of Estimates

Contingencies

Concentration of Credit Risk and Other Risks and Uncertainties

Financial instruments that potentially subject us to concentrations of risk consist principally of cash and cash equivalents, marketable securities, and a convertible note receivable.

Cash, Cash Equivalents and Restricted Cash

Cash equivalents include highly liquid investments with an original maturity of three months or less from the date of purchase.

Marketable Securities and Other Investments

Marketable Debt Securities

Marketable Equity Securities

Non-Marketable Equity Securities

Evaluating Investments for Other-than-Temporary Impairments

Equity Method of Accounting

Equity Method of AccountingIn circumstances where we have the ability to exercise significant influence over the operating and financial policies of a company in which we have an investment, we utilize the equity method of accounting for recording investment activity. In assessing whether we exercise significant influence, we consider the nature and magnitude of our investment, the voting and protective rights we hold, any participation in the governance of the other company and other relevant factors such as the presence of a collaborative or other business relationship. Under the equity method of accounting, we record our share of the income or loss of the other company as gain (loss) on equity method investment, in our consolidated statements of operations.

Property, Plant and Equipment, Net


Buildings						39 years
Software						3 years
Laboratory equipment						5 to 7 years
Furniture & fixtures						5 years
IT equipment						3 years
Leasehold improvements						The lesser of the lease term or life of the asset

Property, Plant and Equipment, Net, Impairment

Business Combinations

Common Control Transactions

Common Control TransactionsTransactions between us and entities where Dr. Soon-Shiong and his affiliates are the controlling stockholders are accounted for as common control transactions whereby the net assets acquired or transferred are accounted at their carrying value. Any difference between the carrying value and consideration recognized is treated as a capital transaction. Cash consideration up to the carrying value of the net assets acquired or transferred is presented as an investing activity in our consolidated statements of cash flows. Cash consideration in excess of the carrying value of the net assets acquired or transferred is presented as a financing activity in our consolidated statements of cash flows.

Intangible Assets, Net

Acquired definite-lived intangible assets are amortized using the straight-line method over their respective estimated useful lives.

Patents

Patent costs, including related legal costs, are expensed as incurred and recorded in selling, general and administrative expense on the consolidated statements of operations.

Fair Value of Financial Instruments

The three tiers are defined as follows:

•Level 3—Valuations based on inputs that are unobservable and significant to the overall fair value measurement.

During the years ended December 31, 2021, 2020 and 2019, no transfers were made into or out of the Level 1, 2 or 3 categories. We will continue to review the fair value inputs on a quarterly basis.

Collaboration Arrangements

Preclinical and Clinical Trial Accruals

Transactions with Related Parties

Lease Obligations

The depreciable life of operating right-of-use-assets and leasehold improvements is limited by the expected lease term.

Sale-Leaseback Transaction

Income Taxes

Stock Repurchases

Revenue Recognition

Research and Development Costs

Stock-Based Compensation

Stock-Based CompensationWe account for stock-based compensation under the provisions of ASC Topic 718, Compensation—Stock Compensation (ASC 718). We estimate fair value of each stock option award on the date of grant using the Black-Scholes option pricing model. The Black-Scholes model requires the use of highly subjective assumptions, including, but not limited to, expected stock price volatility over the term of the awards and the expected term of the stock options. We measure the fair value of an equity-classified award at the grant date and recognize the stock-based compensation expense over the period of vesting on the straight-line basis for our outstanding share awards that do not contain a performance condition. For awards subject to performance-based vesting conditions, we assess the probability of the individual milestones under the award being achieved and stock-based compensation expense is recognized over the service period using the graded vesting method once management believes the performance criteria is probable of being met. For awards with service or performance conditions, we recognize the effect of forfeitures in compensation cost in the period that the award was forfeited. See Note 10, Stock-Based Compensation.

Sale-leaseback Transaction

Lease Obligations

The depreciable life of operating right-of-use-assets and leasehold improvements is limited by the expected lease term.

Sale-Leaseback Transaction

Comprehensive Income (Loss)

Noncontrolling Interests

Noncontrolling InterestsNoncontrolling interests are recorded for the entities that we consolidate but are not wholly-owned by the company. Noncontrolling interests are classified as a separate component of equity on the consolidated balance sheets and consolidated statements of stockholders’ deficit. Additionally, net loss attributable to noncontrolling interests is reflected separately from consolidated net loss on the consolidated statements of operations and the consolidated statements of stockholders’ deficit. We record the noncontrolling interests’ share of loss based on the percentage of ownership interest retained by the respective noncontrolling interest holders.

Foreign Currencies

Basic and Diluted Net Loss Per Share of Common Stock

Basic and Diluted Net Loss per Share of Common Stock

Segment and Geographic Information

Segment and Geographic InformationWe operate in one reporting segment focused on creating the next generation of immunotherapies to address serious unmet needs within oncology and infectious diseases. Our chief executive officer (CEO) is the chief operating decision-maker (CODM) of the company, and manages and allocates resources to our operations on a company-wide basis. Consistent with this decision-making process, our CEO uses consolidated, single-segment financial information for purposes of evaluating performance, forecasting future-period financial results, allocating resources and setting incentive targets.

Recent Accounting Pronouncements

Application of New or Revised Accounting Standards – Adopted

Application of New or Revised Accounting Standards – Not Yet Adopted

Description of Business (Tables)

12 Months Ended

Dec. 31, 2021

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Impact of Change in Reporting Entity on Unaudited Consolidated Statements of Operations


	Three Months Ended March 31, 2021
	(Unaudited)
	NantCell		NantKwest		Intercompany Eliminations		ImmunityBio, Inc.
Revenue	$	183	$	—	$	(44)	$	139
Operating expenses:
Research and development (including amounts with related parties)	21,509		19,725		(106)		41,128
Selling, general and administrative (including amounts with related parties)	24,382		20,903		(10)		45,275
Loss from operations	(45,708)		(40,628)		72		(86,264)
Other (expense) income, net (including amounts with related parties)	(848)		6,637		—		5,789
Income tax expense	—		(6)		—		(6)
Net loss	$	(46,556)	$	(33,997)	$	72	$	(80,481)


	Year ended December 31, 2020
	(Unaudited)
	NantCell		NantKwest		Intercompany Eliminations		ImmunityBio, Inc.
Revenue	$	1,695	$	111	$	(1,201)	$	605
Operating expenses:
Research and development (including amounts with related parties)	75,763		64,483		(739)		139,507
Selling, general and administrative (including amounts with related parties)	44,099		27,254		(35)		71,318
Impairment of intangible assets	10,660		—		—		10,660
Loss from operations	(128,827)		(91,626)		(427)		(220,880)
Other (expense) income, net (including amounts with related parties)	(4,401)		(752)		—		(5,153)
Income tax benefit (expense)	1,851		(5)		—		1,846
Net loss	$	(131,377)	$	(92,383)	$	(427)	$	(224,187)


	Year ended December 31, 2019
	(Unaudited)
	NantCell		NantKwest		Intercompany Eliminations		ImmunityBio, Inc.
Revenue	$	2,994	$	43	$	(835)	$	2,202
Operating expenses:
Research and development (including amounts with related parties)	62,253		49,785		(41)		111,997
Selling, general and administrative (including amounts with related parties)	28,391		18,065		—		46,456
Loss from operations	(87,650)		(67,807)		(794)		(156,251)
Other (expense) income, net (including amounts with related parties)	(6,162)		1,921		229		(4,012)
Income tax benefit	8		97		—		105
Net loss	$	(93,804)	$	(65,789)	$	(565)	$	(160,158)

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2021

Accounting Policies [Abstract]

Estimated Useful Lives of Property, Plant and Equipment

Depreciation of property, plant and equipment is calculated using the straight-line method over the estimated useful lives of the assets, as follows:


Buildings						39 years
Software						3 years
Laboratory equipment						5 to 7 years
Furniture & fixtures						5 years
IT equipment						3 years
Leasehold improvements						The lesser of the lease term or life of the asset

Property, plant and equipment, net, consist of the following (in thousands):




	As of December 31,
	2021		2020
Leasehold improvements	$	62,482	$	52,251
Equipment	54,284		34,738
Construction in progress	16,575		1,333
Software	1,544		2,376
Furniture & fixtures	1,052		1,015
Building	—		22,690
Gross property, plant and equipment	135,937		114,403
Less: Accumulated depreciation and amortization	53,074		41,862
Property, plant and equipment, net	$	82,863	$	72,541

Securities Excluded from the Computation of Potentially Dilutive Securities

The following table details those securities that have been excluded from the computation of potentially dilutive securities:


	As of December 31,
	2021	2020	2019
Outstanding stock options	4,124,930	4,996,284	6,080,483
Outstanding RSUs	6,515,889	466,842	1,155,808
Outstanding related-party warrants	1,638,000	1,638,000	1,638,000
Total	12,278,819	7,101,126	8,874,291

Schedule of Revenue by Geographic Region

We generate a portion of its revenues from outside of the U.S. Information about our revenues from the different geographic regions is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
United States	$	373	$	513	$	1,997
Europe	561		92		205
Total segment revenue	$	934	$	605	$	2,202

Financial Statement Details (Tables)

12 Months Ended

Dec. 31, 2021

Financial Statement Details [Abstract]

Property, Plant and Equipment, Net

Depreciation of property, plant and equipment is calculated using the straight-line method over the estimated useful lives of the assets, as follows:


Buildings						39 years
Software						3 years
Laboratory equipment						5 to 7 years
Furniture & fixtures						5 years
IT equipment						3 years
Leasehold improvements						The lesser of the lease term or life of the asset

Property, plant and equipment, net, consist of the following (in thousands):




	As of December 31,
	2021		2020
Leasehold improvements	$	62,482	$	52,251
Equipment	54,284		34,738
Construction in progress	16,575		1,333
Software	1,544		2,376
Furniture & fixtures	1,052		1,015
Building	—		22,690
Gross property, plant and equipment	135,937		114,403
Less: Accumulated depreciation and amortization	53,074		41,862
Property, plant and equipment, net	$	82,863	$	72,541

Accrued Expenses and Other Liabilities

Accrued expenses and other liabilities consist of the following (in thousands):




	As of December 31,
	2021		2020
Accrued bonus	$	8,316	$	5,288
Accrued construction costs	8,145		—
Accrued dissenting shares (Note 7)	7,118		6,769
Accrued professional and service fees	6,909		7,668
Accrued preclinical and clinical trial costs	5,842		4,339

Accrued compensation	5,613		3,891








Other	9,444		8,816
Accrued expenses and other liabilities	$	51,387	$	36,771

Interest and Investment (Loss) Income, Net

Interest and investment (loss) income, net consists of the following (in thousands):


	Year Ended December 31,
	2021		2020		2019
Unrealized (losses) gains from equity securities	$	(4,615)	$	1,577	$	(321)
Interest income	836		1,725		2,764
Investment (amortization expense) accretion income, net	(488)		(858)		3
Net realized gains (losses) on investments	167		(9)		(4)
Interest and investment (loss) income, net	$	(4,100)	$	2,435	$	2,442

Financial Instruments (Tables)

12 Months Ended

Dec. 31, 2021

Investments, Debt and Equity Securities [Abstract]

Summary of Available-for-Sale Marketable Debt Securities


	December 31, 2021
	Weighted- Average Remaining Contractual Life (in years)	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Current:
Corporate debt securities	0.5	$	129,190	$	10	$	(36)	$	129,164
Foreign bonds	0.4	116		—		(1)		115
Mutual funds		35		3		—		38
Current portion		129,341		13		(37)		129,317
Noncurrent:
Foreign bonds	5.0	719		103		—		822
Noncurrent portion		719		103		—		822
Total		$	130,060	$	116	$	(37)	$	130,139


	December 31, 2020
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Current:
Corporate debt securities	$	54,789	$	2	$	(19)	$	54,772
Mutual funds	35		2		—		37
Current portion	54,824		4		(19)		54,809
Noncurrent:
Foreign bonds	861		89		—		950
Noncurrent portion	861		89		—		950
Total	$	55,685	$	93	$	(19)	$	55,759

Accumulated Unrealized Losses on Debt Securities Classified as Available-for-Sale in Continuous Loss Position

Accumulated unrealized losses on marketable debt securities that have been in a continuous loss position for less than 12 months and more than 12 months were as follows (in thousands):


	December 31, 2021
	Less than 12 months				More than 12 months
	Estimated Fair Value		Gross Unrealized Losses		Estimated Fair Value		Gross Unrealized Losses
Corporate debt securities	$	86,158	$	(36)	$	—	$	—
Mutual funds	—		—		34		(2)
Foreign bonds	115		(1)		113		(1)
Total	$	86,273	$	(37)	$	147	$	(3)


	December 31, 2020
	Less than 12 months				More than 12 months
	Estimated Fair Value		Gross Unrealized Losses		Estimated Fair Value		Gross Unrealized Losses
Corporate debt securities	$	42,762	$	(19)	$	—	$	—
Total	$	42,762	$	(19)	$	—	$	—

Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2021

Fair Value Disclosures [Abstract]

Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis

Financial assets and liabilities measured at fair value on a recurring basis are summarized below (in thousands):


	Fair Value Measurements at December 31, 2021
	Total			Level 1		Level 2		Level 3
Assets:
Current:
Cash and cash equivalents	$	181,101	(1)	$	51,421	$	129,680	$	—
Equity securities	6,698		(2)	6,698		—		—
Corporate debt securities	129,164			—		129,164		—
Foreign bonds	115			115		—		—
Mutual funds	38			38		—		—
Noncurrent:
Foreign bonds	822			822		—		—
Total assets measured at fair value	$	317,938		$	59,094	$	258,844	$	—
Liabilities:
Contingent consideration	$	(409)	(3)	$	(388)	$	—	$	(21)


	Fair Value Measurements at December 31, 2020
	Total			Level 1		Level 2		Level 3
Assets:
Current:
Cash and cash equivalents	$	34,915		$	34,915	$	—	$	—
Corporate debt securities	54,772			—		54,772		—
Equity securities	6,337			6,337		—		—
Mutual funds	37			37		—		—
Noncurrent:
Foreign bonds	950			950		—		—
Total assets measured at fair value	$	97,011		$	42,239	$	54,772	$	—
Liabilities:
Contingent consideration	$	(972)	(3)	$	—	$	—	$	(972)

_______________


(1)			Amounts shown as a Level 2 measurement include government-sponsored securities of $75.0 million, corporate debt securities of $54.2 million, and commercial paper of $0.5 million with original maturities of less than 90 days.


(2)			Our equity securities include a $5.7 million investment in Viracta. As of December 31, 2020, the carrying value of our investment in Viracta, which was reflected in non-marketable equity investment, on the consolidated balance sheets, was $7.8 million.


(3)			Contingent consideration is recorded at estimated fair value and revalued each reporting period until the related contingency is resolved. The fair value measurement is based on inputs that are unobservable and significant to the overall fair value measurement (i.e., a Level 3 measurement within the fair value hierarchy) and are reviewed periodically by management. See Note 7, Commitments and Contingencies—Contingent Consideration Related to Business Combinations, for further information.

Summary of Changes in Carrying Amount of Contingent Consideration

Changes in the carrying amount of contingent consideration were as follows (in thousands):


	For the Year Ended December 31,
	2021		2020		2019
Fair value, beginning of year	$	(972)	$	(1,725)	$	(1,004)
Consideration paid	419		—		(786)
Net decrease in fair value	144		753		65
Fair value, end of year	$	(409)	$	(972)	$	(1,725)

Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2021

Commitments and Contingencies Disclosure [Abstract]

Summary of Information Regarding Leases

Information regarding our leases is as follows:


	As of December 31,
	2021		2020
Weighted average remaining lease term	7.8 years		3.9 years
Weighted average discount rate	9.6	%	9.0	%

The components of lease expense consist of the following (in thousands):


	Year Ended December 31,
	2021		2020		2019
Operating lease costs	$	7,977	$	5,668	$	5,795
Variable lease costs	2,862		3,564		2,764
Total lease costs	$	10,839	$	9,232	$	8,559

Cash paid for amounts included in the measurement of lease liabilities is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
Cash paid for operating leases (excluding variable lease costs)	$	9,034	$	7,843	$	7,571

Summary of Future Minimum Lease Payments


Years ending December 31:	Operating Leases
2022	$	8,962
2023	8,316
2024	7,768
2025	7,214
2026	5,259
Thereafter	26,098
Total future minimum lease payments	63,617
Less: Interest	20,597
Less: Tenant improvement allowance receivable	2,941
Present value of operating lease liabilities	$	40,079

Related-Party Agreements (Tables)

12 Months Ended

Dec. 31, 2021

Summary of Outstanding Balances of Related Party Agreements

Below is a summary of outstanding balances and a description of significant relationships (in thousands):




	As of December 31,
	2021		2020
Due from related party–NantBio, Inc.	$	1,294	$	1,294
Due from related party–NantOmics LLC	—		591
Due from related parties–Various	39		118
Total due from related parties	$	1,333	$	2,003

Due to related party–NantWorks	$	1,113	$	10,650
Due to related party–Duley Road, LLC	1,380		2,787
Due to related party–NantBio, Inc.	943		943
Due to related party–605 Nash, LLC	—		—
Due to related party–Immuno-Oncology Clinic, Inc.	507		271
Due to related party–Various	—		187
Total due to related parties	$	3,943	$	14,838

Summary of Related Party Notes Payable

Our related-party notes payable consist of the following (in thousands):


						Total Notes and Interest Payable as of December 31,
Related-Party Notes Payable	Note Year	Outstanding Advances		Interest Rate		2021			2020

Nant Capital (1)	2021	$	300,000	SOFR + 5.4%		$	299,236	(1)	$	—
Nant Capital (2)	2015	55,226		5.0	%	61,367		(3)	58,482		(3)
Nant Capital (2)	2020	50,000		6.0	%	53,810		(4)	50,764		(4)
Nant Capital (5)	2021	40,000		6.0	%	40,000		(5)	—
NantMobile (2)	2019	55,000		3.0	%	58,359		(6)	56,660		(6)
NantWorks (2)	2017	43,418		5.0	%	54,067		(7)	51,546		(7)
NCSC (2)	2018	33,000		5.0	%	38,746		(8)	36,901		(8)
Total related-party notes payable		$	576,644			$	605,585		$	254,353

_______________


(1)			The outstanding advance is due and payable on December 17, 2022. This loan bears interest at Term SOFR + 5.4%, which is compounded annually and payable quarterly commencing on March 17, 2022. As of December 31, 2021, the interest rate on this loan was 5.47%. Accrued and unpaid interest on this note totaled $0.7 million as of December 31, 2021. In the event of a default on the loan (as defined in the promissory note), including if we do not repay the loan at maturity, the company has the right, at its sole option, to convert the outstanding principal amount and accrued and unpaid interest due under this note into fully paid and non-assessable shares of the company’s common stock at a price per share equal to $5.67. Debt issuance cost of $1.5 million paid to the lender in December 31, 2021 was recorded as a reduction of the principal amount of the note.

(2)			All outstanding advances and accrued and unpaid interest is due and payable on September 30, 2025. Interest on related-party notes payable is compounded annually. We may prepay the outstanding principal at any time without premium, penalty or the prior consent of the issuer. All outstanding amounts under the notes become due and payable upon certain bankruptcy and insolvency-related events. There are no equity or equity-linked convertible rights related to these promissory notes.

(3)			Accrued and unpaid interest on this note totaled $6.1 million and $3.3 million as of December 31, 2021 and 2020, respectively.

(4)			Accrued and unpaid interest on this note totaled $3.8 million and $0.8 million as of December 31, 2021 and 2020, respectively.

(5)			The outstanding principal is due and payable on September 30, 2025. Interest on this related-party note is compounded annually and payable quarterly commencing on June 30, 2021. We paid $2.0 million in interest on this loan during the year ended December 31, 2021. All outstanding amounts under the note become due and payable upon certain bankruptcy and insolvency-related events. There are no equity or equity-linked convertible rights related to this promissory note.

(6)			Accrued and unpaid interest on this note totaled $3.4 million and $1.7 million as of December 31, 2021 and 2020, respectively.

(7)			Accrued and unpaid interest on this note totaled $10.6 million and $8.1 million as of December 31, 2021 and 2020, respectively.

(8)			Accrued and unpaid interest on this note totaled $5.7 million and $3.9 million as of December 31, 2021 and 2020, respectively.

Estimated Future Contractual Obligations for Related-Party Notes Payable

The following table summarizes our estimated future contractual obligations for related-party notes payable as of December 31, 2021 (in thousands):


	Principal Payments		Interest Payments (1)			Total
2022	$	300,000	$	18,808	(2)	$	318,808
2023	—		2,400			2,400
2024	—		2,407			2,407
2025	276,644		85,823		(3)	362,467
Total principal and estimated interest due on related-party notes	$	576,644	$	109,438		$	686,082

_______________


(1)			Interest payments on our fixed-rate debt are calculated based on contractual interest rates and scheduled maturity dates. Interest payments on our variable-rate debt are calculated based on schedule maturity dates and the Term SOFR rate plus the contractual spread per the loan agreement. The rate on this debt as of December 31, 2021 was 5.47%.

(2)			Interest shown includes $0.7 million of accrued and unpaid interest as of December 31, 2021 related to the $300.0 million variable-rate loan. Interest on our $300.0 million variable-rate loan and our $40.0 million fixed-rate loan are payable on a monthly and quarterly basis, respectively.

(3)			Interest shown includes $29.7 million of accrued and unpaid interest of December 31, 2021. Interest on these notes is payable at maturity on September 30, 2025.

Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Stock-Based Compensation Expenses Related to Statement of Operations

The following table presents stock-based compensation included on the consolidated statements of operations (in thousands):


	Year Ended December 31,
	2021		2020		2019
Stock-based compensation expense:
Stock options	$	11,623	$	1,426	$	2,053
RSUs	45,558		761		1,368
	$	57,181	$	2,187	$	3,421
Stock-based compensation expense in operating expenses:
Research and development	$	18,819	$	261	$	1,288
Selling, general and administrative	38,362		1,926		2,133
	$	57,181	$	2,187	$	3,421

Summary of Stock Option Activity and Related Information under Equity Plans

The following table summarizes stock option activity and related information for the year ended December 31, 2021:


	Number of Options	Weighted- Average Exercise Price		Aggregate Intrinsic Value (in thousands)		Weighted- Average Remaining Contractual Life (in years)
Outstanding at December 31, 2020	4,996,284	$	9.96	$	29,746	4.7
Granted	1,069,940	$	21.38
Exercised	(1,817,300)	$	3.95
Expired/forfeited	(123,994)	$	10.10
Outstanding at December 31, 2021	4,124,930	$	15.62	$	4,178	5.3
Vested and exercisable at December 31, 2021	3,038,322	$	13.89	$	3,978	3.9

Weighted Average Fair Value of Options Under Black-Scholes Option Pricing Model

The fair value of stock options issued was estimated at the date of grant using the Black-Scholes option pricing model with the following weighted-average assumptions:


	Year Ended December 31,
	2021			2020			2019
Expected life (in years)	5.9 years			5.5 years			N/A
Risk-free interest rate	0.7		%	0.4		%	N/A
Volatility factor	101.0		%	96.8		%	N/A
Dividend yield	0.0		%	0.0		%	N/A
Weighted-average grant date fair value	$	16.80		$	4.64		N/A

Summary of RSU Activity under Equity Plans

The following table summarizes RSU activity during the year ended December 31, 2021:


	Number of Units	Weighted- Average Grant Date Fair Value
Nonvested balance at December 31, 2020	466,842	$	2.52
Granted	8,665,942	$	23.27
Vested	(873,058)	$	19.61
Forfeited/canceled	(1,743,837)	$	24.77
Nonvested balance at December 31, 2021	6,515,889	$	21.88

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Loss Before Taxes, Domestic and Foreign

Our loss before taxes is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
U.S. loss before taxes	$	(347,226)	$	(223,519)	$	(159,089)
Foreign loss before taxes	(2,613)		(2,514)		(1,174)
Loss before income taxes	$	(349,839)	$	(226,033)	$	(160,263)

Schedule of Components of Income Tax Benefit (Provision)

Income tax (expense) benefit consists of the following (in thousands):


	Year Ended December 31,
	2021		2020		2019
Current:
Federal	$	—	$	—	$	—
State	(9)		(5)		(3)
Foreign	—		—		—
Total current	(9)		(5)		(3)
Deferred:
Federal	—		1,187		77
State	—		664		31
Foreign	—		—		—
Total deferred	—		1,851		108
Total income tax (expense) benefit	$	(9)	$	1,846	$	105

Schedule of Deferred Tax Assets and Liabilities

The components that comprise our net deferred tax assets consist of the following (in thousands):


	As of December 31,
	2021		2020
Deferred tax assets:
Net operating loss carryforwards	$	314,612	$	223,123
Stock-based compensation	23,116		13,305
Research and development credits	17,716		21
Operating lease liabilities	10,316		5,456
Interest expense	8,531		5,055
Amortization	4,407		5,860
Depreciation	—		5,523
Investments	3,227		2,490
Accrued compensation	2,525		1,527
Other accrued liabilities	905		418
Other	2,055		3,334
Total deferred tax assets	387,410		266,112
Deferred tax liabilities:
Operating lease right-of-use assets	(9,345)		(4,668)
Depreciation	(2,905)		—
Indefinite-lived intangible assets	(162)		(170)
Total deferred tax liabilities	(12,412)		(4,838)
Net deferred tax assets	374,998		261,274
Valuation allowance	(375,160)		(261,444)
Net deferred tax liability	$	(162)	$	(170)

Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate

A reconciliation of the federal statutory income tax rate to our effective income tax rate is as follows:


	Year Ended December 31,
	2021		2020		2019
Federal statutory tax rate	21.0	%	21.0	%	21.0	%
State income taxes, net of federal tax benefit	7.0	%	7.2	%	(0.8)	%
Other permanent items	(0.1)	%	(0.1)	%	1.6	%
Tax rate adjustment	1.5	%	(0.3)	%	0.2	%
Research and development credits	3.7	%	0.1	%	0.1	%
Stock-based compensation	0.5	%	1.3	%	(33.9)	%
Other	(0.9)	%	(0.2)	%	0.2	%
Valuation allowance	(32.7)	%	(28.2)	%	11.7	%
Effective income tax rate	0.0	%	0.8	%	0.1	%

Schedule of Changes to Unrecognized Tax Benefits

A summary of changes to the amount of unrecognized tax benefits is as follows (in thousands):


	Year Ended December 31,
	2021		2020		2019
Unrecognized tax benefits, beginning of year	$	20,413	$	15,656	$	11,983
Additions based on tax positions related to the current year	536		4,763		3,680

Reductions for tax positions of prior years	(7,445)		(6)		(7)

Unrecognized tax benefits, end of year	$	13,504	$	20,413	$	15,656

Description of Business - Additional Information (Detail) $ / shares in Units, $ in Millions		12 Months Ended
	Mar. 09, 2021 $ / shares	Dec. 31, 2021 USD ($) $ / shares	Dec. 31, 2021 USD ($) $ / shares	Dec. 31, 2020 USD ($) $ / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001	$ 0.0001	$ 0.0001
NantKwest
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Ownership percentage held by stockholders upon consummation of merger	28.50%
Executive Chairman and Global Chief Scientific and Medical Officer
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Ownership percentage held by Executive Chairman and Global Chief Scientific and Medical Officer upon consummation of merger	81.80%
Selling General and Administrative Expense
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Merger-related costs \| $		$ 13.0	$ 23.3	$ 10.3
NantCell
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock, par value (in dollars per share)	$ 0.001
Merger exchange ratio	0.8190
Ownership percentage held by stockholders upon consummation of merger	71.50%

Summary of Significant Accounting Policies - Additional Information (Detail)			1 Months Ended	3 Months Ended	12 Months Ended
	Apr. 30, 2021 USD ($)	Mar. 09, 2021	Sep. 30, 2021 option	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($) segment	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Accounting Policies [Line Items]
Accumulated deficit					$ 1,961,921,000	$ 1,615,131,000
Net cash used in operating activities					(274,419,000)	(171,724,000)	$ (152,109,000)
Other than temporary impairment losses					$ 0	0	0
Estimated useful life, intangible asset					4 years
Revenue				$ 139,000	$ 934,000	605,000	2,202,000
Operating Expenses					331,214,000	221,485,000	158,453,000
Assets					468,910,000	221,381,000
Liabilities					$ 712,823,000	$ 339,871,000
Deconsolidation of Precision Biologics							$ 18,353,000
Number of operating segments \| segment					1
Number of reportable segments \| segment					1
GlobeImmune, Inc.
Accounting Policies [Line Items]
Percentage of ownership interest by parent					69.10%	69.10%	69.10%
NANTibody, LLC
Accounting Policies [Line Items]
Percentage of ownership interest by parent					60.00%	60.00%	60.00%
Precision Biologics, Inc.
Accounting Policies [Line Items]
Percentage of ownership interest by parent							68.50%
NC 2015 Plan and NantCell Warrants
Accounting Policies [Line Items]
Merger exchange ratio		0.8190
NantCell
Accounting Policies [Line Items]
Merger exchange ratio		0.8190
557 South Douglas Street
Accounting Policies [Line Items]
Optional extended lease term			7 years
Nant Capital \| 557 South Douglas Street
Accounting Policies [Line Items]
Initial term of lease arrangement			7 years
Options to extend number of terms \| option			2
Optional extended lease term			7 years
Maximum
Accounting Policies [Line Items]
Initial term of lease arrangement					10 years
Minimum
Accounting Policies [Line Items]
Initial term of lease arrangement					2 years
ATM Offering Program
Accounting Policies [Line Items]
Available for future stock issuance					$ 330,800,000
ATM Offering Program \| Maximum
Accounting Policies [Line Items]
Maximum aggregate offering price	$ 500,000,000
License Agreement
Accounting Policies [Line Items]
Revenue					0
GlobeImmune, Inc.
Accounting Policies [Line Items]
Revenue							$ 200,000
Promissory note agreement					$ 6,000,000
Interest Rate					5.00%
Advances to support operations					$ 0	$ 0
Operating Expenses					700,000	2,000,000	$ 7,700,000
Assets					800,000	500,000
Liabilities					$ 0	$ 300,000

Summary of Significant Accounting Policies - Estimated Useful Lives of Property, Plant and Equipment (Details)	12 Months Ended
	Dec. 31, 2021
Buildings
Property Plant And Equipment [Line Items]
Useful life	39 years
Software
Property Plant And Equipment [Line Items]
Useful life	3 years
Laboratory equipment \| Minimum
Property Plant And Equipment [Line Items]
Useful life	5 years
Laboratory equipment \| Maximum
Property Plant And Equipment [Line Items]
Useful life	7 years
Furniture & fixtures
Property Plant And Equipment [Line Items]
Useful life	5 years
IT equipment
Property Plant And Equipment [Line Items]
Useful life	3 years

Summary of Significant Accounting Policies - Securities Excluded from the Computation of Potentially Dilutive Securities (Detail) - shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	12,278,819	7,101,126	8,874,291
Stock Options
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	4,124,930	4,996,284	6,080,483
RSUs
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	6,515,889	466,842	1,155,808
Related-party warrants
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	1,638,000	1,638,000	1,638,000

Summary of Significant Accounting Policies - Revenue by Geographic Region (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenue	$ 139	$ 934	$ 605	$ 2,202
United States
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenue		373	513	1,997
Europe
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenue		$ 561	$ 92	$ 205

- Definition

Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8736-108599

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 323
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=114001798&loc=d3e33918-111571

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
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-Section 50
-Paragraph 28
-Subparagraph (f)
-URI http://asc.fasb.org/extlink&oid=123596393&loc=d3e14064-108612

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
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-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8933-108599

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
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-Paragraph 32
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-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8933-108599

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
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-Paragraph 1B
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-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442552-122756

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
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Reference 22: http://www.xbrl.org/2009/role/commonPracticeRef
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Reference 23: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Subparagraph (SX 210.5-03(1))
-URI http://asc.fasb.org/extlink&oid=123367319&loc=SL114868664-224227

+ Details

Financial Statement Details - Property, Plant and Equipment, Net (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	$ 135,937	$ 114,403
Less: Accumulated depreciation and amortization	53,074	41,862
Property, plant and equipment, net	82,863	72,541
Leasehold improvements
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	62,482	52,251
Equipment
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	54,284	34,738
Construction in progress
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	16,575	1,333
Software
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	1,544	2,376
Furniture & fixtures
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	1,052	1,015
Building
Property Plant And Equipment [Line Items]
Gross property, plant and equipment	$ 0	$ 22,690

Financial Statement Details - Additional Information (Detail)	1 Months Ended	12 Months Ended
	Sep. 30, 2021 USD ($) option	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Financial Statement Details [Line Items]
Sale of assets to an entity under common control		$ 1,435,000	$ 0	$ 0
Depreciation and amortization		14,238,000	12,739,000	14,042,000
Impairment of intangible assets		$ 0	$ 10,660,000	$ 0
557 South Douglas Street
Financial Statement Details [Line Items]
Optional extended lease term	7 years
Nant Capital \| 557 South Douglas Street
Financial Statement Details [Line Items]
Initial term of lease arrangement	7 years
Options to extend number of terms \| option	2
Optional extended lease term	7 years
Sale leaseback transaction, net proceeds	$ 21,900,000
Sale leaseback transaction, net carrying value	20,500,000
Sale of assets to an entity under common control	$ 1,400,000

Financial Statement Details - Convertible note receivable (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2016
Financial Statement Details [Line Items]
Convertible note receivable	$ 6,379	$ 6,129
Interest receivable	$ 1,400	$ 1,100
Riptide Bioscience, Inc.
Financial Statement Details [Line Items]
Convertible note receivable			$ 5,000
Interest rate	5.00%
Milestone payment, payable amount	$ 47,000
Riptide Bioscience, Inc. \| Maximum
Financial Statement Details [Line Items]
Milestone payment, amount	$ 100,000

Financial Statement Details - Accrued Expenses and Other Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Accrued Liabilities, Current [Abstract]
Accrued dissenting shares (Note 7)	$ 7,118	$ 6,769
Accrued bonus	8,316	5,288
Accrued construction costs	8,145	0
Accrued preclinical and clinical trial costs	5,842	4,339
Accrued professional and service fees	6,909	7,668
Accrued compensation	5,613	3,891
Other	9,444	8,816
Accrued expenses and other liabilities	$ 51,387	$ 36,771

Financial Statement Details - Interest and Investment (Loss) Income, Net (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Investment Income, Net [Abstract]
Unrealized (losses) gains from equity securities	$ (4,615)	$ 1,577	$ (321)
Interest income	836	1,725	2,764
Investment (amortization expense) accretion income, net	(488)	(858)	3
Net realized gains (losses) on investments	167	(9)	(4)
Interest and investment (loss) income, net	$ (4,100)	$ 2,435	$ 2,442

Financial Instruments - Summary of Available-for-Sale Marketable Debt Securities (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	$ 130,060	$ 55,685
Gross Unrealized Gains	116	93
Gross Unrealized Losses	(37)	(19)
Fair Value	130,139	55,759
Current Assets
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	129,341	54,824
Gross Unrealized Gains	13	4
Gross Unrealized Losses	(37)	(19)
Fair Value	$ 129,317	54,809
Current Assets \| Foreign bonds
Schedule Of Available For Sale Securities [Line Items]
Weighted- Average Remaining Contractual Life (in years)	4 months 24 days
Amortized Cost	$ 116
Gross Unrealized Gains	0
Gross Unrealized Losses	(1)
Fair Value	$ 115
Current Assets \| Corporate debt securities
Schedule Of Available For Sale Securities [Line Items]
Weighted- Average Remaining Contractual Life (in years)	6 months
Amortized Cost	$ 129,190	54,789
Gross Unrealized Gains	10	2
Gross Unrealized Losses	(36)	(19)
Fair Value	129,164	54,772
Current Assets \| Mutual funds
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	35	35
Gross Unrealized Gains	3	2
Gross Unrealized Losses	0	0
Fair Value	38	37
Noncurrent Assets
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	719	861
Gross Unrealized Gains	103	89
Gross Unrealized Losses	0	0
Fair Value	$ 822	950
Noncurrent Assets \| Foreign bonds
Schedule Of Available For Sale Securities [Line Items]
Weighted- Average Remaining Contractual Life (in years)	5 years
Amortized Cost	$ 719	861
Gross Unrealized Gains	103	89
Gross Unrealized Losses	0	0
Fair Value	$ 822	$ 950

Financial Instruments - Accumulated Unrealized Losses on Debt Securities Classified as Available-for-Sale in Continuous Loss Position (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Schedule Of Available For Sale Securities [Line Items]
Less than 12 months, Estimated Fair Value	$ 86,273	$ 42,762
Less than 12 months, Gross Unrealized Losses	(37)	(19)
More than 12 months, Estimated Fair Value	147	0
More than 12 months, Gross Unrealized Losses	(3)	0
Foreign bonds
Schedule Of Available For Sale Securities [Line Items]
Less than 12 months, Estimated Fair Value	115
Less than 12 months, Gross Unrealized Losses	(1)
More than 12 months, Estimated Fair Value	113
More than 12 months, Gross Unrealized Losses	(1)
Corporate debt securities
Schedule Of Available For Sale Securities [Line Items]
Less than 12 months, Estimated Fair Value	86,158	42,762
Less than 12 months, Gross Unrealized Losses	(36)	(19)
More than 12 months, Estimated Fair Value	0	0
More than 12 months, Gross Unrealized Losses	0	$ 0
Mutual funds
Schedule Of Available For Sale Securities [Line Items]
Less than 12 months, Estimated Fair Value	0
Less than 12 months, Gross Unrealized Losses	0
More than 12 months, Estimated Fair Value	34
More than 12 months, Gross Unrealized Losses	$ (2)

Financial Instruments - Additional Information (Detail) - USD ($)		3 Months Ended	12 Months Ended
	Feb. 25, 2021	Mar. 31, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	May 31, 2019	Dec. 31, 2018	Mar. 31, 2017
Schedule Of Available For Sale Securities [Line Items]
Other than temporary impairment losses			$ 0	$ 0	$ 0
Unrealized gains (losses) on equity securities			(4,615,000)	2,876,000	(320,000)
Non-marketable equity investment			0	7,800,000
Fair value of equity investment			5,700,000
Sunesis Pharmaceuticals, Inc. \| Common Stock
Schedule Of Available For Sale Securities [Line Items]
Preferred stock investment converted into common stock (in shares)	1,562,604
Viracta Therapeutics, Inc.
Schedule Of Available For Sale Securities [Line Items]
Unrealized gains (losses) on equity securities				(1,400,000)
Non-marketable equity investment				7,800,000			$ 700,000	$ 8,500,000
Increase in investment upon conversion		$ 800,000
Shares of common stock acquired (in shares)						253,120
Equity securities
Schedule Of Available For Sale Securities [Line Items]
Investments in marketable equity securities with readily determinable fair values			6,700,000	6,300,000
Unrealized gains (losses) on equity securities			(4,600,000)	1,600,000	(300,000)
Realized gains on sales of equity securities			200,000
Debt Securities
Schedule Of Available For Sale Securities [Line Items]
Other than temporary impairment losses			$ 0	$ 0	$ 0

Fair Value Measurements - Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis - Narrative (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Non-marketable equity investment	$ 0	$ 7,800
Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	317,938	97,011
Current Assets \| Fair Value, Measurements, Recurring \| Equity securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	5,700	6,337
Current Assets \| Cash and cash equivalents \| Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	181,101	$ 34,915
Current Assets \| Corporate debt securities \| Cash and cash equivalents \| Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	54,200
Current Assets \| Government-sponsored securities \| Cash and cash equivalents \| Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	75,000
Current Assets \| Commercial Paper \| Cash and cash equivalents \| Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	$ 500

Fair Value Measurements - Summary of Changes in Carrying Amount of Contingent Consideration (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Roll Forward]
Fair value, beginning of year	$ (972)	$ (1,725)	$ (1,004)
Consideration paid	419	0	(786)
Net decrease in fair value	144	753	65
Fair value, end of year	$ (409)	$ (972)	$ (1,725)

Collaboration and License Agreements - Collaboration Agreements - Additional Information (Detail) - USD ($) $ in Thousands			1 Months Ended	12 Months Ended
	Nov. 12, 2021	Feb. 22, 2021	Jan. 31, 2018	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Research and Development Arrangements with Federal Government [Line Items]
Loss on equity method investment				$ 803	$ 0	$ 0
AccessBio, LLC
Research and Development Arrangements with Federal Government [Line Items]
Advances to support operations				1,000
Value of joint venture				$ 9,000
Percentage of ownership interest				50.00%
Loss on equity method investment				$ 800
National Cancer Institute (NCI) \| 2015 CRADA
Research and Development Arrangements with Federal Government [Line Items]
Annual payment for support of research activities			$ 600
Payment for support of research activities				600	600
National Cancer Institute (NCI) \| 2015 CRADA \| Research and Development
Research and Development Arrangements with Federal Government [Line Items]
Payment for support of research activities				600	$ 600
National Cancer Institute (NCI) \| 2015 CRADA, Amendment
Research and Development Arrangements with Federal Government [Line Items]
Annual project funding amount	$ 1,300
Payable related for support of research activities, additional	$ 700
National Cancer Institute (NCI) \| 2015 CRADA, Amendment \| Research and Development
Research and Development Arrangements with Federal Government [Line Items]
Payment for support of research activities				500
National Institute of Deafness and Communication Disorders (NIDCD) \| 2021 CRADA
Research and Development Arrangements with Federal Government [Line Items]
Annual payment for support of research activities		$ 100
Payment for support of research activities				$ 100

Collaboration and License Agreements - License Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended	12 Months Ended
	Sep. 30, 2021	May 31, 2021	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2017
Licensing Agreement [Line Items]
Research and development expense			$ 41,128,000	$ 195,958,000	$ 139,507,000	$ 111,997,000
Infectious Disease Research Institute
Licensing Agreement [Line Items]
Non-refundable upfront cash payments		$ 2,000,000
Milestone payment, payable amount		$ 2,500,000
Milestone fees				0
Infectious Disease Research Institute \| Sponsored Research Agreement
Licensing Agreement [Line Items]
Research and development expense				1,200,000
Infectious Disease Research Institute \| Sponsored Research Agreement \| Minimum
Licensing Agreement [Line Items]
Annual payment for support of research activities				2,000,000
Infectious Disease Research Institute \| Research and Development
Licensing Agreement [Line Items]
Non-refundable upfront cash payments				2,000,000
Infectious Disease Research Institute, Amended and Restated Agreement \| License Agreement Terms
Licensing Agreement [Line Items]
Non-refundable upfront cash payments	$ 1,500,000
Termination fee				10,000,000
Milestone payment, amount				4,000,000
Research and development expense				1,500,000
Infectious Disease Research Institute, Amended and Restated Agreement \| License Agreement Terms \| 2022
Licensing Agreement [Line Items]
License maintenance fees				3,000,000
Infectious Disease Research Institute, Amended and Restated Agreement \| License Agreement Terms \| 2023 through 2030
Licensing Agreement [Line Items]
License maintenance fees				$ 5,500,000
Viracta \| License Agreement
Licensing Agreement [Line Items]
Milestone payment, aggregate maximum							$ 100,000,000
Viracta \| License Agreement \| Minimum
Licensing Agreement [Line Items]
Milestone payment, amount							10,000,000
Viracta \| License Agreement \| Maximum
Licensing Agreement [Line Items]
Milestone payment, amount							$ 25,000,000

Commitment and Contingencies - Contingent Consideration Related to Business Combinations - Additional Information (Detail) - USD ($) $ in Millions		1 Months Ended	3 Months Ended	12 Months Ended
	Jun. 15, 2015	Apr. 30, 2015	Dec. 31, 2021	Dec. 31, 2021
Business Acquisition [Line Items]
Ownership percentage acquired		100.00%
Business combination, consideration transferred		$ 0.7
Maximum milestone payment due if certain conditions are met	$ 2.3
Contingent consideration arrangements, earned			$ 0.8
Contingent consideration arrangements, paid			0.4
Contingent consideration arrangements, payable			0.4	$ 0.4
Altor BioScience Corporation \| Dr. Soon-Shiong and Related Party
Business Acquisition [Line Items]
Contingent value rights payable			279.5	279.5
Altor BioScience Corporation \| Contingent Value Rights Payable, Regulatory Milestone
Business Acquisition [Line Items]
Contingent value rights payable			304.0	304.0
Altor BioScience Corporation \| Contingent Value Rights Payable, Regulatory Milestone \| Altor Stockholders
Business Acquisition [Line Items]
Contingent value rights payable			164.2	164.2
Altor BioScience Corporation \| Contingent Value Rights Payable, Sales Milestone
Business Acquisition [Line Items]
Contingent value rights payable			304.0	304.0
Minimum net sales milestone for contingent value rights payable				1,000.0
Altor BioScience Corporation \| Contingent Value Rights Payable, Sales Milestone \| Altor Stockholders
Business Acquisition [Line Items]
Contingent value rights payable			$ 164.2	$ 164.2

Commitment and Contingencies - Litigation - Additional Information (Detail) - USD ($) $ in Thousands				12 Months Ended					48 Months Ended
	Aug. 09, 2019	Jul. 20, 2019	May 31, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2015	Dec. 31, 2018
Litigation [Line Items]
Legal fees	$ 500
Payment to Precision Biologics to facilitate deconsolidation				$ 0	$ 0	$ 2,500
Precision Biologics, Inc.
Litigation [Line Items]
Cash invested in affiliate								$ 50,000
Investment in affiliate (in shares)								41,000,000
Cash divested from deconsolidation		$ 29,300
Payment to Precision Biologics to facilitate deconsolidation		$ 2,500
Loss associated with deconsolidation									$ 20,200
Sudunagunta v. NantKwest, Inc.
Litigation [Line Items]
Amount awarded to other party in litigation settlement			$ 12,000
Insurance recovery							$ 10,800
Selling General and Administrative Expense \| Precision Biologics, Inc.
Litigation [Line Items]
Loss associated with deconsolidation						$ 900
Selling General and Administrative Expense \| Sudunagunta v. NantKwest, Inc.
Litigation [Line Items]
Payment for legal settlement							$ 1,200
Altor BioScience, LLC
Litigation [Line Items]
Accrual for dissenting shares				$ 7,100	$ 6,800

Commitment and Contingencies - Lease Arrangements - Additional Information (Detail) $ in Millions	1 Months Ended	12 Months Ended
	Sep. 30, 2021 option	Dec. 31, 2021 USD ($)
Lessee Lease Description [Line Items]
Operating lease payments related to options to extend lease terms \| $		$ 24.1
557 South Douglas Street
Lessee Lease Description [Line Items]
Optional extended lease term	7 years
557 South Douglas Street \| Nant Capital
Lessee Lease Description [Line Items]
Initial term of lease arrangement	7 years
Options to extend number of terms \| option	2
Optional extended lease term	7 years
Minimum
Lessee Lease Description [Line Items]
Initial term of lease arrangement		2 years
Optional extended lease term		1 year
Maximum
Lessee Lease Description [Line Items]
Initial term of lease arrangement		10 years
Optional extended lease term		7 years

Commitment and Contingencies - Summary of Information Regarding Leases (Detail)	Dec. 31, 2021	Dec. 31, 2020
Leases [Abstract]
Weighted average remaining lease term	7 years 9 months 18 days	3 years 10 months 24 days
Weighted average discount rate	9.60%	9.00%

Commitment and Contingencies - Components of Lease Expense (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Lease, Cost [Abstract]
Operating lease costs	$ 7,977	$ 5,668	$ 5,795
Variable lease costs	2,862	3,564	2,764
Total lease costs	$ 10,839	$ 9,232	$ 8,559

Commitment and Contingencies - Schedule of Cash Paid for Amounts Included in Measurement of Lease Liabilities (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Cash Flow Operating Activities Lessee [Abstract]
Cash paid for operating leases (excluding variable lease costs)	$ 9,034	$ 7,843	$ 7,571

Commitment and Contingencies - Summary of Future Minimum Lease Payments (Detail) $ in Thousands	Dec. 31, 2021 USD ($)
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
2022	$ 8,962
2023	8,316
2024	7,768
2025	7,214
2026	5,259
Thereafter	26,098
Total future minimum lease payments	63,617
Less: Interest	20,597
Less: Tenant improvement allowance receivable	2,941
Present value of operating lease liabilities	$ 40,079

Commitments and Contingencies - Unconditional Purchase Obligations (Details) $ in Millions	Dec. 31, 2021 USD ($)
cGMP Batches
Long-term Purchase Commitment [Line Items]
Non-cancelable purchase commitments, 2022	$ 3.5
Non-cancelable purchase commitments, 2023	3.5
Software License Subscription Fees
Long-term Purchase Commitment [Line Items]
Unconditional purchase obligation commitment	2.6
Unconditional purchase obligation commitment, 2022	2.1
Unconditional purchase obligation commitment, 2023	$ 0.5

Related-Party Agreements - Summary of Outstanding Balances of Related-Party Agreements (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Related Party Transaction [Line Items]
Total due from related parties	$ 1,333	$ 2,003
Total due to related parties	3,943	14,838
NantBio, Inc.
Related Party Transaction [Line Items]
Total due from related parties	1,294	1,294
Total due to related parties	943	943
NantOmics LLC
Related Party Transaction [Line Items]
Total due from related parties	0	591
NantWorks
Related Party Transaction [Line Items]
Total due to related parties	1,113	10,650
Duley Road, LLC
Related Party Transaction [Line Items]
Total due to related parties	1,380	2,787
605 Nash, LLC
Related Party Transaction [Line Items]
Total due to related parties	0	0
Immuno-Oncology Clinic, Inc.
Related Party Transaction [Line Items]
Total due to related parties	507	271
Various
Related Party Transaction [Line Items]
Total due from related parties	39	118
Total due to related parties	$ 0	$ 187

Related-Party Agreements - Additional Information (Detail)						1 Months Ended									3 Months Ended		12 Months Ended
	Nov. 12, 2021 USD ($)	Oct. 01, 2021 USD ($) ft² Term	Sep. 27, 2021 USD ($) ft²	Apr. 01, 2021 USD ($) ft²	Jan. 01, 2021 USD ($) ft² Term	Sep. 30, 2021 USD ($) option	Oct. 31, 2019 USD ($)	Jul. 31, 2019 USD ($)	Jan. 31, 2019 USD ($) Term	Aug. 31, 2018	Feb. 28, 2017 USD ($) ft² Term	Sep. 30, 2016 USD ($) ft² Term	Mar. 31, 2016 USD ($)	Nov. 30, 2015 USD ($) ft²	Jun. 30, 2021 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($) lease	Jan. 01, 2019 ft²
Related Party Transaction [Line Items]
Selling, general and administrative expense																$ 45,275,000	$ 135,256,000	$ 71,318,000	$ 46,456,000
Research and development expense																$ 41,128,000	195,958,000	139,507,000	111,997,000
Due to related parties																	3,943,000	14,838,000
Sale leaseback transaction, capital contribution																	1,435,000	0	0
Future minimum lease payments																	$ 63,617,000
Maximum
Related Party Transaction [Line Items]
Initial term of lease arrangement																	10 years
Brink Biologics, Inc.
Related Party Transaction [Line Items]
Revenue from related parties																	$ 400,000
NantBio, Inc.
Related Party Transaction [Line Items]
Due from related parties																	1,300,000	1,300,000
420 Nash, LLC
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²		19,125
Base rent - monthly		$ 38,250
Percentage of annual increases of base rent		3.00%
Optional extended lease term		5 years
Options to extend number of terms \| Term		2
Tenant improvements incentive		$ 15,000
Research and Development \| 420 Nash, LLC
Related Party Transaction [Line Items]
Lease expense																	100,000
Employee Bonuses Payment \| NantBio, Inc.
Related Party Transaction [Line Items]
Due from related parties																	1,000,000	1,000,000
Employee Bonuses Payment \| NantOmics LLC
Related Party Transaction [Line Items]
Due from related parties																	0	600,000
Vendor Costs Payments \| NantBio, Inc.
Related Party Transaction [Line Items]
Due from related parties																	300,000	300,000
2015 CRADA, Amendment \| National Cancer Institute (NCI)
Related Party Transaction [Line Items]
Payable related for support of research activities, additional	$ 700,000
NantWorks
Related Party Transaction [Line Items]
Due to related parties																	1,113,000	10,650,000
Number of square foot of facility leased \| ft²														9,500
Base rent - monthly														$ 47,000
Percentage of annual increases of base rent														3.00%
NantWorks \| Amendment to Extend Lease Term
Related Party Transaction [Line Items]
Base rent - monthly					$ 54,500
Percentage of annual increases of base rent					3.00%
Lease expense																	700,000	600,000	600,000
NantWorks \| Shared Services Agreement
Related Party Transaction [Line Items]
Selling, general and administrative expense																	4,400,000	6,000,000	6,800,000
Prepaid expenses																	2,200,000	1,000,000
NantWorks \| Shared Services Agreement \| Reimbursements
Related Party Transaction [Line Items]
Research and development expense																	400,000	2,000,000	1,500,000
Due to related parties																	1,100,000	10,700,000
Immuno-Oncology Clinic, Inc.
Related Party Transaction [Line Items]
Research and development expense																	1,600,000	900,000	1,100,000
Due to related parties																	500,000	300,000
Prepaid expenses																		4,700,000
Related party transaction installment payment							$ 1,900,000	$ 3,800,000
Related party transaction conditional payment							$ 1,900,000	1,900,000
Immuno-Oncology Clinic, Inc. \| Maximum
Related Party Transaction [Line Items]
Maximum payment due under contract								$ 7,500,000
Immuno-Oncology Clinic, Inc. \| Research and Development
Related Party Transaction [Line Items]
Partial write down of prepaid expense															$ 1,900,000		2,500,000
NantBio, Inc.
Related Party Transaction [Line Items]
Research and development expense																	500,000
Due to related parties																	943,000	943,000
Annual amount due under contract													$ 600,000
NCSC
Related Party Transaction [Line Items]
Due to related parties																	900,000	900,000
Initial term of lease arrangement										5 years
Optional extended lease term										1 year
Revenue recognized																	300,000
Deferred revenue																	100,000	300,000
605 Doug St, LLC
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²												24,250
Base rent - monthly												$ 72,385
Percentage of annual increases of base rent												3.00%
Optional extended lease term												3 years
Options to extend number of terms \| Term												1
605 Doug St, LLC \| Research and Development
Related Party Transaction [Line Items]
Lease expense																	900,000	900,000	$ 900,000
Duley Road, LLC
Related Party Transaction [Line Items]
Base rent - monthly									$ 35,800
Percentage of annual increases of base rent									3.00%
Optional extended lease term									5 years
Options to extend number of terms \| Term									2
Number of leases \| lease																			2
Duley Road, LLC \| Altor BioScience Corporation
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²											12,000
Base rent - monthly											$ 40,700
Percentage of annual increases of base rent											3.00%
Lease expense																	400,000	300,000
Optional extended lease term											5 years
Options to extend number of terms \| Term											2
Duley Road, LLC \| Altor BioScience Corporation \| Due to Related Parties
Related Party Transaction [Line Items]
Rent payable																	200,000	1,300,000
Leasehold improvement payables																	900,000	900,000
Lease-related payables																	300,000	600,000
Duley Road, LLC \| Research and Development \| Altor BioScience Corporation
Related Party Transaction [Line Items]
Lease expense																	600,000	500,000
Duley Road, LLC \| September 2019 Lease
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²																				5,650
Initial term of lease arrangement																				7 years
Duley Road, LLC \| July 2019 Lease
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²																				6,488
Initial term of lease arrangement																				7 years
605 Nash, LLC
Related Party Transaction [Line Items]
Due to related parties																	0	$ 0
605 Nash, LLC \| Initial Premises
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²					6,883
Base rent - monthly					$ 20,300
Percentage of annual increases of base rent					3.00%
Optional extended lease term					3 years
Options to extend number of terms \| Term					1
Rent abatement period					7 months
Tenant improvements incentive					$ 300,000
605 Nash, LLC \| Initial Premises \| Research and Development
Related Party Transaction [Line Items]
Lease expense																	200,000
605 Nash, LLC \| Expansion Premises
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²				57,760
Base rent - monthly				$ 170,400
Percentage of annual increases of base rent				3.00%
Optional extended lease term				3 years
Rent abatement period				7 months
Tenant improvements incentive				$ 2,600,000
605 Nash, LLC \| Expansion Premises \| Research and Development
Related Party Transaction [Line Items]
Lease expense																	1,500,000
557 Doug St, LLC
Related Party Transaction [Line Items]
Number of square foot of facility leased \| ft²			36,434
Base rent - monthly						$ 81,976
Percentage of annual increases of base rent						3.00%
Optional extended lease term						7 years
Period of rent free lease term						2 years
Prepayment of first month rent and security deposit																	200,000
557 Doug St, LLC \| Nant Capital
Related Party Transaction [Line Items]
Initial term of lease arrangement						7 years
Optional extended lease term						7 years
Options to extend number of terms \| option						2
Sale-leaseback transaction, consideration transferred			$ 22,000,000
Sale-leaseback transaction, property taxes			100,000
Sale leaseback transaction, net proceeds						$ 21,900,000
Sale leaseback transaction, independent appraisal value			$ 22,000,000
Sale leaseback transaction, net carrying value						20,500,000
Sale leaseback transaction, capital contribution						$ 1,400,000
557 Doug St, LLC \| Research and Development
Related Party Transaction [Line Items]
Lease expense																	$ 300,000

Related-Party Agreements - Summary of Related-Party Notes Payable (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Related Party Transaction [Line Items]
Outstanding Advances	$ 576,644
Total Notes and Interest Payable as of December 31,	605,585	$ 254,353
Nant Capital
Related Party Transaction [Line Items]
Outstanding Advances	$ 300,000
Interest Rate	5.47%
Total Notes and Interest Payable as of December 31,	$ 299,236	0
Option to convert accrued and unpaid interest to shares of common stock (in dollars per share)	$ 5.67
Nant Capital \| SOFR
Related Party Transaction [Line Items]
Interest Rate, basis spread on variable rate	5.40%
Nant Capital
Related Party Transaction [Line Items]
Outstanding Advances	$ 55,226
Interest Rate	5.00%
Total Notes and Interest Payable as of December 31,	$ 61,367	58,482
Nant Capital
Related Party Transaction [Line Items]
Outstanding Advances	$ 50,000
Interest Rate	6.00%
Total Notes and Interest Payable as of December 31,	$ 53,810	50,764
Nant Capital
Related Party Transaction [Line Items]
Outstanding Advances	$ 40,000
Interest Rate	6.00%
Total Notes and Interest Payable as of December 31,	$ 40,000	0
NantMobile
Related Party Transaction [Line Items]
Outstanding Advances	$ 55,000
Interest Rate	3.00%
Total Notes and Interest Payable as of December 31,	$ 58,359	56,660
NantWorks
Related Party Transaction [Line Items]
Outstanding Advances	$ 43,418
Interest Rate	5.00%
Total Notes and Interest Payable as of December 31,	$ 54,067	51,546
NCSC
Related Party Transaction [Line Items]
Outstanding Advances	$ 33,000
Interest Rate	5.00%
Total Notes and Interest Payable as of December 31,	$ 38,746	$ 36,901

Related-Party Agreements - Summary of Related-Party Notes Payable Narrative (Detail) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	$ 29.7
Nant Capital
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	0.7
Payments of debt issuance costs	1.5
Nant Capital
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	6.1	$ 3.3
Nant Capital
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	3.8	0.8
Nant Capital
Related Party Transaction [Line Items]
Related party interest paid	2.0
NantMobile
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	3.4	1.7
NantWorks
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	10.6	8.1
NCSC
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	$ 5.7	$ 3.9

Related-Party Agreements - Estimated Material Contractual Obligations Related to Related-Party Notes Payable (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)
Related Party Transaction [Line Items]
Accrued and unpaid interest on note	$ 29,700
Outstanding Advances	$ 576,644
Nant Capital
Related Party Transaction [Line Items]
Interest Rate	5.47%
Accrued and unpaid interest on note	$ 700
Outstanding Advances	$ 300,000
Nant Capital
Related Party Transaction [Line Items]
Interest Rate	6.00%
Outstanding Advances	$ 40,000
Affiliated Entity \| Related Party Notes
Related Party Transaction [Line Items]
2022	318,808
2023	2,400
2024	2,407
2025	362,467
Total principal and estimated interest due on related-party notes	686,082
Affiliated Entity \| Principal Payments
Related Party Transaction [Line Items]
2022	300,000
2023	0
2024	0
2025	276,644
Total principal and estimated interest due on related-party notes	576,644
Affiliated Entity \| Interest Payments
Related Party Transaction [Line Items]
2022	18,808
2023	2,400
2024	2,407
2025	85,823
Total principal and estimated interest due on related-party notes	$ 109,438

Stockholders' Deficit - Additional Information (Detail)			12 Months Ended			84 Months Ended
Stockholders' Deficit - Additional Information (Detail)	Apr. 30, 2021 USD ($)	Mar. 09, 2021 $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2019 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Feb. 01, 2022 $ / shares shares
Class Of Stock [Line Items]
Common stock, shares authorized (in shares)			500,000,000	500,000,000		500,000,000
Common stock, par value (in dollars per share) \| $ / shares		$ 0.0001	$ 0.0001	$ 0.0001		$ 0.0001
Preferred stock, shares authorized (in shares)			20,000,000			20,000,000
Preferred stock, par value (in dollars per share) \| $ / shares			$ 0.0001			$ 0.0001
Common stock, shares issued (in shares)			397,830,044	382,243,142		397,830,044
Common stock, shares outstanding (in shares)			397,830,044	382,243,142		397,830,044
Treasury stock, shares outstanding (in shares)			163,800	163,800		163,800
Proceeds from equity offering, net of issuance costs paid \| $			$ 164,530,000	$ 86,302,000	$ 30,000,000
Issuance of shares under ATM (in shares)			13,295,817
Sale of stock issued in transaction (in dollars per share) \| $ / shares				$ 9.50
Subsequent Event
Class Of Stock [Line Items]
Common stock, shares authorized (in shares)							900,000,000
Common stock, par value (in dollars per share) \| $ / shares							$ 0.0001
Public Stock Offering
Class Of Stock [Line Items]
Sale of stock issued in transaction (in shares)				8,521,500
Sales of stock issued in transaction \| $				$ 90,700,000
Stock issuance costs \| $				$ 4,373,000
Public Stock Offering - Shares Issued to the Public
Class Of Stock [Line Items]
Sale of stock issued in transaction (in shares)				4,811,500
Public Stock Offering - Shares Issued to Executive
Class Of Stock [Line Items]
Sale of stock issued in transaction (in shares)				3,710,000
Sale of stock issued in transaction (in dollars per share) \| $ / shares				$ 12.12
Over-Allotment Option
Class Of Stock [Line Items]
Sale of stock issued in transaction (in shares)				1,111,500
Private Placement
Class Of Stock [Line Items]
Sale of stock issued in transaction (in shares)					2,047,500
Sale of stock issued in transaction (in dollars per share) \| $ / shares					$ 14.66
Sales of stock issued in transaction \| $					$ 30,000,000
ATM Offering Program
Class Of Stock [Line Items]
Proceeds from equity offering, net of issuance costs paid \| $			$ 164,500,000
Available for future stock issuance \| $			330,800,000			$ 330,800,000
ATM Offering Program \| Maximum
Class Of Stock [Line Items]
Maximum aggregate offering price \| $	$ 500,000,000
Percentage of sales agent commission	3.00%
2015 Share Repurchase Plan
Class Of Stock [Line Items]
Stock repurchase program, authorized amount \| $			$ 50,000,000			$ 50,000,000
Repurchase of common stock, shares (in shares)			0	0	473,586	6,403,489
Repurchase of common stock, value \| $					$ 500,000	$ 31,700,000
Remaining authorized repurchase amount \| $			$ 18,300,000			$ 18,300,000
Stock Transfer Agreement
Class Of Stock [Line Items]
Repurchase of common stock, shares (in shares)					204,750
Repurchase of common stock, value \| $					$ 2,000,000
Stock repurchased (in dollars per share) \| $ / shares					$ 9.77
NantCell
Class Of Stock [Line Items]
Common stock, par value (in dollars per share) \| $ / shares		$ 0.001
Merger exchange ratio		0.8190
Shares issued (in shares)		273,700,000

Stock-Based Compensation - Additional Information (Detail) $ / shares in Units, $ in Thousands								12 Months Ended
	Jun. 10, 2021 $ / shares shares	May 03, 2021 installment $ / shares shares	Mar. 29, 2021 USD ($) director shares	Mar. 18, 2021 USD ($)	Mar. 09, 2021 shares	Mar. 04, 2021 shares	Feb. 05, 2021 Award $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) shares	Dec. 31, 2019 USD ($)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $								$ 57,181	$ 2,187	$ 3,421
Granted (in shares)								1,069,940
Granted (in dollars per share) \| $ / shares								$ 21.38
Proceeds from stock options exercised \| $								$ 5,461	$ 1,176	4,086
Vested and exercisable (in shares)								3,038,322	4,345,497
Research and Development Expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $								$ 18,819	$ 261	1,288
Selling General and Administrative Expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $								38,362	1,926	2,133
Modification of Stock Options Associated with Postponement of Termination Date
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $				$ 2,700
Modification of Stock Options Associated with Resignation
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of board of directors resignation \| director			2
Modified options exercisable period			90 days
Non-employee Director \| Modification of Stock Options Associated with Resignation
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $			$ 2,300
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized compensation cost related to unvested stock options \| $								$ 11,800
Weighted-average period for recognition								2 years
Aggregate intrinsic value of stock option exercised \| $								$ 21,300
Proceeds from stock options exercised \| $								$ 5,400
Stock Options \| First Anniversary
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested number of shares (in shares)							250,000
Vesting rights, percentage							33.00%
Stock Options \| Second Anniversary
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested number of shares (in shares)							250,000
Vesting rights, percentage							33.00%
Stock Options \| Thrid Anniversary
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested number of shares (in shares)							250,000
Vesting rights, percentage							33.00%
Stock Options \| Modification of Stock Options Associated with Resignation
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested number of shares (in shares)			83,333
Stock Options \| Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of vesting installments \| installment		3
Stock Options \| Chairman and Board of Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting rights, percentage	100.00%
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested number of shares (in shares)							83,333
Grants of restricted stock (in units)								8,665,942
Stock-based compensation expense \| $								$ 45,558	$ 761	$ 1,368
Weighted-average period for recognition								3 years 6 months
Unrecognized compensation cost related to non-vested stock options \| $								$ 112,100
Aggregate intrinsic value, vested \| $								12,200
Estimated benefit at grant date fair value \| $								4,000
Deemed dividends \| $								$ 900
Restricted Stock Units \| First Anniversary
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting rights, percentage							33.00%
Restricted Stock Units \| Second Anniversary
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting rights, percentage							33.00%
Restricted Stock Units \| Thrid Anniversary
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting rights, percentage							33.00%
Warrants
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of warrants outstanding (in shares)								1,638,000
Exercise price of warrants (in dollars per share) \| $ / shares								$ 3.24
Fair value of warrants \| $								$ 18,000
2014 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested number of shares (in shares)								503,493
2015 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for future grants								5,000,000
Number of awards granted \| Award							2
2015 Equity Incentive Plan \| Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)							750,000
Granted (in dollars per share) \| $ / shares							$ 23.72
2015 Equity Incentive Plan \| Stock Options \| Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)		21,873
Granted (in dollars per share) \| $ / shares		$ 17.24
2015 Equity Incentive Plan \| Stock Options \| Chairman and Board of Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)	26,064
Granted (in dollars per share) \| $ / shares	$ 14.91
2015 Equity Incentive Plan \| Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Grants of restricted stock (in units)							400,000
First RSU Award \| Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued (in shares)							150,000
Second RSU Award \| Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued (in shares)							250,000
NantCell
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Merger exchange ratio					0.8190
Shares issued (in shares)					273,700,000
NantCell \| Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $								$ 40,500
NantCell \| Restricted Stock Units \| Research and Development Expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $								18,900
NantCell \| Restricted Stock Units \| Selling General and Administrative Expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense \| $								$ 21,600
NantCell \| Restricted Stock Units \| Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, award requisite service period								6 months
NantCell \| Restricted Stock Units \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, award requisite service period								70 months
NantCell \| NC 2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Grants of restricted stock (in units)						7,121,110

Stock-Based Compensation - Stock-Based Compensation Expenses Related to Statement of Operations (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	$ 57,181	$ 2,187	$ 3,421
Research and Development
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	18,819	261	1,288
Selling, general and administrative
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	38,362	1,926	2,133
Stock options
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	11,623	1,426	2,053
RSUs
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	$ 45,558	$ 761	$ 1,368

Stock-Based Compensation - Stock Option Activity and Related Information under Equity Plans (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Number of Options
Outstanding, beginning balance (in shares)	4,996,284
Granted (in shares)	1,069,940
Exercised (in shares)	(1,817,300)
Expired/forfeited (in shares)	(123,994)
Outstanding, ending balance (in shares)	4,124,930	4,996,284
Vested and exercisable (in shares)	3,038,322	4,345,497
Weighted-Average Exercise Price
Outstanding, beginning balance (in dollars per share)	$ 9.96
Granted (in dollars per share)	21.38
Exercised (in dollars per share)	3.95
Expired/forfeited (in dollars per share)	10.10
Outstanding, ending balance (in dollars per share)	15.62	$ 9.96
Vested and exercisable (in dollars per share)	$ 13.89
Aggregate Intrinsic Value
Outstanding, beginning balance	$ 29,746
Outstanding, ending balance	4,178	$ 29,746
Vested and exercisable	$ 3,978
Weighted- Average Remaining Contractual Life (in years)
Outstanding	5 years 3 months 18 days	4 years 8 months 12 days
Vested and exercisable	3 years 10 months 24 days

Stock-Based Compensation - Weighted Average Fair Value of Options Under Black-Scholes Option Pricing Model (Detail) - Stock Options - $ / shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected life (in years)	5 years 10 months 24 days	5 years 6 months
Risk-free interest rate	0.70%	0.40%
Volatility factor	101.00%	96.80%
Dividend yield	0.00%	0.00%
Weighted-average grant date fair value (in dollars per share)	$ 16.80	$ 4.64

Stock-Based Compensation - RSU Activity under Equity Plans (Detail) - RSUs	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Number of Units
Nonvested, beginning balance (in units) \| shares	466,842
Granted (in units) \| shares	8,665,942
Vested (in units) \| shares	(873,058)
Forfeited/canceled (in units) \| shares	(1,743,837)
Nonvested, ending balance (in units) \| shares	6,515,889
Weighted- Average Grant Date Fair Value
Nonvested, beginning balance (in dollars per share) \| $ / shares	$ 2.52
Granted (in dollars per share) \| $ / shares	23.27
Vested (in dollars per share) \| $ / shares	19.61
Forfeited/canceled (in dollars per share) \| $ / shares	24.77
Nonvested, ending balance (in dollars per share) \| $ / shares	$ 21.88

Income Taxes - Loss Before Taxes, Domestic and Foreign (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
U.S. loss before taxes	$ (347,226)	$ (223,519)	$ (159,089)
Foreign loss before taxes	(2,613)	(2,514)	(1,174)
Loss before income taxes and noncontrolling interests	$ (349,839)	$ (226,033)	$ (160,263)

- Definition

Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8933-108599

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8906-108599

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (f)
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8933-108599

Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 940
-SubTopic 20
-Section 25
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=123384075&loc=d3e41242-110953

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8736-108599

Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(10))
-URI http://asc.fasb.org/extlink&oid=123367319&loc=SL114868664-224227

Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(8))
-URI http://asc.fasb.org/extlink&oid=120400993&loc=SL114874131-224263

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 235
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-05(b)(2))
-URI http://asc.fasb.org/extlink&oid=120399901&loc=d3e537907-122884

Reference 9: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 31
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8924-108599

Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(15))
-URI http://asc.fasb.org/extlink&oid=120399700&loc=SL114874048-224260

+ Details

Income Taxes - Components of Income Tax Benefit (Provision) (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Current:
Federal		$ 0	$ 0	$ 0
State		(9)	(5)	(3)
Foreign		0	0	0
Total current		(9)	(5)	(3)
Deferred:
Federal		0	1,187	77
State		0	664	31
Foreign		0	0	0
Total deferred		0	(1,851)	(108)
Total income tax (expense) benefit	$ (6)	$ (9)	$ 1,846	$ 105

Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating loss carryforwards	$ 314,612	$ 223,123
Stock-based compensation	23,116	13,305
Research and development credits	17,716	21
Operating lease liabilities	10,316	5,456
Interest expense	8,531	5,055
Amortization	4,407	5,860
Depreciation	0	5,523
Investments	3,227	2,490
Accrued compensation	2,525	1,527
Other accrued liabilities	905	418
Other	2,055	3,334
Total deferred tax assets	387,410	266,112
Deferred tax liabilities:
Operating lease right-of-use assets	(9,345)	(4,668)
Depreciation	(2,905)	0
Indefinite-lived intangible assets	(162)	(170)
Total deferred tax liabilities	(12,412)	(4,838)
Net deferred tax assets	374,998	261,274
Valuation allowance	(375,160)	(261,444)
Net deferred tax liability	$ (162)	$ (170)

Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax [Line Items]
Federal net operating losses	$ 1,300,000
State net operating losses	1,200,000
Foreign net operating losses	8,000
Valuation allowance, including rounding variance	375,100
Valuation allowance	375,160	$ 261,444
Increase (decrease) in valuation allowance	113,700	$ 63,400
Portion of valuation allowance credited directly to contributed capital	$ 200
Federal statutory tax rate	21.00%	21.00%	21.00%
Company's effective tax rate	0.00%	0.80%	0.10%
Deferred tax assets not recognized due to limitations	$ 274,200
Research and development credits	17,716	$ 21
Deferred tax assets, interest expense temporarily disallowed	33,100	$ 19,600
Unrecognized tax benefits that would not impact effective tax rate	11,400
Federal
Income Tax [Line Items]
Net operating losses not subject to expiration	850,300
Research and development credits	22,600
State
Income Tax [Line Items]
Net operating losses not subject to expiration	50,400
Research and development credits	$ 8,400

Income Taxes - Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate (Details)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Federal statutory tax rate	21.00%	21.00%	21.00%
State income taxes, net of federal tax benefit	7.00%	7.20%	(0.80%)
Other permanent items	(0.10%)	(0.10%)	1.60%
Tax rate adjustment	1.50%	(0.30%)	0.20%
Research and development credits	3.70%	0.10%	0.10%
Stock-based compensation	0.50%	1.30%	(33.90%)
Other	(0.90%)	(0.20%)	0.20%
Valuation allowance	(32.70%)	(28.20%)	11.70%
Effective income tax rate	0.00%	0.80%	0.10%

Income Taxes - Changes to Unrecognized Tax Benefits (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Unrecognized tax benefits, beginning of year	$ 20,413	$ 15,656	$ 11,983
Additions based on tax positions related to the current year	536	4,763	3,680
Reductions for tax positions of prior years	(7,445)	(6)	(7)
Unrecognized tax benefits, end of year	$ 13,504	$ 20,413	$ 15,656

Compensation Related Costs, General (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Compensation Related Costs [Abstract]
Discretionary contributions	$ 1.7	$ 1.1	$ 0.9

Subsequent Events (Details)	Feb. 14, 2022 USD ($) employee	Feb. 01, 2022 $ / shares shares	Jan. 07, 2022 ft²	Dec. 31, 2021 $ / shares shares	Mar. 09, 2021 $ / shares	Dec. 31, 2020 $ / shares shares
Subsequent Event [Line Items]
Common stock, shares authorized (in shares) \| shares				500,000,000		500,000,000
Common stock, par value (in dollars per share) \| $ / shares				$ 0.0001	$ 0.0001	$ 0.0001
Preferred stock, par value (in dollars per share) \| $ / shares				$ 0.0001
Preferred stock, shares authorized (in shares) \| shares				20,000,000
Subsequent Event
Subsequent Event [Line Items]
Common stock, shares authorized (in shares) \| shares		900,000,000
Common stock, par value (in dollars per share) \| $ / shares		$ 0.0001
Subsequent Event \| Dunkirk Facility
Subsequent Event [Line Items]
Number of square foot of facility leased \| ft²			409,000
Leasehold interest, price	$ 40,000,000
Annual lease payment	$ 2.00
Initial lease term	10 years
Lease renewal term	10 years
Commitment to spend, operational expenses, initial lease term	$ 1,520,000,000
Commitment to spend, operational expenses, renewal lease term	$ 1,500,000,000
Commitment to hire, number of employees, first five years \| employee	450
Commitment to hire, number of employees, first two and a half years \| employee	300

Label	Element	Value
Consolidation, Eliminations [Member]
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	$ 72,000
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(427,000)
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(794,000)
Revenues	us-gaap_Revenues	(44,000)
Revenues	us-gaap_Revenues	(1,201,000)
Revenues	us-gaap_Revenues	(835,000)
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	(106,000)
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	(739,000)
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	(41,000)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	72,000
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(427,000)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(565,000)
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	(10,000)
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	(35,000)
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	0
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	0
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	0
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	0
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	0
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	0
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	229,000
Impairment of Intangible Assets (Excluding Goodwill)	us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill	0
Nant Cell Inc [Member] \| Reportable Legal Entities [Member]
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(45,708,000)
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(128,827,000)
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(87,650,000)
Revenues	us-gaap_Revenues	183,000
Revenues	us-gaap_Revenues	1,695,000
Revenues	us-gaap_Revenues	2,994,000
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	21,509,000
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	75,763,000
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	62,253,000
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(46,556,000)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(131,377,000)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(93,804,000)
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	24,382,000
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	44,099,000
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	28,391,000
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	0
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	(1,851,000)
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	(8,000)
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	(848,000)
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	(4,401,000)
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	(6,162,000)
Impairment of Intangible Assets (Excluding Goodwill)	us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill	10,660,000
Nant Kwest Inc [Member] \| Reportable Legal Entities [Member]
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(40,628,000)
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(91,626,000)
Operating Income (Loss)	us-gaap_OperatingIncomeLoss	(67,807,000)
Revenues	us-gaap_Revenues	0
Revenues	us-gaap_Revenues	111,000
Revenues	us-gaap_Revenues	43,000
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	19,725,000
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	64,483,000
Research and Development Expense	us-gaap_ResearchAndDevelopmentExpense	49,785,000
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(33,997,000)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(92,383,000)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	us-gaap_ProfitLoss	(65,789,000)
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	20,903,000
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	27,254,000
Selling, General and Administrative Expense	us-gaap_SellingGeneralAndAdministrativeExpense	18,065,000
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	6,000
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	5,000
Income Tax Expense (Benefit)	us-gaap_IncomeTaxExpenseBenefit	(97,000)
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	6,637,000
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	(752,000)
Nonoperating Income (Expense)	us-gaap_NonoperatingIncomeExpense	1,921,000
Impairment of Intangible Assets (Excluding Goodwill)	us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill	$ 0

Fair Value Measurements - Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	$ 317,938	$ 97,011
Contingent consideration	(409)	(972)
Current Assets \| Equity securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	5,700	6,337
Current Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	115
Current Assets \| Mutual funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	38	37
Current Assets \| Cash and cash equivalents
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	181,101	34,915
Current Assets \| Corporate debt securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	129,164	54,772
Noncurrent Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	822	950
Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	59,094	42,239
Contingent consideration	(388)	0
Level 1 \| Current Assets \| Equity securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	6,698	6,337
Level 1 \| Current Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	115
Level 1 \| Current Assets \| Mutual funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	38	37
Level 1 \| Current Assets \| Cash and cash equivalents
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	51,421	34,915
Level 1 \| Current Assets \| Corporate debt securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 1 \| Noncurrent Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	822	950
Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	258,844	54,772
Contingent consideration	0	0
Level 2 \| Current Assets \| Equity securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 2 \| Current Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0
Level 2 \| Current Assets \| Mutual funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 2 \| Current Assets \| Cash and cash equivalents
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	129,680	0
Level 2 \| Current Assets \| Corporate debt securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	129,164	54,772
Level 2 \| Noncurrent Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Contingent consideration	(21)	(972)
Level 3 \| Current Assets \| Equity securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 3 \| Current Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0
Level 3 \| Current Assets \| Mutual funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 3 \| Current Assets \| Cash and cash equivalents
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 3 \| Current Assets \| Corporate debt securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	0	0
Level 3 \| Noncurrent Assets \| Foreign bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets measured at fair value	$ 0	$ 0